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AMC-HN3 두경부 암세포에서 Taxotere와 9-hydroxypheophorbide-a를 이용한 combination Photodynamic therapy의 세포독성능 연구
정필상,황희준,신장인,장소영,강정욱,권필승,이정구,안진철 대한광역학학회 2007 대한광역학학회지 = Journal of Korean Photodynamic Associat Vol.4 No.3
Photodynamic therapy (PDT) is now an established treatment for a number of neoplastic diseases. It involves a tumour localizing photosensitizer that induces cytotoxicity when activated by light of an appropriate wavelength. We report a series of experiments in vitro to define the viabilities of head and neck carcinoma cells (AMC-HN3) treating Taxotere and 9-HpbD-a (9-hydroxypheophorbide-a), a chlorophyll derivative, as a new photosensitizer. Cell viabilities of AMC-HN3 cells by the various concentrations of Taxotere are observed, they have a declined significance from 40.0 ug/ml of Taxotere and 0.29 ug/ml for 9-HpbD-a, respectively. The 9-HpbD-a mediated PDT and Taxotere combination therapy has an additive effect in some doses of experiments.
AMC-HN-4 두경부 암세포에서 Photofrin을 이용한 광역학 치료의 세포독성 연구
정필상,신장인,황희준,장소영,강정욱,권필승,이정구,안진철 대한광역학학회 2007 대한광역학학회지 = Journal of Korean Photodynamic Associat Vol.4 No.2
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. The molecular mechanisms involved in the development and progression of these carcinomas are not well known. The aim of this study was to investigate the mechanism of cell death by photodynamic therapy in head and neck cancer cell line. AMC-HN-4 cells were subjected to photodynamic therapy with photofrin (0.1-50 ug/ml) for different incubation time before photoirradiation. Photodynamic toxicity was investigated 24h after treatment. The type of cell death was determined using Hoechst 33342 stain methods. In this study, there was cytotoxicity of photofrin-induced photodynamic therapy in the AMC-HN-4 cells, and it was dose-dependent manner. Cell death by photofrin-induced photodynamic therapy was caused predominantly by apoptosis. Photodynamic therapy with photofrin significantly enhanced photocytotoxicity and apoptosis.