다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

자궁근종에서 Phospholipase C 동종효소들의 발현에 관한 연구

윤혜원,류임주,김창미,심재철,서영석 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.4

근접센서를 이용한 자동 두께 측정 시스템

주해호,박현제,정길도,이재원 嶺南大學校 工業技術硏究所 1994 工業技術硏究所論文集 Vol.22 No.2

This paper describes the automatic thickness measurement of the surface grinder for a grinding wheel by application of a proximity sensor, a limit switch, and PLC. The control system is designed to provide feeding a workpiece on the turn-table and pressing it by the upper disk automatically. In the process, the automation of checking the thickness of a grinding wheel is most important. In order to measure the relative displacement, the proximity sensors were employed and the sensitivities of the sensors were investicated and discussed the superiority. It has been shown by model experiment that the automation system of the surface grinder is performed satisfactory.

1997學年度 新入生 實態調査

元俊載,朴州信,鄭永壽 인하대학교 학생생활연구소 1998 學生生活硏究 Vol.18 No.-

순천향의대에서 문제중심학습의 실행 및 평가

김주자,이경재,원종호,이동환,안의태 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objects : Problem based learning (PBL) was practiced the 2nd grade students of Soonchunhyand medical school for two weeks from Dec. 10th through 24th, 2001. This is to evaluate the effect of the PBL practice Materials and Methods : On study module was discussed each week for 17 small groups. Each group had 6-7 students and 1 tutor. Questionnaire was applied to both students and 20 tutors. The questions were grouped in 6 categories, that is, understanding and satisfaction about the PBL, the process of small group discussion and group activity in self-learning method, PBL module and tools for study, opinion about tutors evaluation method etc. And advantages, disadvantages and other opinions were described in self-administration. Results : Both students and tutors had satisfied the PBL practice positively. Practices of "self-learning and active discussion instead of spoon-feeding methods", "problem-solving ability and medical reasoning" were described as advantages, "inefficiency and loss of time because of poor process during the discussion", "time consuming and much loading problems in self-learning practice because lack of training" "time consuming and mush loading problems in self-learning practice because lack of training" "lack of study room" were described as disadvantages.

유한요소법에 의한 콘크리트의 파괴진행해석

송하원,변근주,양재성 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2

Fracture machines does work for concrete, provided that one uses a proper, nonlinear form of fracture mechanics in which a finite nonlinear zone at fracture front is being considered. The fracture process zone is a region ahead of a traction-free crack, in which two major mechanisms, microcraking and bridging, play important rules. The development of model of fracture process zone is most important to describe fracture phenomena in concrete. The toughness due to bridging is dominant compared to the toughness induced by the microcracking, so that the bridging is the dominant mechanism governing the fracture process of concrete. In this paper the bridging zone, which is a part of extended macrocrack with stresses transmitted by aggregates in concrete, is modelled by a Dugdale-Barenblatt type model with linear tension-softening curve. Finite element techniques are shown for implementation of the model for the analyses of crack growth in concrete.

特定有害産業廢棄物의 適正管理에 關한 硏究

梁在崙,金元滿,朴在柱 한국환경독성학회 1991 환경독성보건학회지 Vol.6 No.1

The specified industrial wastes increased 26% annually during the last 5 years from 1984 to 1988 in Korea, and the special treatment and proper management are required. The effective methods are studied on the process of generation, keeping, transportation, and treatment/disposal for specified industrial wastes and materials. Also, in this paper, the author describes the plans to develop the public disposal facilities and manage specific industrial waste properly in Korea.

크리깅 기법을 이용한 마이크로 믹서의 최적 설계

박재용,김상락,이원구,유진식,김용대,한석영,맹주성 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

An active micro-mixer, which was composed of an oscillating micro-stirrer in the microchannel to provide rapid, effective mixing at high flow rates was analyzed. The effects of molecular diffusion and disturbance by the stirrer were considered with regard to two types of mixer models: the simple straight microchannel and microchannel with an oscillating stirrer. Two types of mixer models were studied by analyzing mixing behaviors such as their interactionafter the stirrer. The mixing was calculated by Lattice Boltzmann methods using the D2Q9 model. In this study, the time-averaged mixing index formula was used to estimate the mixing performance of time-dependent flow. The mixing indices of the two models were compared. From the results, it was found that the mixer with an oscillating stirrer was much more enhanced and stabilized. Therefore, an optimum design for a dynamic micro-mixer with an oscillating stirrer was performed using Kriging method in order to obtain a optimum solution. The design parameters were established as the frequency, the length and the angle of the stirrer, and the optimal values were determined to be 2.0932, 0.8D and ± 75°, respectively. It was found that the mixing index of the optimal design increased by 88.47% compared with that of the original design.

건조효과를 고려한 준설매립토의 압밀거동

유남재,박병수,이명욱,이주원 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

This research is to investigate the self-weight consolidation settlement and desiccation shrinkage settlement of soft marine dredging clay by performing numerical and experimental works. Large column test were carried out investigate the consolidation settlement considering effect of the self-weight and desiccation shrinkage, and centrifuge model test was also carried out investigate self-weight consolidation settlement. Results of centrifuge model and large column experiments about changes of settlement with time were analyzed by using the numerical technique of explicit finite difference method considering effect of the self-weight and desiccation based on the finite strain consolidation theory. Centrifuge model test results were in relatively good agreements with analyzed results in terms of self-weight consolidation settlement with time. Large column test results showed quite different values from the numerically estimated one, carried by experimental conditions.

정보통신 서비스의 실패 요인 : 한국의 텔레콤 서비스시장에서의 실패사례연구

안재현,권재원,김명수,이동주,이상윤,한상필 한국경영과학회 2002 한국경영과학회지 Vol.27 No.3

In this paper, 15 South Korean telecommunications service failure cases were analyzed. Through the in-depth case study, 8 factors were found to be the major causes contributing to the telecommunications service failure. They were (1) ineffective marketing, (2) poor demand forecasting due to misjudgment of customer preference, (3) failure to satisfy technical specifications, (4) loss of cost advantage due to the price cut of competing service or new entry with power price, (5) loss of utility advantage due to the increased utility of competing service or new entry with higher utility (6) decrease of market attractiveness due to change of customer preference, (7) impact of government policy, and (8) insufficient or low quality of contents. Additional analysis was done to derive managerial implications to the new telecommunications service development strategy. The findings from the paper will provide valuable insight to the successful implementation of new service development and service provisioning processes.