Characteristics and Risk Factors of Functional Dyspepsia Fulfilling the Rome IV Criteria Overlapping With Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China

( Yan-qin Long ),( Wen-li Xu ),( Lu-xiu Li ),( Hui-qin He ),( Jing-jie Wang ),( Guo-dong Shan ),( Ning Dai ),( Hong-tan Chen ) 대한소화기기능성질환·운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.2

Background/Aims Functional dyspepsia (FD) overlapping with other gastrointestinal disorders are quite common. The characteristics of FD overlap in Chinese population with latest Rome IV criteria were unclear. This large-scale outpatient-based study assessed the characteristics of FD overlap in South China. Methods Consecutive FD patients visited the Gastroenterology Clinic at 2 tertiary medical centers in Hangzhou, China who fulfilled the Rome IV criteria were enrolled. Complete questionnaires related to the gastrointestinal symptoms (Rome IV criteria), Reflux Disease Questionnaire, anxiety and depression, quality of sleep and life, and demographic information were collected. Results Among the total of 3281 FD patients, 50.69% overlapped with gastroesophageal reflux disease, 21.46% overlapped with irritable bowel syndrome, 6.03% overlapped with functional constipation. FD overlap had higher proportion of single/divorced/widowed rate, high education level, being employed, drinking, night shift, unhealthy dietary habit than FD only (P < 0.05). They had higher frequency of consultation and economic burden, as well as lower scores in quality of life (P < 0.001). Multivariate logistic regression showed that increasing age, female, low body mass index, history of gastroenteritis, anxiety, depression, and poor sleep quality were independent risk factors for FD overlap. Conclusions FD overlap was quite common in China with high economic burden and poor quality of life, FD patients with history of gastroenteritis, anxiety, depression, and poor sleep quality were more likely to have overlap disorders. Awareness of the physical and psychosocial stressors in overlapping condition would help optimize the management of FD overlap in clinical practice. (J Neurogastroenterol Motil 2024;30:184-193)

IL-11 promotes the treatment efficacy of hematopoietic stem cell transplant therapy in aplastic anemia model mice through a NF-κB/microRNA-204/thrombopoietin regulatory axis

Yan Wang,Zhi-yun Niu,Yu-jie Guo,Li-hua Wang,Feng-ru Lin,Jing-yu Zhang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Hematopoietic stem cell (HSC) transplantation could be of therapeutic value for aplastic anemia (AA) patients, and immunosuppressants may facilitate the efficiency of the procedure. As anti-inflammatory cytokine interleukin-11 (IL-11) has a thrombopoietic effect, its use in cases of chronic bone marrow failure, such as AA, has been proposed to induce HSC function. However, the putative mechanisms that may support this process remain poorly defined. We found that decreased miR-204-5p levels were coincident with increased proliferation in mouse HSCs following exposure to IL-11 in vitro. Through inhibiting NF-кB activity, miR-204-5p repression was demonstrated to be a downstream effect of IL-11 signaling. miR-204-5p was shown to directly target thrombopoietin (TPO) via sequence-dependent 3′-UTR repression, indicating that this microRNA-dependent pathway could serve an essential role in supporting IL-11 functions in HSCs. Increased TPO expression in HSCs following IL-11 exposure could be mimicked or blocked by inhibiting or overexpressing miR-204-5p, respectively. Consistent with these in vitro findings, IL-11 promoted HSC engraftment in a mouse model of AA, an effect that was attenuated in cells overexpressing miR-204-5p. The reduction in miR-204-5p levels is an integral component of IL-11 signaling that may play an essential role in treating AA.

Effect of Li on the microstructure and electrical properties of (K_0.17Na_0.83)NbO_3 lead-free piezoceramics

Guo-Zhong Zang,Yan Wang,Xiu-Jie Yi,Juan Du,Zhi-Jun Xu 한국물리학회 2011 Current Applied Physics Vol.11 No.2

Lead-free (K_0.17Na_(0.83-x)Li_x)NbO_3 piezoceramics were synthesized by conventional solid state sintering and the effect of Li on the microstructure and electrical properties was investigated. The experimental results show that 4 mol% Li doping facilitates the grain growth and increases the density of the ceramics. The measurement of dielectric properties reveals that the orthorhombic-tetragonal (T_(O-T)) and tetragonalcubic (T_C) phase transition temperatures change linearly with increasing Li content and the sample with x = 0.06 exhibits the highest T_C of 429 ℃ and lowest T_(O-T) of 181 ℃. Because of the wide apart of T_(O-T) from room temperature, no polymorphic phase structures were obtained and the piezoelectric strain coeffi-cient d_33 and piezoelectric coupling constant k_p varied between low values of 57, 61 pC/N and 0.18, 0.24,respectively with less than 6 mol% Li doping.

The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies

Yanli Guo,Ke You,Li Geng,Jie Qiao 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.4

Objective: This study was performed to evaluate the clinical performance of APTIMA human papillomavirus (AHPV) assay and Hybrid Capture 2 (HC2) assay in screening for cervical disease, especially in women with atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL). Methods: A total of 411 women diagnosed with ASC-US or LSIL were referred and further triaged by HC2 test. Prior to colposcopy, liquid-based cytology specimens were collected for the AHPV assay. Sensitivity and specificity were established based on the histological findings of cervical intraepithelial neoplasia (CIN). Results: In all 411 subjects, the positive detection rate of AHPV assay was 70.8% (95% confidence interval [CI], 66.4 to 75.2), which was significantly lower than the positive detection rate of 94.9% obtained using HC2 test (95% CI, 92.3 to 96.8). Only one CIN 3-positive case was detected among the 120 AHPV-negative women, which was then confirmed by Pap smear test to be LSIL. The sensitivities of AHPV and HC2 for CIN 3 were similar (94.1% and 100%, respectively). However, AHPV showed a significantly higher specificity than HC2 test (30.2% and 5.3%, respectively; p<0.001). Conclusion: AHPV assay is effective in identifying CIN 3-positive cases because of its high specificity and lower false-negative rate. The use of AHPV for the triage of ASC-US and LSIL might help to reduce the referral rate of colposcopy during cervical cancer screening.

Research on the Solution and Properties of Ni-P/n-A1203 Electroless Composite Plating

( Yan Bin Huang ),( Fei Fei Liu ),( Qi Yong Zhang ),( Guo Zhao Ba ),( Zhi Jie Liang ) 한국부식방식학회(구 한국부식학회) 2007 Corrosion Science and Technology Vol.6 No.5

Comparative Proteomic Analysis of Yak Follicular Fluid during Estrus

Guo, Xian,Pei, Jie,Ding, Xuezhi,Chu, Min,Bao, Pengjia,Wu, Xiaoyun,Liang, Chunnian,Yan, Ping Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.9

The breeding of yaks is highly seasonal, there are many crucial proteins involved in the reproduction control program, especially in follicular development. In order to isolate differential proteins between mature and immature follicular fluid (FF) of yak, the FF from yak follicles with different sizes were sampled respectively, and two-dimensional gel electrophoresis (2-DE) of the proteins was carried out. After silver staining, the Image Master 2D platinum software was used for protein analysis and matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) was performed for differential protein identification. The expression level of transferrin and enolase superfamily member 1 (ENOSF1) was determined by Western blotting for verification analysis. The results showed that 2-DE obtained an electrophoresis map of proteins from mature and immature yak FF with high resolution and repeatability. A comparison of protein profiles identified 12 differently expressed proteins, out of which 10 of them were upregulated while 2 were downregulated. Western blotting showed that the expression of transferrin and ENOSF1 was enhanced with follicular development. Both the obtained protein profiles and the differently expressed proteins identified in this study provided experimental data related to follicular development during yak breeding seasons. This study also laid the foundation for understanding the microenvironment during oocyte development.

Crack‑free TiO2 films prepared by adjusting processing parameters via liquid phase deposition technique

Jie Li,Hai‑Yan Xu,Ai‑Guo Wang,Feng‑Jun Zhang,Dao‑Sheng Sun,Won‑Chun Oh 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.2

TiO2 thin films with controllable morphology and grain size were prepared via a liquid phase deposition (LPD) technique. The effects of the processing parameters including the ( NH4)2TiF6 concentration, solution pH, and ( NH4)2TiF6:H3BO3 molar ratio on the grain size and morphology of the films were investigated. The prepared samples were characterized by X-ray diffraction, scanning electron microscopy, and ultraviolet–visible spectroscopy. The results showed that the deposition parameters significantly affected the growth and nucleation velocities of the crystalline grains, which resulted in the formation of TiO2 films with different morphologies and grain sizes. The capillary stress among the grains of the film, which resulted in the cracking of the film, depended on the size of the grains. Thus, the cracking of the LPD-derived TiO2 films could be mitigated by adjusting the deposition parameters.

Acaricidal activity of Aloe vera L. leaf extracts against Tetranychus cinnabarinus (Boisduval) (Acarina: Tetranychidae)

Jie Wei,Wei Ding,Yan-Guo Zhao,Patcharaporn Vanichpakorn 한국응용곤충학회 2011 Journal of Asia-Pacific Entomology Vol.14 No.3

Four different extracts of Aloe vera L. leaves were evaluated for acaricidal activity against female adults of carmine spider mite, Tetranychus cinnabarinus (Boisduval), by slide-dip bioassay. At 72 h after treatment, the acetone extract showed the strongest acaricidal activity with LC_50 value of 90 ppm. The LC_50 values for ethyl acetate, water, and ethanol extracts were 113, 340, and 391 ppm, respectively. The acetone extract was fractionated using a silica gel column. Among the twenty-two fractions obtained the fifth, tenth, eleventh,twelfth, fifteenth, and seventeenth fractions showed strong acaricidal activity, causing 80.39 to 92.16%mortality at 72 h after treatment. The tenth and eleventh fractions had the strong activity, with LC_50 values of 44 ppm and 33 ppm, respectively. The results suggested that A. vera has a great potential for development as a botanical acaricide for T. cinnabarinus control.

A Nationwide Survey of Privatized Firms in China

Yan Guo,Jie Gan,Chenggang Xu 서울대학교 경제연구소 2008 Seoul journal of economics Vol.21 No.2

This descriptive study is based on a nationwide survey of privatization in China. Between 1995 and 2005, close to 100,000 firms with 11.4 trillion RMB in assets were privatized in China. This privatization process encompassed two-thirds of state-owned enterprises and state assets. Privatization in China has created concentrated private ownership and greatly changed corporate governance. After privatization, the state has withdrawn from firms' daily decision making. Soft budget constraints have been substantially hardened. Firms have become more efficient and more profitable.

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Jing, Jie-Xian,Wang, Yan,Xu, Xiao-Qin,Sun, Ting,Tian, Bao-Guo,Du, Li-Li,Zhao, Xian-Wen,Han, Cun-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

To evaluate the value of combined detection of serum CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS for the clinical diagnosis of upper gastrointestinal tract (GIT) cancer and to analyze the efficacy of these tumor markers (TMs) in evaluating curative effects and prognosis. A total of 573 patients with upper GIT cancer between January 2004 and December 2007 were enrolled in this study. Serum levels of CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS were examined preoperatively and every 3 months postoperatively by ELISA. The sensitivity of CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS were 26.8%, 36.2%, 42.9%, 2.84%, 25.4%, 34.6%, 34.2% and 30.9%, respectively. The combined detection of CEA+CA199+CA242+CA724 had higher sensitivity and specificity in gastric cancer (GC) and cardiac cancer, while CEA+CA199+CA242+SCC was the best combination of diagnosis for esophageal cancer (EC). Elevation of preoperative CEA, CA19-9 and CA24-2, SCC and CA72-4 was significantly associated with pathological types (p<0.05) and TNM staging (p<0.05). Correlation analysis showed that CA24-2 was significantly correlated with CA19-9 (r=0.810, p<0.001). The levels of CEA, CA19-9, CA24-2, CA72-4 and SCC decreased obviously 3 months after operations. When metastasis and recurrence occurred, the levels of TMs significantly increased. On multivariate analysis, high preoperative CA72-4, CA24-2 and SCC served as prognostic factors for cardiac carcinoma, GC and EC, respectively. combined detection of CEA+CA199+CA242+SCC proved to be the most economic and practical strategy in diagnosis of EC; CEA+CA199+CA242+CA724 proved to be a better evaluation indicator for cardiac cancer and GC. CEA and CA19-9, CA24-2, CA72-4 and SCC, examined postoperatively during follow-up, were useful to find early tumor recurrence and metastasis, and evaluate prognosis. AFP, TPA and TPS have no significant value in diagnosis of patients with upper GIT cancer.