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( Yu Ri Kim ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Jae Wook Jung ),( Yu Na Lee ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: In the dermis, fibroblasts play a critical role in maintaining homeostasis. UV triggers apoptosis and growth arrest in fibroblasts. Therefore, UV radiation is one of the major inducers of disorders of the dermis. Troxerutin is a derivative of the natural bioflavonoid. As troxerutin has been shown to have radioprotective, anti-inflam¬matory and antioxidant effects, it seems likely that troxerutin may protect cells against UV-induced oxidative stress and DNA damage. Objectives: To investigate the mechanisms by which troxerutin protects cells against ultraviolet B (UVB) radiation. Methods: First, we demonstrate that pre-treatment with troxerutin protects normal human dermal fibroblasts (nHDFs) against UVB-induced cytotoxicity. Subsequently, we analyzed microRNA (miRNA) expression profiles in the nHDFs. Results: Troxerutin increased cell migra¬tion and DNA repair activity in the nHDFs. In UVB-exposed cells, miRNAs act on crucial functions, such as apoptosis and cellular senescence. miRNA expression is significantly altered during the protective process induced by phytochemicals. Conclusion: In this study, our findings indicate that pre-treatment with troxerutin increases the viability of UVB-exposed nHDFs through the alteration of the miRNA expression profiles.
( Yu Ri Kim ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Jae Wook Jung ),( Yu Na Lee ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options. Objectives: To evaluate a new-formula shampoo that contains natural ingredients, extract of Rosa centifolia petals and epigallocatechin gallate (EGCG), that exert antioxidative, anti-inflammatory and sebum secretion inhibitory effects, and antifungal agents for the treatment of scalp seborrheic dermatitis. Methods: Seventy-five patients were randomized into three groups: new-formula shampoo, 2% ketoconazole shampoo and 1% zinc-pyrithione shampoo. Clinical severity scores, sebum levels, user satisfaction and irritation were assessed at week 0, week 2 and week 4 after.Results: The efficacy of the new-formula shampoo was comparable to that of both the 1% zinc-pyrithione shampoo and the 2% ketoconazole shampoo. Furthermore, it was found to provide a more rapid response than the 1% zinc-pyrithione shampoo for mild erythema lesions and was associated with greater user satisfaction compared to the 2% ketoconazole shampoo. However, the new-formula shampoo did not exhibit the previously reported sebum inhibitory effect. Conclusion: Extract of Rosa centifolia petals or EGCG could be useful ingredients in treatments for scalp seborrheic dermatitis.
Thoracic Extradural Cavernous Hemangioma Mimicking a Dumbbell-Shaped Tumor
Jeong, Won Joo,Choi, Il,Seong, Han Yu,Roh, Sung Woo The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.46 No.4
Dumbbell-shaped spinal extradural cavernous hemangioma is rare. The differential diagnosis of dumbbell-shaped spinal tumors based on magnetic resonance imaging includes schwannoma and lymphoma. Here, we report a dumbbell-shaped spinal extradural cavernous hemangioma with intrathoracic growth on T2-3 in a 64-year-old man complaining of right side infrascapular area back pain with no neurologic deficit. The cavernous hemangioma was resected through combined video-assisted thoracoscopy and laminectomy without a fusion procedure. The patient had tolerable operative wound pain with no neurologic deficit after surgery. Based on magnetic resonance imaging findings and a review of the literature, we discuss cavernous hemangioma among the differential diagnosis of paravertebral dumbbell-shaped spinal tumors and the importance of complete resection.
P135 : Analysis of the safety and efficacy of three natural extracts in cosmetics
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The function of sebum in human is reducing water loss from the skin``s surface and protecting the skin from infection by microorganism. However, when there is excessive secretion of sebum, it will cause black heads and expansion of the pores so that waste will be accumulated. Objectives: To develop cosmetics for sebum removal and pore improvement that can improve limitations of the existing products. The ingredients include Diospyros kaki (D. kaki ), Castanea crenata (C. crenata), and Polygonum cuspidatum (P. cuspidatum) and to verify the safety and human efficacy evaluation. Methods: Bacteria microbial limit test and patch test performed with 31 participants. Also, with 23 participants who have oily skin, efficacy evaluation was performed. Changes in the amount of sebum, moisture, dead skin condition, blackhead, skin roughness between before and after the test were compared for control group. Results: As a result of safety assessment, there was no pathogenic microorganism for microbial limit test and, there was no skin reactions for patch test. For changes in the amount of sebum and black head from efficacy evaluation,there was temporary improvement for the experimental group. For the amount of moisture, dead skin, and skin roughness of the experimental group showed improvement. Conclusion: When being complemented with body application test for long-term usage, they can be used as natural ingredients when cosmetic manufacturers or sellers are developing new products.
P279 : The effects of freeze dried extract of dangyuja (citrus grandis osbeck) on melanogenesis
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Although previous studies have identified that both the fruit and leaf of dangyuja (Citrus grandis Osbeck) exhibits anticancer, antioxdant and anti-inflammatory effect, the inhibitory effect of melanogenesis have not been reported. Objectives: In this study, freeze dried extract of dangyuja was evaluated for their potential to inhibit melanogenesis. Methods: Cytotoxicity and melanin content in mouse B16F10 melanoma cells were assayed after treatment with the freeze dried extracts of dangyuja. Results: Freeze dried extracts of dangyuja strongly decreased the tyrosinase activity for catalysis of L-dihydroxyphenylalanine (L-DOPA) oxidation in a dose- dependent manner. The results demonstrate that extracts possessed low cytotoxic activity and that melanin content was reduced. Conclusion: Freeze dried extracts of dangyuja is a safe natural materials that show an effective inhibition of melanogenesis. These results suggest that freeze dried extracts of dangyuja can be considered as an effective skin whitening reagent for application in cosmetics.