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Kim, Sung Rae,Yoo, Ji Han,Song, Ho Cheol,Lee, Seong Su,Yoo, Soon Jib,Kim, Young-Du,Lim, Yeon Soo,Kim, Hyung Wook,Yang, Chul Woo,Kim, Yong-Soo,Choi, Euy Jin,Kim, Yong Kyun Springer International ; Oxford University Press 2011 Nephrology, dialysis, transplantation Vol.26 No.11
<P>Obesity and diabetes mellitus (DM) are established risk factors for the development of chronic kidney disease. Visceral adiposity (VAT) and subcutaneous adiposity (SAT) may be associated with the differential metabolic risk. Our study was performed to determine whether VAT or SAT was associated with the decrease of renal function in people with type 2 DM.</P>
The Oxford classification as a predictor of prognosis in patients with IgA nephropathy.
Kang, Seok Hui,Choi, Sun Ryoung,Park, Hoon Suk,Lee, Ja Young,Sun, In O,Hwang, Hyeon Seok,Chung, Byung Ha,Park, Cheol Whee,Yang, Chul Woo,Kim, Yong Soo,Choi, Yeong Jin,Choi, Bum Soon Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.1
<P>In 2009, the Oxford classification was developed as a pathological classification system for immunoglobulin A nephropathy (IgAN) to predict the risk of disease progression. The aim of this retrospective study was to evaluate the clinical and pathologic relevance of the Oxford classification in Korean patients with a pathologic diagnosis of IgAN.</P>
Cha, Ran-hui,Yang, Seung Hee,Kim, Hyo Sang,Kim, Sun Moon,Park, Myoung Hee,Ha, Jongwon,Kim, Yon Su Springer International ; Oxford University Press 2009 Nephrology, dialysis, transplantation Vol.24 No.9
<P>BACKGROUND: Acute rejection (AR) contributes to the development of chronic allograft nephropathy that is the major cause of graft failure. We analyzed the 59029G>A polymorphism and an internal 32 bp deletion (CCR5 32) of CCR chemokine receptor 5 (CCR5) Delta and tried to prove the hypothesis that genetic interactions between the donor and the recipient influence the development of AR. METHODS: We detected genetic polymorphisms by the TaqMan(R) method and by sizing PCR amplicons (n = 486). The primary outcomes were early acute rejection (EAR) and repeated early acute rejection (RR). We defined EAR as the occurrence of a biopsy-proven AR within 3 months after transplantation. RESULTS: The development of EAR was dependent on the number of A alleles in recipients and showed a dose-response relationship (P = 0.002). When we combined the number of A alleles in both donor and recipient, episodes of EAR and RR were more prevalent as the allelic number increased (A allelic number 0 & 1, 2 versus 3 & 4, P = 0.048; 0 & 1 versus 3 & 4, P = 0.006). Statistical significance was preserved after multivariate analysis of sex, HLA mismatch and type of donor with the recipient's age as the continuous term. Also, graft survival was different according to the presence of the A allele, i.e. recipients carrying A allele (+) grafts showed poor graft survival (P = 0.008 by a log-rank test). Again, the number of A alleles affected graft survival as the recipients who carried more A alleles had poor graft survival (A allele number 0 & 1 versus 2 versus 3 & 4, P = 0.011; 0 & 1 versus 3 & 4, P = 0.08; 0 & 1 versus 2, P = 0.002; by a log-rank test). All of the participants were wild-type homozygotes for CCR5Delta32. CONCLUSIONS: The A allele of CCR5 59029G>A was a risk factor for EAR and RR. As the number of A alleles increased, episodes of EAR were more frequently observed.</P>
O'Neill, Heidi,Lebeck, Janne,Collins, Patrick B,Kwon, Tae-Hwan,Frøkiaer, Jørgen,Nielsen, Søren Springer International ; Oxford University Press 2008 Nephrology, dialysis, transplantation Vol.23 No.5
<P>BACKGROUND: Diabetes mellitus (DM) is associated with a significant polyuria and natriuesis as well as increased plasma aldosterone and anti-diuretic hormone arginine vasopressin (AVP). This study aimed to determine whether diabetic kidneys compensate for the urinary sodium and water losses by increasing apical targeting of epithelial sodium channel (ENaC) subunits and aquaporin-2 (AQP2) in the collecting duct, in addition to the previously observed changes in ENaC subunit protein expression in different kidney zones. METHODS: Female rats were investigated 2 weeks after induction of DM by streptozotocin administration. Kidneys were examined by immunohistochemisty and semiquantitative immunoblotting. RESULTS: We demonstrated that the protein expression of renal AQP2, Ser-256 phosphorylated AQP2, AQP3, beta- and gamma-ENaC (but not alpha-ENaC) increased consistently with an increased AVP response. In contrast, there were no significant changes in the relative apical targeting of beta-, gamma- and alpha-ENaC, and the shift in the molecular weight of gamma-ENaC from 85 kDa to 70 kDa was not observed despite increased plasma aldosterone levels. These results were supported by changes in the functional data showing increased solute-free water reabsorption, increased fractional excretion of sodium and an unchanged ratio of potassium to sodium in the urine. CONCLUSIONS: The data demonstrate that diabetic kidneys have a reduced sensitivity to the anti-natriuretic action of elevated plasma aldosterone levels with no relative increase in ENaC subunit apical targeting, whereas there is increased expression of beta- and gamma-ENaC, which alone may play a role in the increased sodium reabsorption in the kidney in DM.</P>
Renoprotective antioxidant effect of alagebrium in experimental diabetes.
Park, Jehyun,Kwon, Min Kyung,Huh, Joo Young,Choi, Won Jun,Jeong, Lak Shin,Nagai, Ryoji,Kim, Wan Young,Kim, Jin,Lee, Geun Taek,Lee, Hi Bahl,Ha, Hunjoo Springer International ; Oxford University Press 2011 Nephrology, dialysis, transplantation Vol.26 No.11
<P>Despite the beneficial effects of alagebrium (ALA), a putative advanced glycation end-product (AGE) breaker, on diabetic nephropathy, its renoprotective mechanisms are incompletely understood. Since oxidative stress exacerbates diabetic renal injury through interaction with AGE, the present study examined the antioxidative property of ALA in db/db mice, mesangial cells cultured under high glucose or H(2)O(2) and a test tube.</P>
Apoptosis occurs differentially according to glomerular size in diabetic kidney disease.
Jung, Dong-Sub,Lee, Sun Ha,Kwak, Seung-Jae,Li, Jin Ji,Kim, Do Hee,Nam, Bo-Young,Kang, Hye Young,Chang, Tae Ik,Park, Jung Tak,Han, Seung Hyeok,Yoo, Tae-Hyun,Kang, Shin-Wook Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.1
<P>Apoptosis, which is involved in the process of mesangial cell and podocyte loss in diabetic nephropathy, is known to be regulated by protein kinase B/Akt (Akt). A number of studies have therefore investigated the activity of Akt under diabetic conditions, but the results have not been consistent. In this study, we hypothesized that apoptosis may occur differentially and that Akt may be differentially activated according to glomerular size in diabetic kidney disease.</P>
Oh, Yun Jung,Kim, Myounghee,Lee, Hajeong,Lee, Jung Pyo,Kim, Ho,Kim, Sejoong,Oh, Kook-Hwan,Joo, Kwon Wook,Lim, Chun Soo,Kim, Suhnggwon,Kim, Yon Su,Kim, Dong Ki Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.6
<P>Vitamin D deficiency is known as an important risk factor for mortality in patients with chronic kidney disease (CKD). Nevertheless, the association of renal function itself with vitamin D status or serum 25-hydroxyvitamin D (25OHD) level has not been investigated thoroughly.</P>
Jang, Hee-Seong,Kim, Jinu,Kim, Ki Young,Kim, Jee In,Cho, Min Hyun,Park, Kwon Moo Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.10
<P>Kidneys previously exposed to ischemia and reperfusion (I/R), pre-conditioned by I/R, are less susceptible to subsequent I/R injury. Here, we investigated the role for protein kinase B (Akt) survival signaling pathways including anti-apoptosis pathways in the reduced susceptibility of I/R-pre-conditioned kidneys.</P>
Park, Sun-Hee,Do, Jun-Young,Kim, Yeong Hoon,Lee, Ho Yung,Kim, Beom Seok,Shin, Sug-Kyun,Kim, Hyun Chul,Chang, Yoon-Kyung,Yang, Jong-Oh,Chung, Hyun-Chul,Kim, Chan-Duck,Lee, Won Kee,Kim, Jong-Yeon,Kim, Y Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.3
<P>The local peritoneal effects of low-glucose degradation product (GDP)-containing peritoneal dialysis fluid (PDF) have been extensively described. However, the systemic effects of prolonged prescription of these solutions are unknown. This study aimed to evaluate the effects of neutral pH and low-GDP PDF on systemic inflammation and endothelial dysfunction markers in peritoneal dialysis (PD) patients.</P>
Jung, Jae-Woo,Song, Woo-Jung,Kim, Yon-Su,Joo, Kwon Wook,Lee, Kyung Wha,Kim, Sae-Hoon,Park, Heung-Woo,Chang, Yoon-Seok,Cho, Sang-Heon,Min, Kyung-Up,Kang, Hye-Ryun Springer International ; Oxford University Press 2011 Nephrology, dialysis, transplantation Vol.26 No.11
<P>Although allopurinol is a very effective urate-lowering drug for complicated hyperuricemia, in some patients, it can induce severe cutaneous adverse reactions (SCARs). Recent investigations suggest that HLA-B*5801 is a very strong marker for allopurinol-induced SCARs, especially in the population with a high frequency of HLA-B*5801. Korea is one of the countries with a high frequency of HLA-B*5801 which is the only subtype of HLA-B58 in the Korean population. Objective. This study was conducted to find out the incidence of allopurinol-induced hypersensitivity on patients with chronic renal insufficiency (CRI) according to HLA-B58 and the clinical implications of HLA-B58 as a risk marker for the development of allopurinol-induced hypersensitivity.</P>