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- 저자 : Zhiqi Xie (검색결과 2 건)
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Zhiqi Huang,Xingyu Li,Tian Xie,Changjiang Gu,Kan Ni,Qingqing Yin,Xiaolei Cao,Chunhui Zhang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers—such as colorectal and gastric cancers. However, the expression of RIOK1 in breast cancer (BC) and the relationship between RIOK1 expression and the development of BC are not well characterized. In this study, we assessed the expression of RIOK1 in BC and evaluated the mechanisms underlying its biological function in this disease context. Materials and Methods We used immunohistochemistry, western blot and quantitative real-time polymerase chain reaction to evaluate the expression of RIOK1 in BC patients. Then, knockdown or overexpression of RIOK1 were used to evaluate the effect on BC cells in vitro and in vivo. Finally, we predicted miR-204-5p could be a potential regulator of RIOK1. Results We found that the expression levels of RIOK1 were significantly higher in hormone receptor (HR)–negative BC patients and was associated with tumor grades (p=0.010) and p53 expression (p=0.008) and survival duration (p=0.011). Kaplan-Meier analysis suggested a tendency for the poor prognosis. In vitro, knockdown of RIOK1 could inhibit proliferation, invasion, and induced apoptosis in HR-negative BC cells and inhibited tumorigenesis in vivo, while overexpression of RIOK1 promoted HR-positive tumor progression. MiR-204-5p could regulate RIOK1 expression and be involved in BC progression. Conclusion These findings indicate that RIOK1 expression could be a biomarker of HR-negative BC, and it may serve as an effective prognostic indicator and promote BC progression.
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Complete noncompact submanifolds of manifolds with negative curvature
Ya Gao,Yanling Gao,Jing Mao,Zhiqi Xie 대한수학회 2024 대한수학회지 Vol.61 No.1
In this paper, for an $m$-dimensional ($m\geq5$) complete noncompact submanifold $M$ immersed in an $n$-dimensional ($n\geq6$) simply connected Riemannian manifold $N$ with negative sectional curvature, under suitable constraints on the squared norm of the second fundamental form of $M$, the norm of its weighted mean curvature vector $|\textbf{\emph{H}}_{f}|$ and the weighted real-valued function $f$, we can obtain: \begin{itemize} \item several one-end theorems for $M$; \item two Liouville theorems for harmonic maps from $M$ to complete Riemannian manifolds with nonpositive sectional curvature. \end{itemize}
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