Surface Treatments : FATIGUE PROPERTIES OF 40Cr - STEEL AFTER LASER OVERLAPPING IRRADIATION

Tao Gu,Qingkui Cai 대한금속재료학회 ( 구 대한금속학회 ) 1995 Advanced Material and Processing Vol.1 No.-

Novel Method to Improve the Microstructure and Mechanical Properties of 45 Steel

Tao Gu,Shuaixin Zhang,Yuhong Zhao,Yurong Yang,Huafeng Liu,Li Wu,Jianhua Liu,Hua Hou 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.4

Aiming at the problems of poor hardenability and low mechanical strength of 45 steel after quenching and tempering atnormal pressure, 45 steel was quenched and tempered under high pressure. The microstructure of 45 steel after high pressurequenching and tempering was analyzed by optical microscope, scanning electron microscope and transmission electronmicroscope, its hardness and compressive strength were tested by hardness tester and electronic universal testing machine,and compared with samples treated by the same process under atmospheric pressure. The results show that uniform andcompact tempered sorbite can be obtained after high pressure quenching and tempering of 45 steel, and the precipitatedgranular carbides are finely dispersed, thus improving the mechanical properties of 45 steel. Under a pressure of 3 GPa,quenching at 900 °C for 15 min and 550 °C for 60 min tempering, the hardness and compressive yield strength of 45 steelwere 36.3 HRC and 971 MPa, respectively, which were respectively 25.17% and 20.77% higher than the corresponding valuesobtained with the same process under atmospheric pressure quenching and tempering. This work provides a new method toeffectively improve the mechanical properties of 45 steel.

Pathway and Network Analysis in Glioma with the Partial Least Squares Method

Gu, Wen-Tao,Gu, Shi-Xin,Shou, Jia-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Gene expression profiling facilitates the understanding of biological characteristics of gliomas. Previous studies mainly used regression/variance analysis without considering various background biological and environmental factors. The aim of this study was to investigate gene expression differences between grade III and IV gliomas through partial least squares (PLS) based analysis. The expression data set was from the Gene Expression Omnibus database. PLS based analysis was performed with the R statistical software. A total of 1,378 differentially expressed genes were identified. Survival analysis identified four pathways, including Prion diseases, colorectal cancer, CAMs, and PI3K-Akt signaling, which may be related with the prognosis of the patients. Network analysis identified two hub genes, ELAVL1 and FN1, which have been reported to be related with glioma previously. Our results provide new understanding of glioma pathogenesis and prognosis with the hope to offer theoretical support for future therapeutic studies.

Effect of Mechanical Alloying and Sintering Behavior on the Microstructure and Properties of NbMoTaWRe Refractory High Entropy Alloy

Tao Gu,Li‑Min Wang,Qiang Hu,Xiu‑Bing Liang,Dong‑Xing Fu,Yong‑Xiong Chen,Xin‑Ming Zhao,Yan‑Wei Sheng 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11

An equiatomic refractory high-entropy alloy (RHEA) NbMoTaWRe is prepared by mechanical alloying (MA) and sparkplasma sintering (SPS). The effects of mechanical alloying and sintering behaviors on the microstructure and propertiesof the RHEA are investigated. After ball-milling for 30 h, the metastable and supersaturated MA powders with the bodycenteredcubic (BCC) structure are obtained. Then, the MA powders are sintered using the SPS method under the sinteringtemperature range of 1700–1900 °C, and the C atoms and WC introduced by the MA process reacts with the metastable andsupersaturated Ta/Nb phase of the MA powers to form the face-centered cubic (FCC) structure (Nb, Ta)C particles alongthe BCC matrix boundaries during the SPS process. The NbMoTaWRe alloy sintered at 1800 °C consisted of BCC matrixand FCC-type (Nb, Ta)C particles has high compactness (porosity fraction is 0.32%), fracture strength (2630 MPa), plasticstrain (6.82%), and hardness (992 ± 20 HV). These excellent properties of this RHEA are mainly attributed to the combinationof multi-effects, including sintering densification, grain refinement strengthening from the refined sizes (3.80 μm) BCCmatrix, precipitation strengthening from the (Nb, Ta)C particles, solid solution strengthening from multi-principal elementsand interstitial solid solution strengthening from C atoms dissolving into BCC matrix.

Translation Teaching under the Background of Machine Translation

Gu Tao 한국외국어대학교 통번역연구소 2019 한국외국어대학교 통번역연구소 학술대회 Vol.2019 No.07

In recent years, the rapid development of computer technology and machine translation has pushed forward the advancement of translation and translation teaching. In fact, it is even said that the machine translation may take place of human in translation field. However, in the views of many experts, machine translation may be the trend of the future, but it will never replace the human translation, especially in the field of literary one. Although the running speed of computer has been and will be faster and faster, the establishment and operation of corpus really need a long time to finish. Nevertheless, machine translation can play its role in many occasions, particularly in technical translation and business translation. Thus, under this background, translation teaching should be largely reformed to meet the new challenge, including the teaching aim and design; the teaching process; as well as the requirement for teachers and students. First of all, the aim of the teaching should be adjusted. Traditionally, students have been required to be equipped with language competence, subject knowledge, and careful attitude generally. In the new era, things will be different. The changed purpose may the cultivation of the talent with complex ability who can both skillfully make use of translation software and have enough translation competence. Because of the fast emergence of various translation software, either teachers or students should keep up with the time in order to find and use the most suitable one for them. Second, to meet this need, the necessary courses of computer and machine translation should be added into current teaching curriculum. That is to say, no matter for teacher or for students, the mastery of relevant computer technique will be essential. To some degree, the students of science may have some strong points over the students of arts. As a result, the recruitment of some applicants with science background in high school may be more efficient. Next, with the subject knowledge and background information accessible in fingertips, the focus of basic knowledge cultivation should be shifted into how to get them instead of memorizing them, and into the setting of reasonable frame of knowledge. In addition, the critical thinking will be more and more important, which should also be trained in the process of translation learning and practice. Finally, given the future translation need of the market and society, different institutes also should make specific aims according to its own features.

Research on No-Contact Hydraulic Dynamic Seal Characteristic based on CFD

Gu Jun-tao,Zhang Yong-de 보안공학연구지원센터 2013 International Journal of Smart Home Vol.7 No.6

Improving MapReduce Performance by Data Prefetching in Heterogeneous or Shared Environments

Tao Gu,Chuang Zuo,Qun Liao,Yulu Yang,Tao Li 보안공학연구지원센터(IJGDC) 2013 International Journal of Grid and Distributed Comp Vol.6 No.5

Development of stress-tolerant transgenic plants via RNA metabolism control

Hunseung Kang,Tao Xu,Lili Gu,Min Kyung Kim,Su Jung Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Environmental stresses including drought, extreme temperatures, and high salinity are major factors that severely limit crop productivity worldwide. To overcome yield loss due to these environmental stresses, a large number of researches have been conducted to understand how plants respond to and adapt these environmental stresses. Posttranscriptional regulation as well as transcriptional regulation of gene expression is recognized as a key regulatory process in plant stress responses, and these cellular processes are regulated by diverse RNA-binding proteins (RBPs). Over the last years, we have extensively investigated the functional roles of RBPs that harbor an RNA-recognition motif at the N-terminal half and a glycine-rich region at the C-terminal half (glycine-rich RNA-binding proteins, GRPs), zinc finger-containing GRP, and cold shock domain proteins (CSDPs) in Arabidopsis thaliana, rice (Oryza sativa), wheat (Triticum aestivum), and rapeseed (Brasicca napus) under stress conditions. Our comparative analysis demonstrated that certain family members display RNA chaperone function during stress adaptation process in monocotyledonous plants as well as in dicotyledonous plants. These findings point to the importance of the regulation of mRNA metabolism in plant response to environmental stresses and shed new light on the practical application of these RBPs to develop stress-tolerant transgenic crops.

ZD1839 and Cisplatin Alone or in Combination for Treatment of a Nasopharyngeal Carcinoma Cell Line and Xenografts

Gu, Wei-Guang,Huang, Yan,Yuan, Zhong-Yu,Peng, Rou-Jun,Luo, Hai-Tao,He, Zhi-Ren,Wang, Shu-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

This study evaluated the effects of ZD1839, an orally active, selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, on nasopharyngeal carcinoma (NPC) both in vitro and in vivo. Influence of ZD1839 alone or combined with cisplatin on the NPC cell line CNE2 was detected by MTT assay with flow cytometry assessment of cell cycle distribution and apoptosis rates. Nude mice NPC xenografts were also used to evaluate the effects of ZD1839 alone or combined with cisplatin. The Student's t test evaluated statistical significance. ZD1839 alone or combined with cisplatin inhibited CNE2 cell line proliferation. ZD1839 induced CNE2 cell cycle arrest in the G1 phase, and higher concentrations induced apoptosis. Xenograft tumors were significantly smaller when treated with 200 mg/kg ZD1839, cisplatin, or cisplatin combined with 100 mg/kg ZD1839 than untreated controls. ZD1839 (200 mg/kg) alone showed good tumor inhibition effects, reduction of tumor weights, and smaller tumor volume without loss of body weight. ZD1839 (200 mg/kg) might provide a good and effective therapeutic reagent for NPC.

Targeting SHCBP1 Inhibits Cell Proliferation in Human Hepatocellular Carcinoma Cells

Tao, Han-Chuan,Wang, Hai-Xiao,Dai, Min,Gu, Cheng-Yu,Wang, Qun,Han, Ze-Guang,Cai, Bing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Src homology 2 domain containing (SHC) is a proto-oncogene which mediates cell proliferation and carcinogenesis in human carcinomas. Here, the SHC SH2-domain binding protein 1 (SHCBP1) was first established to be up-regulated in human hepatocellular carcinoma (HCC) tissues by array-base comparative genome hybridization (aCGH). Meanwhile, we examine and verify it by quantitative real-time PCR and western blot. Our current data show that SHCBP1 was up-regulated in HCC tissues. Overexpression of SHCBP1 could significantly promote HCC cell proliferation, survival and colony formation in HCC cell lines. Furthermore, knockdown of SHCBP1 induced cell cycle delay and suppressed cell proliferation. Furthermore, SHCBP1 could regulate the expression of activate extracellular signal-regulated kinase 1/2 (ERK1/2) and cyclin D1. Together, our findings indicate that SHCBP1 may contribute to human hepatocellular carcinoma by promoting cell proliferation and may serve as a molecular target of cancer therapy.