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Scattering From Two Concentric Thick Conducting Cylindrical Cavity-Backed Apertures
Wang-Sang Lee,Hyeong-Seok Jang,Hyun-Sung Tae,Jong-Won Yu Institute of Electrical and Electronics Engineers 2014 IEEE Transactions on Antennas and Propagation Vol. No.
<P>An exact series solution for scattering and transmitting of two concentric thick conducting cylindrical cavity-backed apertures is formulated by using radial mode matching technique. The scattered and penetrated fields are represented in terms of an infinite series of radial modes. By applying the appropriate boundary conditions, the coefficients of scattered and transmitted fields are obtained. The behavior of resonance features is characterized for variation of structures with another slotted cylinder inside.</P>
Lee, Yeon Kyung,Choi, Jungil,Wang, Wenping,Lee, Soyoung,Nam, Tae-Hyun,Choi, Wan Sung,Kim, Chang-Joon,Lee, Jong Kwon,Kim, Sang-Hyun,Kang, Sang Soo,Khang, Dongwoo American Chemical Society 2013 ACS NANO Vol.7 No.10
<P>As the majority of side effects of current chemotherapies stems from toxicity due to excessive dosing of anticancer drugs, minimizing the amount of drug while maximizing drug efficacy is essential to increase the life-quality of chemotherapy patients. This study demonstrated that the intracellular delivery of amide linked doxorubicin on carbon nanotube can nullify the efflux of cancer cells by achieving prolonged endolysosome delivery and can induce burst release of doxorubicin in an acidic hydrolase environment and, ultimately, can reduce the amount of anticancer drug by 10-fold compared to conventional effective drug dose. The clearance of accumulated carbon nanotubes in the liver was observed after 4 weeks, and analysis of liver toxicity markers showed no significant changes in GOT and GPT levels and release of pro-inflammatory cytokines across both short- and long-term periods.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-10/nn4041206/production/images/medium/nn-2013-041206_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn4041206'>ACS Electronic Supporting Info</A></P>
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Lee, Jin-Ku,Liu, Zhaoqi,Sa, Jason K.,Shin, Sang,Wang, Jiguang,Bordyuh, Mykola,Cho, Hee Jin,Elliott, Oliver,Chu, Timothy,Choi, Seung Won,Rosenbloom, Daniel I. S.,Lee, In-Hee,Shin, Yong Jae,Kang, Hyun J Nature Pub. Co 2018 Nature genetics Vol.50 No.10
Lee, Kyung-Hoon,Wang, Tao,Jin, Yong-Cheng,Lee, Sang-Bum,Oh, Jin-Ju,Hwang, Jin-Hee,Lim, Ji-Na,Lee, Jae-Sung,Lee, Hong-Gu Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.2
The aims of study were to investigate the effects of intraperitoneal (i.p.) infusion of ghrelin on pancreatic ${\alpha}$-amylase outputs and the responses of pancreatic proteins to ghrelin that may relate to the pancreatic exocrine. Six male Sprague-Dawley rats (300 g) were randomly divided into two groups, a control group (C, n = 3) and a treatment group (T, $10.0{\mu}g/kg$ BW, n = 3). Blood samples were collected from rat caudal vein once time after one hour injection. The concentrations of plasma ghrelin, cholecystokinin (CCK) and alfa-amylase activity were evaluated by enzyme immunoassay (EIA) kit. Two-dimensional gel electrophoresis (2-DE) analysis was conducted to separate the proteins in pancreas tissue. Results showed that the i.p. infusion of ghrelin at doses of $10.0{\mu}g/kg$ body weight (BW) increased the plasma ghrelin concentrations (p = 0.07) and elevated the plasma CCK level significantly (p < 0.05). Although there was no statistically significant, the ${\alpha}$-amylase activity tended to increase. The proteomics analysis indicated that some pancreatic proteins with various functions were up- or down-regulated compared with control group. In conclusion, ghrelin may have role in the pancreatic exocrine, but the signaling pathway was still not clear. Therefore, much more functional studies focus on these found proteins are needed in the near future.
Wang, Liang,An, Dong-Shan,Kim, Song-Gun,Jin, Feng-Xie,Lee, Sung-Taik,Im, Wan-Taek Society for General Microbiology 2011 International journal of systematic and evolutiona Vol.61 No.12
<P>A novel gammaproteobacterium, designated LnR5-47(T), was isolated from soil of a ginseng field in Liaoning province, China. The isolate was a Gram-negative, aerobic, non-motile, non-spore-forming rod. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain LnR5-47(T) belonged to the genus Rhodanobacter. The isolate was most closely related to Rhodanobacter ginsengisoli GR17-7(T), Rhodanobacter terrae GP18-1(T), Dyella ginsengisoli Gsoil 3046(T), Rhodanobacter soli DCY45(T), Dyella soli JS12-10(T) and Dyella japonica IAM 15069(T) (98.0, 97.9, 97.7, 97.3, 97.2 and 97.1% 16S rRNA gene sequence similarity, respectively). Chemotaxonomic data (Q-8 as the predominant ubiquinone, and iso-C(16:0), iso-C(17:1)ω9c and iso-C(15:0) as the major fatty acids) also supported the affiliation of strain LnR5-47(T) with the genus Rhodanobacter. However, DNA-DNA relatedness between strain LnR5-47(T) and its closest phylogenetic neighbours was <25.8%. Moreover, physiological and biochemical tests phenotypically differentiated the isolate from other members of the genus Rhodanobacter. Therefore, strain LnR5-47(T) represents a novel species, for which the name Rhodanobacter panaciterrae sp. nov. is proposed; the type strain is LnR5-47(T) (=KACC 12826(T)=KCTC 22232(T)=LMG 24460(T)).</P>