http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ya-Qin Gao,Zhi-Xin Zhang,Ye-Yin Zhao,Fu-Hu Liu 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.7
Isotopic cross-sections of projectile-like residues produced in 112Sn + 112Sn and 124Sn + 124Sn reactions at an incident beam energy of 1A GeV are studied in the framework of the multi-source thermal model. The multiplicity-like distribution of neutrons in projectile-like isotopes can be successfully expressed by using the Erlang distribution which is the folding result of multi-exponential distributions with the same parameter. The results calculated by using the model are in agreement with the experimental data of Föhr et al. [arXiv:1106.5368vl [nucl-ex]].
High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis
Gao Ya-chen,Jiang Nan-nan,Qin Xiu-juan,Jiang Hui,Wei Liang-bing,Gao Jia-rong 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Circular RNAs (circRNAs), a unique novel type of RNA, have been widely reported to be involved in physiologic and pathologic processes in humans. However, the exact molecular pathogenesis of circRNAs in chronic glomerulonephritis (CGN) is far from clear. Objective This paper aims to evaluate the specific expression profile of circRNAs in renal cortex tissues from Adriamycin-induced CGN rats. Methods CircRNAs were screened in renal cortex tissues from 3 CGN rats and 3 control rats by using high-throughput sequencing (HTS). Then, 4 circRNAs were selected randomly for verification by quantitative real-time polymerase chain reaction (qRT-PCR). In addition, the differentially expressed (DE) circRNAs were analyzed by bioinformatics methods. Results In total, 31 significantly DE circRNAs were identified, which revealed their potential roles in CGN; in particular, we found that 4 confirmed altered circRNAs (rno-circ-RNAs 689, 3217, 1327, and 5001) might play important roles in the development of CGN. Conclusion This study reveals a cluster of circRNAs that are DE in Adriamycin-induced CGN rats, which brings us closer to understanding the pathogenic mechanisms and may provide new potential targets for clinical treatment.
Lin Xiong,Ya-Qin Gao,Wei-Hong Li,Tian-Feng Guo,Xiao-Lin Yang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.5
An LC-MS/MS method was established for simultaneous identification of levels of bilpaterol, cimbuterol, clenproperol, and bambuterol in goat and beef muscle. Meat samples were subjected to extraction using an aqueous acidic solution and cleansed using MCX solid phase extraction. β2-Agonists residues were extracted using an aqueous acidic solution. Proteins in extraction liquids was removed based on adjusting pH using perchloric acid and a sodium hydroxide solution, followed by SPE for clean-up. Linearity values of the method based on R2 values were 0.9976-0.9997 with 70.1-108.8% recovery and relative standard deviation values of 3.5-13.3%. Low limits of detection (LOD) and quantitation (LOQ) of 0.01-0.02 and 0.02-0.08 μg/kg, respectively, were achieved for spiked goat and spiked beef muscle. The method was sensitive and specific and is an improvement over other currently available technologies.
Li, Fu-Rong,Jiao, Peng,Yao, Shu-Tong,Sang, Hui,Qin, Shu-Cun,Zhang, Wei,Zhang, Ya-Bin,Gao, Lin-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Background: The inhibition of tumor cell growth without toxicity to normal cells is an important target in cancer therapy. One possible way to increase the efficacy of anticancer drugs and to decrease toxicity or side effects is to develop traditional natural products, especially from medicinal plants. Paris polyphylla Smith has shown anti-tumour effects by inhibition of tumor promotion and inducement of tumor cell apoptosis, but mechanisms are still not well understood. The present study was to explore the effect of Paris polyphylla Smith extract (PPSE) on connexin26 and growth control in human esophageal cancer ECA109 cells. Methods: The effects of PPSE on Connexin26 were examined by RT-PCR, western blot and immunofluorescence; cell growth and proliferation were examined by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Results: PPSE inhibited the growth and proliferation on esophageal cancer ECA109 cells, while increasing the expression of connexin26 mRNA and protein; conversely, PPSE decreased Bcl-2 and increased Bad. Conclusion: This study firstly shows that PPSE can increase connexin26 expression at mRNA and protein level, exerting anti-tumour effects on esophageal cacner ECA109 cells via inhibiting cell proliferation and inducing cell apoptosis.