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a possible combined attenuation control of the inducible MLS resistance
최응칠,Weisblum, B. 한국미생물학회 1987 微生物과 産業 Vol.13 No.2
이글에서는 항생물질 내성의 생화학적 기전, MLS계 항생물질 내성기전, Post-transcriptional attenuation control, MLS계 항생물질 내성기전 연구방향, erm K의 cloning: transcriptional attenuation control의 가능성에 대해 논하였다.
An Improved and Efficient Method for Cosmid Cloning
LEE, BAEK-RAK,WEISBLUM, AERNARD 한국미생물 · 생명공학회 1994 Journal of microbiology and biotechnology Vol.4 No.3
A general improved procedure for preparation of a cosmid library based on the use of a pBLcosT vector was described. The vector was modified to contain 2 tandem Xcml sites and was digested with Xcml to yield 2 terminal 3'T overhangs, capable of ligation with the insert that contains 2 terminal complementary 3'A overhangs. The resultant ligation mixture was packaged and a cosmid library in Escherichia coli was established.
Bacillus licheniformis EMR 균주에서 린코사마이드계 항생물질에 의한 유도내성
최응칠(Eung Chil Choi),우정원(Jung Won Woo),B. 와이스브럼(Bernard Weisblum) 대한약학회 1986 약학회지 Vol.30 No.6
To clarify resistance mechanisms of lincosamide antibiotics, it was examined whether lincosamide antibiotics was able to induce high resistance to macrolide and lincosamide antibiotics against EMR-1 strain of Bacillus species. And it was also examined whether the inducible resistance was plasmid-mediated or chromosome-mediated. This strain was identified as Bacillus licheniformis by its morphological and physiological characteristics. The subinhibitory concentrations of lincomycin and clindamycin induced high resistance in the strain to lincosamide antibiotics, but not to macrolide antibiotics. The inducible resistance was not eliminated by treating the strain with ethidium bromide, and plasmid was not identified by the alkaline lysis method of plasmid preparation. These results indicate, therefore, that the inducible resistance to macrolide and lincosamide antibiotics in the strain may be chromosome-mediated, not plasmid-mediated.
Bacillus licheniformis EMR-1에서의 MLS 유도내성 기전 -erm K의 크로닝-
최응칠,곽진환,B.와이스브럼,Choi, Eung-Chil,Kwak, Jin-Hwan,Weisblum, Bernard 대한약학회 1988 약학회지 Vol.32 No.4
Inducible MLS resistance gene of Bacillus licheniformis specified by erm K was subcloned in Bacillus subtilis and the DNA sequence corresponding to its control region was determined. The determinant erm K was in Pvu II=Hind III fragment, which was 1.3 kb. The leader region is capable of forming a complex series of inverted complementary repeat sequences (ICRS) centering on at least six axes of symmetry, some of them mutually exclusive, in a way that resulted ultimately in post-transcriptional unmasking of the ribosome loading site for methylase synthesis.