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        Evaluation of the Effects of Sildenafil Citrate (Viagra) on Vertebral Artery Blood Flow in Patients with Vertebro-Basilar Insufficiency

        Zulkif Bozgeyik,Sait Berilgen,Huseyin Ozdemir,Aslan Tekatas,Erkin Ogur 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.6

        Objective: To investigate the effects of sildenafil citrate (Viagra) on the vertebral artery blood flow of patients with vertebro-basilar insufficiency (VBI) using color duplex sonography (CDS). Materials and Methods: The study included 21 patients with VBI (aged 31-76; mean 61.0 ± 10.5 yrs). We administered a 50 mg oral dose of sildenafil citrate to all patients. Next, we measured the peak systolic velocity (Vmax), end diastolic velocity (Vmin), resistive index (RI), pulsatility index (PI), diameter, area, and flow volume (FV) of vertebral arteries using CDS before the administration of sildenafil citrate; 45 minutes after, and 75 minutes after administration. Statistical testing was performed using SPSS for windows version 11.0. The statistical test used to determine the outcome of the analysis was the repeated measures analysis of variance (ANOVA) test. Results: Compared to the baseline values, the vertebral artery diameter, area, and FV increased significantly following the administration of sildenafil citrate. The diameter, area and FV increased from 3.39 mm at 45 minutes to 3.64 mm at 75 minutes, 9.43 cm2 to 10.80 cm2 at 45 minutes and 10.81 cm2 at 75 minutes, as well as from 0.07 L/min at baseline to 0.09 L/min at 45 minutes and unchanged at 75 minutes, respectively. Conclusion: Sildenafil citrate elicited a significant effect on vertebral artery diameter, area and FVs. Objective: To investigate the effects of sildenafil citrate (Viagra) on the vertebral artery blood flow of patients with vertebro-basilar insufficiency (VBI) using color duplex sonography (CDS). Materials and Methods: The study included 21 patients with VBI (aged 31-76; mean 61.0 ± 10.5 yrs). We administered a 50 mg oral dose of sildenafil citrate to all patients. Next, we measured the peak systolic velocity (Vmax), end diastolic velocity (Vmin), resistive index (RI), pulsatility index (PI), diameter, area, and flow volume (FV) of vertebral arteries using CDS before the administration of sildenafil citrate; 45 minutes after, and 75 minutes after administration. Statistical testing was performed using SPSS for windows version 11.0. The statistical test used to determine the outcome of the analysis was the repeated measures analysis of variance (ANOVA) test. Results: Compared to the baseline values, the vertebral artery diameter, area, and FV increased significantly following the administration of sildenafil citrate. The diameter, area and FV increased from 3.39 mm at 45 minutes to 3.64 mm at 75 minutes, 9.43 cm2 to 10.80 cm2 at 45 minutes and 10.81 cm2 at 75 minutes, as well as from 0.07 L/min at baseline to 0.09 L/min at 45 minutes and unchanged at 75 minutes, respectively. Conclusion: Sildenafil citrate elicited a significant effect on vertebral artery diameter, area and FVs.

      • SCOPUSSCIEKCI등재

        추골-기저 동맥의 해리성 뇌동맥류의 진단과 치료

        김한성,박현선,주진양,김동익,이규창 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.6

        The authors have experienced seven cases of spontaneous intracranial dissecting aneurysm.Headache on the suboccipital region was the most common presenting symptom. Four patients had subarachnoid hemorrhage(SAH). Most of the patients were males : six men, one woman. The locations of the aneurysm were vertebral artery in six and basilar artery in one. An irregularly narrowed arterial segment with proximal and/or distal dilatation was the most significant angiogaphic findings. The introdution of MRI and DSA made the diagnosis of dissecting aneurysm easier in the suspicious cases with a traditional cerebral 4-vessel angiography. Five patients were treated surgicall : proximal clip occlusion of affected artery in three cases, trapping in one, wrapping combined with proximal clip occlution in another. The surgical results were excellent in all the cases. There was no further dissection of affected artery on postoperative follow-up angiography.

      • SCOPUSSCIEKCI등재

        A Morphological Study of Bony Bridges on Ko9rean Atlas

        Suh, Myung Suk,Hong, Soon Ki,Kim, Hun Ju,Han, Young Pyo,Sir, Won Seok,Chung, In Hyuk,Shin, Tai Sun 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4

        경추의 횡돌기공내를 주행하는 추골동맥이 두개강으로 들어가기전, 환추의 횡돌기공을 빠져나와 외측괴를 돌아 후궁의 추골동맥구를 지날 때 외측괴 주위로 골성교를 형성하는 수가 있다. 그 중에서 외측과와 후궁의 추골동맥구 사이에 뼈에의해 다리가 형성되는 경우가 후골성교(posterior bony bridege, ponticulus posticus), 외측괴와 횡돌기사이에 다리가 형성되는 경우를 측골성교(lateral bony bridge)라고 한다. 저자들은 이 골성교의 빈도와 그 형태학적 특징을 한국인의 골표본 및 엑스선 사진상에서 관찰하였다. 후궁과 외측괴사이에 형성되는 후골성교의 빈도를 보면 골표본의 경우 전체조사수 99예중 32예(32.2%)에서 완전 또는 불완전한 골성교를 보였으며, 남자의 경우 73예중 26예, 여자의 경우 26예중 6예에서 관찰할 수 있었다. 엑스선 소견상의 경우에는 300예중 113예(37.7)에서 골성교가 나타났었고, 이중 남자가 209예중 80예(37.7%), 여자가 91예중 33예(36.2%)를 보였었다. 횡돌기와 외측괴사이에 형성되는 측골성교의 빈도는 골표본에서만 조사하였던 바 전체조사수 99예중 20예(20.2%)가 완전 또는 불완전한 골성교를 보였으며, 이중 남자가 73예중 16예(21.9%), 여자가 26예중 4예(15.3%)였다.

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