Vibration reduction design of the Hangzhou Bay cable-stayed bridges

Liu, Weiqing,Xu, Xiuli,Wang, Rengui,Wang, Zijun,Wu, Xiaolan Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.3

Hangzhou Bay Bridge spans the Hangzhou Bay and is located at Zhejiang province in the southeast seacoast of China. The total length of the bridge is 36 km. The bridge is composed of bridge approaches made up of multi-span prestressed concrete box girders and two cable-stayed bridges over the north and south navigable spans respectively. The seismic response analysis of the bridge model shows that if the navigable spans are designed as the routine earthquake-resistance system, the displacements and internal forces in pylons, piers and deckes are too large to satisfy the anti-seismic requirement of the structure. Therefore, the seismic reduction design was carried out by using viscous dampers to dissipate the kinetic energy of the structure both longitudinally and transversely. Using the vibration reduction system and aiming at the reasonable optimal goal, the purpose to reduce the seismic responses in south and north navigable spans has been achieved.

Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition

( Lian Xu ),( Mengxia Fu ),( Dongrui Chen ),( Weiqing Han ),( Michael C. Ostrowski ),( Paul Grossfeld ),( Pingjin Gao ),( Maoqing Ye ) 생화학분자생물학회 2019 BMB Reports Vol.52 No.10

Cardiac fibrosis is a common feature in chronic hypertension patients with advanced heart failure, and endothelial-tomesenchymal transition (EndMT) is known to promote Angiotensin II (Ang II)-mediated cardiac fibrosis. Previous studies have suggested a potential role for the transcription factor, ETS-1, in Ang II-mediated cardiac remodeling, however the mechanism are not well defined. In this study, we found that mice with endothelial Ets-1 deletion showed reduced cardiac fibrosis and hypertrophy following Ang II infusion. The reduced cardiac fibrosis was accompanied by decreased expression of fibrotic matrix genes, reduced EndMT with decreased Snail, Slug, Twist, and ZEB1 expression, as well as reduced cardiac hypertrophy and expression of hypertrophy-associated genes was observed. In vitro studies using cultured H5V cells further confirmed that ETS-1 knockdown inhibited TGF- β1-induced EndMT. This study revealed that deletion of endothelial Ets-1 attenuated Ang II-induced cardiac fibrosis via inhibition of EndMT, indicating an important ETS-1 function in mediating EndMT. Inhibition of ETS-1 could be a potential therapeutic strategy for treatment of heart failure secondary to chronic hypertension. [BMB Reports 2019; 52(10): 595-600]

Characterization of phytochemical profile of rhizome of artificial cultured Polygonatum sibiricum with multiple rhizome buds

Cheng Weiqing,Pan Zhibin,Zheng Hanjing,Luo Gelian,Liu Zhibin,Xu Suli,Lin Junhan 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-

Rhizome of Polygonatum sibiricum is both a renowned traditional Chinese remedy and a commonly consumed delicacy. Due to the escalating demand and excessive overexploitation, there has been a growing interest in the artificial cultivation of this plant in recent years. To assess the therapeutic benefits of artificially cultivated P. sibiricum, it is crucial to identify and classify its phytochemical components, which are the primary bioactive compounds found in its rhizome. In this study, the phytochemical profile of an artificially cultivated P. sibiricum rhizomes with multiple rhizome buds (ACM) was characterized by using untargeted UHPLC-Q-Orbitrap-MS based approach. In addition, two-wild-types P. sibiricum rhizomes, namely the wild-type with multiple rhizome buds (WTM) and the wild-type with single rhizome bud (WTS), were used for comparison. A total of 183 phytochemicals, including 20 alkaloids, 48 flavonoids, 33 phenolic acids, and 82 terpenoids, were tentatively identified. Generally, the phytochemical profile of ACM was comparable to that of WTM and WTS. In specific, most of the identified alkaloids and phenolic acids, and approximately half of the identified terpenoids, were not significantly different. Notably, several phytochemicals with potent therapeutic properties, such as epiberberine, laetanine, sinapic acid, curcumenol, were present in ACM. Additionally, artificial cultivation increased the abundance of geniposide and naringenin, which have been linked to cardioprotective effects. These findings provide valuable insights for the future utilization of artificially cultivated P. sibiricum.

LDBAS: Location-aware Data Block Allocation Strategy for HDFS-based Applications in the Cloud

( Hua Xu ),( Weiqing Liu ),( Guansheng Shu ),( Jing Li ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.1

Big data processing applications have been migrated into cloud gradually, due to the advantages of cloud computing. Hadoop Distributed File System (HDFS) is one of the fundamental support systems for big data processing on MapReduce-like frameworks, such as Hadoop and Spark. Since HDFS is not aware of the co-location of virtual machines in the cloud, the default scheme of block allocation in HDFS does not fit well in the cloud environments behaving in two aspects: data reliability loss and performance degradation. In this paper, we present a novel location-aware data block allocation strategy (LDBAS). LDBAS jointly optimizes data reliability and performance for upper-layer applications by allocating data blocks according to the locations and different processing capacities of virtual nodes in the cloud. We apply LDBAS to two stages of data allocation of HDFS in the cloud (the initial data allocation and data recovery), and design the corresponding algorithms. Finally, we implement LDBAS into an actual Hadoop cluster and evaluate the performance with the benchmark suite BigDataBench. The experimental results show that LDBAS can guarantee the designed data reliability while reducing the job execution time of the I/O-intensive applications in Hadoop by 8.9% on average and up to 11.2% compared with the original Hadoop in the cloud.

Dimensionless study on dynamics of pressure controlled mechanical ventilation system

Yan Shi,Jinglong Niu,Maolin Cai,Weiqing Xu 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.2

Dynamics of mechanical ventilation system can be referred in pulmonary diagnostics and treatments. In this paper, to convenientlygrasp the essential characteristics of mechanical ventilation system, a dimensionless model of mechanical ventilation system is presented. For the validation of the mathematical model, a prototype mechanical ventilation system of a lung simulator is proposed. Through thesimulation and experimental studies on the dimensionless dynamics of the mechanical ventilation system, firstly, the mathematical modelis proved to be authentic and reliable. Secondly, the dimensionless dynamics of the mechanical ventilation system are obtained. Last, theinfluences of key parameters on the dimensionless dynamics of the mechanical ventilation system are illustrated. The study provides anovel method to study the dynamic of mechanical ventilation system, which can be referred in the respiratory diagnostics and treatment.

Dynamic Equivalent Modeling of Motors Based on Improved Hierarchical Clustering Algorithm

Xueshan Lin,Hongbin Wu,Bin Ye,Bin Xu,Weiqing Tao 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3

As the most important part of the power system load, the dynamic characteristics of motors are very important for power system simulation. The calculation is very large if all motors are modeled respectively. In order to reduce the amount of calculations, a dynamic equivalent modeling method of motors based on the improved hierarchical clustering algorithm is proposed in this paper. The two state parameters, the load rate and the product of inertia time constant and rotor resistance, are taken as clustering indexes. The improved hierarchical clustering algorithm is used to cluster dynamically the motors. And with the pseudo t 2 statistics, it can obtain the best clustering results. Then it establishes the dynamic multi-machine equivalent model after each motor group equivalent. With the example system, the simulation results show that the proposed dynamic equivalent method can keep the dynamic characteristics of models and improve the equivalent accuracy.

Experimental Research and Numerical Simulation of a Large-span Isolated Structure Considering Multi-dimensional Input Effects

Zhen-yuan Gu,Shu-guang Wang,Weiqing Liu,Dong-sheng Du,Wei-zhi Xu 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.4

Based on the shaking table test of 1:20 scale structural models of the large-span isolated and non-isolated flat grid structures under the action of horizontal-bidirectional (2D) and three-dimensional (3D) rare earthquake, the dynamic characteristics, including natural vibration frequency, damping ratio, the acceleration and displacement responses are investigated. The results show that the base isolation could significantly prolong the structural vibration periods and increase the damping ratio. The capacity of energy dissipation for the base-isolated structure can also be improved. The horizontal acceleration amplification factors (AAFs) of the structure can be reduced greatly due to the base isolation, which effectively reduces the vertical vibration of the large-span grid. Under the 3D seismic input, the horizontal AAF of each layer is greater than that under the 2D one, which illustrates that the vertical seismic input increases the horizontal dynamic response of the structure. Furthermore, the finite element models of the isolated and non-isolated structures were simulated. The experimental results are in good agreement with the numerical results. The parameter optimization of isolation bearings was conducted by using finite element software. The seismic response of each layer under different shear to weight ratios (μ) was analyzed. It can be found that the parameters of the isolation layer have an optimal range which makes the dynamic response of the structure reach a minimum value under the rare earthquake.

Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study

Wang Qi,Dai Huajie,Hou Tianzhichao,Hou Yanan,Wang Tiange,Lin Hong,Zhao Zhiyun,Li Mian,Zheng Ruizhi,Wang Shuangyuan,Lu Jieli,Xu Yu,Liu Ruixin,Ning Guang,Wang Weiqing,Bi Yufang,Zheng Jie,Xu Min 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3

Background and Purpose We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR). Methods We leveraged the summary statistics of GM (n=18,340 in the MiBioGen consortium), blood metabolites (n=115,078 in the UK Biobank), and stroke (cases n=60,176 and controls n=1,310,725 in the Global Biobank Meta-Analysis Initiative) from the largest genome-wide association studies to date. We performed bidirectional MR analyses to explore the causal relationships between the GM and stroke, and two mediation analyses, two-step MR and multivariable MR, to discover potential mediating metabolites. Results Ten taxa were causally associated with stroke, and stroke led to changes in 27 taxa. In the two-step MR, <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family, <i>Desulfovibrio</i> genus, apolipoprotein A1 (ApoA1), phospholipids in high-density lipoprotein (HDL_PL), and the ratio of apolipoprotein B to ApoA1 (ApoB/ApoA1) were causally associated with stroke (all <i>P</i><0.044). The causal associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were validated using the weighted median method in an independent cohort. The three GM taxa were all positively associated with ApoA1 and HDL_PL, whereas <i>Desulfovibrio</i> genus was negatively associated with ApoB/ApoA1 (all <i>P</i><0.010). Additionally, the causal associations between the three GM taxa and ApoA1 remained significant after correcting for the false discovery rate (all q-values <0.027). Multivariable MR showed that the associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were mediated by ApoA1 and HDL_PL, each accounting for 6.5% (<i>P</i>=0.028) and 4.6% (<i>P</i>=0.033); the association between <i>Desulfovibrio</i> genus and stroke was mediated by ApoA1, HDL_PL, and ApoB/ApoA1, with mediated proportions of 7.6% (<i>P</i>=0.019), 4.2% (<i>P</i>=0.035), and 9.1% (<i>P</i>=0.013), respectively. Conclusion The current MR study provides evidence supporting the causal relationships between several specific GM taxa and stroke and potential mediating metabolites.