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Linh Thi Thao Nguyen,송연우,Thao Anh Tran,김기석,김소미 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is aspecial form of apoptosis in which cells loose contact with othercells or the extracellular matrix. In the present study, we havefound that the breast cancer stem cell line MCF-7-SC, isolatedfrom MCF-7 breast cancer cells, shows characteristics of anoikisresistance. Treatment of supercritical CO2 extract from Citrushassaku Hort ex Tanaka, locally known as Phalsak, reduced theexpression of ATP-binding cassette sub-family G member 2mRNA and induced apoptosis in MCF-7-SCs, as evidenced by anincrease of apoptotic body formation, increased cell population inthe sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolyticactivation of caspase-9 and caspase-3, and the degradation ofpoly(ADP-ribose) polymerase (PARP) protein. The effects ofsupercritical CO2 extract from Phalsak on anoikis-resistant breastcancer stem cells suggest the use of this extract as a potentialtherapeutic agent for breast cancer stem cell treatment.
Nguyen, Linh Thi Thao,Song, Yeon Woo,Tran, Thao Anh,Kim, Ki-Seok,Cho, Somi Kim The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is a special form of apoptosis in which cells loose contact with other cells or the extracellular matrix. In the present study, we have found that the breast cancer stem cell line MCF-7-SC, isolated from MCF-7 breast cancer cells, shows characteristics of anoikis resistance. Treatment of supercritical $CO_2$ extract from Citrus hassaku Hort ex Tanaka, locally known as Phalsak, reduced the expression of ATP-binding cassette sub-family G member 2 mRNA and induced apoptosis in MCF-7-SCs, as evidenced by an increase of apoptotic body formation, increased cell population in the sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolytic activation of caspase-9 and caspase-3, and the degradation of poly(ADP-ribose) polymerase (PARP) protein. The effects of supercritical $CO_2$ extract from Phalsak on anoikis-resistant breast cancer stem cells suggest the use of this extract as a potential therapeutic agent for breast cancer stem cell treatment.
Thao T. D. Tran,Thinh D. Luu,Beom‑Jin Lee,Phuong H. L. Tran 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.1
Sprouted grains, which is a natural polysaccharide, is the subject of increasing scientific interest due to many benefits for human health. The aim of the present work was to develop sprouted rice (SR) as a safe and useful material for application in dissolution enhancement of anticancer poorly water-soluble drugs such as curcumin by solid dispersions (SDs). SDs were prepared with pure SR and modified sprouted rice (MSR) by the melting method. The dissolution rate, drug crystallinity changes, molecular interactions and wettability were characterized and compared between the formulations. The use of MSR could result in a promising system for improving the dissolution rate of poorly water-soluble drugs. MSR could induce a greater amorphous state and improved wettability of drugs for dissolution enhancement compared to SR. Although both SR and MSR showed hydrogen bonding interaction, insignificant differences between SR and MSR were observed. We found that the crystallinity, interactions and wettability of the drug were significantly affected and modulated by MSR.
A Survey on Face-based Cryptographic Key Generation
Thao Dang,Deokjai Choi (사)한국스마트미디어학회 2020 스마트미디어저널 Vol.9 No.2
Derivation cryptographic keys from human biometrics opens a new promising research area when it can be used efficiently for not only verification or recognition tasks, but also symmetric-key based applications. Among existing biometric traits, face is considered as the most popular biometrics since facial features are informative and discriminative. In this paper, we present a comprehensive survey of Face-based key generation (FKGS). First, we summarize the trend of FKGS researches and sum up the methods which play important roles in the proposed key generation systems. Then we present the evaluation and the general performance analysis; from that, we give a discussion about the advantages and disadvantages of surveyed studies to clarify the fundamental requirements and the main challenges when implementing FKGS in practice. Finally, an outlook on future prospects is given
Thao Truong-Dinh Tran,이범진,Phuong Ha-Lien Tran,박준범 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
For the quality evaluation of raw materials, the influence of various types of solvents on the polymorphic crystallization behaviors and dissolution rates of two sources of valsartan (VAL) from China and India was investigated. Samples were prepared by recrystallization from water or organic solvents, such as acetonitrile, acetone and ethanol, using methods with and without heating. Recrystallization behaviors were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Scanning electron microscopy (SEM) was also used to observe the morphology of samples. The dissolution rate of recrystallized samples in water was evaluated and compared to the original VAL sample. There were significant differences in morphology, crystal structure and dissolution rate among the samples recrystallized using organic solvents. VAL was transformed into another polymorphic form by the solvents and recrystallization conditions. These physical properties of VAL also differed between the two sources of VAL. Thus, the physicochemical differences of raw materials should be carefully considered in early dosage formulation approaches.
Thao Thi Phuong Nguyen,Hiroshi Amano 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Temperature is an important inorganic factor which affects on every aspect in life of phytoseiid mites in general including N. californicus in this study. Cumulative and short-term effects of temperature through different life stages (immature, mating and oviposition periods) on mating duration and total fecundity of N. californicus were investigated at temperatures of 18, 25, 30 and 350C with a photoperiod of 16L:8D. Throughout experiments, females mated once and egg production was observed until they stop oviposition.
Thao Nguyen, Nguyen Le,Park, Chan Yeong,Park, Jong Pil,Kailasa, Suresh Kumar,Park, Tae Jung The Royal Society of Chemistry 2018 New journal of chemistry Vol.42 No.14
<P>The use of the synergistic molecular assembly of an aptamer and cetyltrimethylammonium bromide (CTAB) on gold nanoparticles (AuNPs) is described for the selective and sensitive colorimetric recognition of As<SUP>3+</SUP> ions in water samples. The As<SUP>3+</SUP> ions coordinate with Ars-3 aptamer-AuNPs, causing aggregation in the presence of CTAB, which induces a red-shift in the surface plasmon resonance (SPR) band and a visual change in the color. The aptamer has shown a strong tendency to bind with As<SUP>3+</SUP> ions using CTAB as a binder, exhibiting good linearity between the absorption ratio (<I>A</I>650/<I>A</I>520) and the concentration of As<SUP>3+</SUP> ions (1.0-100 ppb) with a detection limit of 16.9 ppb. In contrast, other chemical species (metal ions and anions) did not induce these changes at all, and thus the aptasensor is highly specific for As<SUP>3+</SUP> ion sensing. The spectroscopic and TEM results show high selectivity for As<SUP>3+</SUP> ion sensing and the assay is completed within 30 min. The aptamer-AuNP-based colorimetric method illustrates the potential utility for screening As<SUP>3+</SUP> ion levels in real samples. The developed aptasensor was successfully applied for the detection of As<SUP>3+</SUP> ions in water and cosmetic samples, signifying its remarkable application for As<SUP>3+</SUP> ion sensing in real samples.</P>
Thao, Trinh Thi,Kim, Cheolyong,Hwang, Inseong Korean Society of Soil and Groundwater Environment 2017 지하수토양환경 Vol.22 No.1
Persulfate (PS) activated with nanosized zero-valent iron (NZVI) was tested as a reagent to remove phenol from groundwater. Batch degradation experiments indicated that NZVI/PS molar ratios between 1 : 2 and 1 : 5 were appropriate for complete removal of phenol, and that the time required for complete removal varied with different PS and NZVI dosages. Chloride ions up to 100 mM enhanced the phenol oxidation rate, and nitrate of any concentration up to 100 mM did not significantly affect the oxidation rate. NZVI showed greater performance than ferrous iron did as an activator for PS. A by-product was formed along with phenol degradation but subsequently was completely degraded, which showed the potential to attain mineralization with the NZVI/PS system. Tests with radical quenchers indicated that sulfate radicals were a predominant radical. The results of this study suggest that NZVI is a promising activator of PS for treating contaminated groundwater.
Thao Thi Nguyen,전태수,김재한,서영수,허무영 한국미생물학회 2017 The journal of microbiology Vol.55 No.7
Secreted proteins (secretomes) play crucial roles during bacterial pathogenesis in both plant and human hosts. The identification and characterization of secretomes in the two plant pathogens Burkholderia glumae BGR1 and B. gladioli BSR3, which cause diseases in rice such as seedling blight, panicle blight, and grain rot, are important steps to not only understand the disease-causing mechanisms but also find remedies for the diseases. Here, we identified two datasets of secretomes in B. glumae BGR1 and B. gladioli BSR3, which consist of 118 and 111 proteins, respectively, using mass spectrometry approach and literature curation. Next, we characterized the functional properties, potential secretion pathways and sequence information properties of secretomes of two plant pathogens in a comparative analysis by various computational approaches. The ratio of potential non-classically secreted proteins (NCSPs) to classically secreted proteins (CSPs) in B. glumae BGR1 was greater than that in B. gladioli BSR3. For CSPs, the putative hydrophobic regions (PHRs) which are essential for secretion process of CSPs were screened in detail at their N-terminal sequences using hidden Markov model (HMM) – based method. Total 31 pairs of homologous proteins in two bacterial secretomes were indicated based on the global alignment (identity ≥ 70%). Our results may facilitate the understanding of the species-specific features of secretomes in two plant pathogenic Burkholderia species.
Quantification of Allantoin in Yams (Dioscorea sp.) Using a <sup>1</sup>H NMR Spectroscopic Method
( Thao Quyen Cao ),( Dongyup Hahn ) 한국미생물생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5
Allantoin is an abundant component of yams and has been known as a skin protectant due to its pharmacological activities. In previous methods for allantoin determination using high-performance liquid chromatography (HPLC), the separation was unsatisfactory. We herein developed a 1H quantitative nuclear magnetic resonance (qNMR) method for quantification of allantoin in the flesh and peel of yams. The method was carried out based on the relative ratio of signals integration of allantoin to a certain amount of the internal standard dimethyl sulfone (DMSO<sub>2</sub>) and validated in terms of specificity, linearity (range 62.5-2000 μg/ml), sensitivity (limit of detection (LOD) and quantification (LOQ) 4.63 and 14.03 μg/ml, respectively), precision (RSD% 0.02-0.26), and recovery (86.35-92.11%). The method was then applied for the evaluation of allantoin in flesh and peel extracts of four different yams cultivated in Korea.