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Chenchen Wang,Junfeng Zhou,Yunkun Zhao,Youze Chen,Benli Yu,Liang Lu 한국물리학회 2019 Current Applied Physics Vol.19 No.4
This paper proposed a new method for measuring the feedback coefficient in the self-mixing interference. In experiment, the value of feedback coefficient is obtained by measuring the power difference at power jump point that based on the self-mixing vibration sensing system. It realized the measurement of feedback coefficient in range of 1–7.8 and shows a good agreement with the theoretical derivation and the corresponding simulation. Meanwhile, there is a good fitting result with the determination coefficient of 0.98 and line-width broadening factor of 3.245 respectively, which also realized measurement of feedback coefficient and line-width broadening factor at the same time.
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Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1
Wang Shanxi,Qu Yunkun,Fang Xuan,Ding Qing,Zhao Hongqi,Yu Xiaojun,Xu Tao,Lu Rui,Jing Shaoze,Liu Chaoxu,Wu Hua,Liu Yang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Ligamentum flavum hypertrophy (LFH) is the main physiological and pathological mechanism of lumbar spinal canal stenosis (LSCS). The specific mechanism for LFH has not been completely clarified. In this study, bioinformatic analysis, human ligamentum flavum (LF) tissues collection and analysis, and in vitro and in vivo experiments were conducted to explore the effect of decorin (DCN) on LFH pathogenesis. Here, we found that TGF-β1, collagen I, collagen III, α-SMA and fibronectin were significantly upregulated in hypertrophic LF samples. The DCN protein expression in hypertrophic LF samples was higher than that in non-LFH samples, but the difference was not significant. DCN inhibited the expression of TGF-β1-induced fibrosis-associated proteins in human LF cells, including collagen I, collagen III, α-SMA, and fibronectin. ELISAs showed that TGF-β1 can upregulate PINP and PIIINP in the cell supernatant, and this effect was inhibited after DCN administration. Mechanistic studies revealed that DCN suppressed TGF-β1-induced fibrosis by blocking the TGF-β1/SMAD3 signaling pathway. In addition, DCN ameliorated mechanical stress-induced LFH in vivo. In summary, our findings indicated that DCN ameliorated mechanical stress-induced LFH by antagonizing the TGF-β1/SMAD3 signaling pathway in vitro and in vivo. These findings imply that DCN is a potential therapeutic candidate for ligamentum flavum hypertrophy.
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