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Wen-Hao Zhang,Seung-Jae Lee,Myeon-Song Choi 대한전기학회 2010 Journal of Electrical Engineering & Technology Vol.5 No.3
This paper proposes a probability measure for the evaluation of relay performance from two aspects, namely, correct trip and no-unwanted trip. They are developed based on the relationship between relay settings and relay measurements, which follow a Gaussian probability model. The proposed method based on strict mathematical derivation is applied to protection capability evaluation of distance relays under various settings. Considering the specific attributes of each protection zone, the optimal settings are also determined accordingly. The protection capability could demonstrate clearly the relay performance under various settings and the optimal settings could provide good references for engineering applications.
Wen, Chun-Jie,Wu, Lan-Xiang,Fu, Li-Juan,Shen, Dong-Ya,Zhang, Xue,Zhang, Yi-Wen,Yu, Jing,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Estrogens are considered the major breast cancer risk factor, and the carcinogenic potential of estrogens might be attributed to DNA modification caused by derivatives formed during metabolism. $17{\beta}$-estradiol ($E_2$), the main steroidal estrogen present in women, is metabolized via two major pathways: formation of 2-hydroxyestradiol (2-OH $E_2$) and 4-hydroxyestradiol ($4-OH\;E_2$) through the action of cytochrome P450 (CYP) 1A1 and 1B1, respectively. Previous reports suggested that $2-OH\;E_2$ has putative protective effects, while $4-OH\;E_2$ is genotoxic and has potent carcinogenic activity. Thus, the ratio of $2-OH\;E_2/4-OH\;E_2$ is a critical determinant of the toxicity of $E_2$ in mammary cells. In the present study, we investigated the effects of berberine on the expression profile of the estrogen metabolizing enzymes CYP1A1 and CYP1B1 in breast cancer MCF-7 cells. Berberine treatment produced significant induction of both forms at the level of mRNA expression, but with increased doses produced 16~ to 52~fold greater induction of CYP1A1 mRNA over CYP1B1 mRNA. Furthermore, berberine dramatically increased CYP1A1 protein levels but did not influence CYP1B1 protein levels in MCF-7 cells. In conclusion, we present the first report to show that berberine may provide protection against breast cancer by altering the ratio of CYP1A1/CYP1B1, could redirect $E_2$ metabolism in a more protective pathway in breast cancer MCF-7 cells.
Genomic Screening for Targets Regulated by Berberine in Breast Cancer Cells
Wen, Chun-Jie,Wu, Lan-Xiang,Fu, Li-Juan,Yu, Jing,Zhang, Yi-Wen,Zhang, Xue,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Berberine, a common isoquinoline alkaloid, has been shown to possess anti-cancer activities. However, the underlying molecular mechanisms are still not completely understood. In the current study, we investigated the effects of berberine on cell growth, colony formation, cell cycle distribution, and whether it improved the anticancer efficiency of cisplatin and doxorubicin in human breast cancer estrogen receptor positive (ER+) MCF-7 cells and estrogen receptor negative (ER-) MDA-MB-231 cells. Notably, berberine treatment significantly inhibited cell growth and colony formation in the two cell lines, berberine in combination with cisplatin exerting synergistic growth inhibitory effects. Accompanied by decreased growth, berberine induced G1 phase arrest in MCF-7 but not MDA-MB-231 cells. To provide a more detailed understanding of the mechanisms of action of berberine, we performed genome-wide expression profiling of berberine-treated cells using cDNA microarrays. This revealed that there were 3,397 and 2,706 genes regulated by berberine in MCF-7 and MDA-MB-231 cells, respectively. Fene oncology (GO) analysis identified that many of the target genes were involved in regulation of the cell cycle, cell migration, apoptosis, and drug responses. To confirm the microarray data, qPCR analysis was conducted for 10 selected genes based on previously reported associations with breast cancer and GO analysis. In conclusion, berberine exhibits inhibitory effects on breast cancer cells proliferation, which is likely mediated by alteration of gene expression profiles.
A Probabilistic Method Based Protectability Evaluation of Distance Relay in Transmission Networks
Wen-Hao Zhang,Myeon-Song Choi,Seung-Jae Lee,Il-Hyung Lim,Seong-Jeong Rim 대한전기학회 2008 Journal of Electrical Engineering & Technology Vol.3 No.3
This paper defines the concept of "protectability" for the performance evaluation of distance relay considering its sensitivity and selectivity. The paper starts from the probabilistic modeling of the errors, and based on this model, a detailed explanation of protectability calculation for each zone of the distance relay is presented. An effect of the Weighting Rate and the Measurement Deviation on the protectability evaluation is also given. By considering this effect, the optimization of relay setting can be realized. The proposed method is applied to a typical model system to show its effectiveness
Zhang, Wen-Hao,Rosadi, Umar,Choi, Myeon-Song,Lee, Seung-Jae,Lim, Il-Hyung The Korean Institute of Electrical Engineers 2011 Journal of Electrical Engineering & Technology Vol.6 No.1
This paper proposes an enhanced noise robust algorithm for fault location on double-circuit transmission line for the case of single line-to-ground (SLG) fault, which uses distributed parameter line model that also considers the mutual coupling effect. The proposed algorithm requires the voltages and currents from single-terminal data only and does not require adjacent circuit current data. The fault distance can be simply determined by solving a second-order polynomial equation, which is achieved directly through the analysis of the circuit. The algorithm, which employs the faulted phase network and zero-sequence network with source impedance involved, effectively eliminates the effect of load flow and fault resistance on the accuracy of fault location. The proposed algorithm is tested using MATLAB/Simulink under different fault locations and shows high accuracy. The uncertainty of source impedance and the measurement errors are also included in the simulation and shows that the algorithm has high robustness.
Wen-Hao Zhang,Umar Rosadi,Myeon-Song Choi,Seung-Jae Lee,Ilhyung Lim 대한전기학회 2011 Journal of Electrical Engineering & Technology Vol.6 No.1
This paper proposes an enhanced noise robust algorithm for fault location on double-circuit transmission line for the case of single line-to-ground (SLG) fault, which uses distributed parameter line model that also considers the mutual coupling effect. The proposed algorithm requires the voltages and currents from single-terminal data only and does not require adjacent circuit current data. The fault distance can be simply determined by solving a second-order polynomial equation, which is achieved directly through the analysis of the circuit. The algorithm, which employs the faulted phase network and zero-sequence network with source impedance involved, effectively eliminates the effect of load flow and fault resistance on the accuracy of fault location. The proposed algorithm is tested using MATLAB/Simulink under different fault locations and shows high accuracy. The uncertainty of source impedance and the measurement errors are also included in the simulation and shows that the algorithm has high robustness.
Protectability Evaluation for Overcurrent Relay based on a Probabilistic Method
Zhang, Wen-Hao,Lee, Seung-Jae,Choi, Myeon-Song The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.1
This paper proposes a probability measure for evaluation of relay performance from two aspects - correct trip and no-unwanted trip. They are developed based on the relationship between relay settings and relay measurements which follows a Gaussian probability model. The proposed method is applied to protection capability evaluation of overcurrent relays.
Zhang, Wen-Hao,Lee, Seung-Jae,Choi, Myeon-Song The Korean Institute of Electrical Engineers 2010 Journal of Electrical Engineering & Technology Vol.5 No.3
This paper proposes a probability measure for the evaluation of relay performance from two aspects, namely, correct trip and no-unwanted trip. They are developed based on the relationship between relay settings and relay measurements, which follow a Gaussian probability model. The proposed method based on strict mathematical derivation is applied to protection capability evaluation of distance relays under various settings. Considering the specific attributes of each protection zone, the optimal settings are also determined accordingly. The protection capability could demonstrate clearly the relay performance under various settings and the optimal settings could provide good references for engineering applications.
A Probabilistic Method Based Protectability Evaluation of Distance Relay in Transmission Networks
Zhang, Wen-Hao,Choi, Myeon-Song,Lee, Seung-Jae,Lim, Il-Hyung,Rim, Seong-Jeong The Korean Institute of Electrical Engineers 2008 Journal of Electrical Engineering & Technology Vol.3 No.3
This paper defines the concept of “protectability” for the performance evaluation of distance relay considering its sensitivity and selectivity. The paper starts from the probabilistic modeling of the errors, and based on this model, a detailed explanation of protectability calculation for each zone of the distance relay is presented. An effect of the Weighting Rate and the Measurement Deviation on the protectability evaluation is also given. By considering this effect, the optimization of relay setting can be realized. The proposed method is applied to a typical model system to show its effectiveness
Zhang Xiao-wen,Li Jing,Hou Wen-Bin,Jiang Yue,Zheng Ruo-Xiang,Xu De-hao,Shen Chen,Robinson Nicola,Liu Jian-Ping 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.1
Background: To explore the effectiveness and safety of Chinese herbal medicine (CHM) for drug-induced liver injury (DILI) in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syn- drome (AIDS). Methods: A systematic search was made of eight databases (Pubmed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang, VIP, Sinomed) and two trial registries (WHO ICTRP, ClinicalTrials.gov) from in- ception to September 2022. The effect size was presented as risk ratio (RR) or mean difference (MD) with their 95% confidence interval (CI). The Cochrane Risk of Bias and Grading of Recommendations, Assess- ment, Development and Evaluations (GRADE) tools were used for quality appraisal. Results: Ten randomized controlled trials (RCTs) involving 732 participants were included. Comparing CHM alone with routine treatment, the CHM group showed lower aspartate aminotransferase (MD = -11.47 U/L, 95%CI[-13.05, -9.89], low certainty), lower alanine aminotransferase (MD = -2.68 U/L, 95%CI[-4.27, - 1.08], low certainty), lower total bilirubin (MD = -4.31 mmol/L, 95%CI[-5.66, -2.96], low certainty), lower bilirubin direct (MD = -3.19 mmol/L, 95%CI[-3.87, -2.51], low certainty), and higher effective rate (assessed by symptoms and liver indicators) (RR = 1.13, 95%CI[1.06, 1.20], low certainty). A significant difference was also found in CHM plus routine treatment versus routine treatment in the previous outcomes. No signif- icant difference was found on helper T cells among these comparisons. Only one RCT reported safety of CHM and found no adverse reaction during the trial. Conclusions: CHM may improve the liver function indices and effective rate for HIV/AIDS patients with DILI. However, the sample size was small and quality was low. Larger-samples of high-quality trials are needed.