생약제제인 이공산(異功散)의 Cisplatin 유도 신장독성 보호 및 항산화 효과

Lee, Kyung-Tae,Ahn, Kyoo-Seok,Chang, Sung-Goo,Oh, Soo-Myung,Jung, Jee-Chang 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung-Tae Lee, Kyoo-Seok Ahn¹, Sung-Goo Chang², Soo-Myung Oh²and Jee-Chang Jung²¹College of Pharmacy, ²Oriental Medicine and ³College of Medicine, and East-West Medical Reserch Institute, Kyung Hee University, Seoul, Korea. Preventive and Antioxidative Effects of Crude Drug Preparation(E-kong-san) on Cisplatin Induced Nephrotoxicity. Proceedings of International Symposium on East-West Medicine, Seoul. 201-211, 1999. -Nephroprotective effects of a crude drug-prearation (E-kong-san) were determined from cisplatin on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on ciplatin-induced human renal cortical tissue. Levels of creatinine and blood ure nitrogen(BUN) in serum after administration of cisplatin(0.75mg/kg,i.p.) to E-kong-san(0.75g/kg/day,p.o.)-pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of E-kong-san significantly inhibited the loss of body weight of cisplatin injected rts. These findings suggest that E-kong-san on the cisplatin induced nephrotoxicity led us to investigate whether the effect of this water extract was a result of anti-oxidation. E-kong-san showed strong free radical scavenger activities on 1,1-dipheny1-2picrylhydrazil(DPPH) radical and xanthine/xanthine oxidase(XOD) generated superoxide anion radical(O2-). We further studied the effects of E-kong-san on lipid peroxidation in rat liver microsomes induced by enzymatic and nonenzymatic methods. E-kong-san exhibited significant inhibition on both ascorbic acid/Fe2+and ADP/NADPH/Fe3+ induced lipid peroxidation in rat liver microsomes. Based on these results, we suggest that-E-kong-san attenuate the cisplatin induced cytotoxicity and its mechanism can be eplained by antioxidant.

Semantics of 'Make' and 'Have'

Sung, Tae Soo 대한언어학회 1998 언어학 Vol.6 No.1

Sung, Tae-Soo. 1998. Semantics of 'Make' and 'Have'. Linguistics, 6-1, 459-486. This paper purports surveys the differences between English periphrastic causative verbs--make and have. For this, the dichotomy of direct causation and indirect causation will be utilized. Both direct causation and indirect causation emerge in make-constructions, while only direct causation emerges in have-constructions. In causative constructions, the existence of a causer implicates the existence of a causing event, the causing event implicates the existence of its caused event. In case of a direct causative construction, the causee is contained within the causing event in that the causer have direct influence upon its causee, while in case of an indirect causative constructions, the causee is excluded from the interpretation of the causing event. This constrast is can be semantically represented, respectively: direct causative construction (C (x(y)) CAUSE E(y(z)); indirect causative construction (C(x) CAUSE E(y(z)). This type of semantic representations can be applied to psychological causative constructions and ergative constructions, which involve causal meaning. (Namseoul University)

Case Variations in Korean Periphrastic Causative Constructions

Sung, Tae soo 대한언어학회 1999 언어학 Vol.7 No.1

Sung, Tae-Soo. 1999 Case Variations in Korean Periphrastic Causative Constructions. Linguistics, 7-1, 1-31. The case variation of the causee in Korean is argued to be examined under the assumptions of the pragmatic correlations between causer and causes. In some causative situations, the causer affects its causee very strongly: in others, the influence of the causer over its causee is weak, relatively. However, despite this kind of difference, we argue that 1) causative sentences share the same underlying structure whether they involve a NOM causee, a DAT causee, or an ACC causee (case-marked as '-ka', '-eke', or '-lul', respectively); 2) why the causee of Korean periphrastic causative constructions alternates with '-ka', '-eke', and '-lul' is that the seemingly structural cases play a role of delimiters. Among '-ka', '-eke', and '-lul', the latter two are regarded as delimiters. In this article, it is argued that the case-doubling in Korean periphrastic causative construction appears only as a side-effect in uttering a causative construction under a apecific situation. (Namseoul University)

한국어 '-어(서)' 구문

성태수 대한언어학회 2000 언어학 Vol.8 No.1

Sung, Tae-Soo. 2000. On Korean '-ese' Construction. Linguistics 8-1, 59-85. Korean morpheme '-e' can be substituted for '-ese', in which case '-ese' carries three kinds of meanings: causal, time-restricted, and motivational. More precisely to consider the three relations above, on the one hand, we can find that they have a lexical meaning of 'possessing' in common. On the other, '-ese' is assumed to be utilized as a kind of functional category, in that it stands for 'resultative meaning'. The '-ese' constructions include two events in a sentence, of which the first event accounts for a cause and the second represents its effect to the first event. Inserted to the end of the first clause representing a cause, '-ese' plays a role of connecting the first and the second clause representing an effect. '--ese' that is [+lexical] as well as [+functional] is an affix, combined with the lower lexical verb. This category will be called FP. The [+L, +F] category has a strong morphological property to be checked off by means of merging of '-ese' to the position of F. However, comparing Korean '-ese' constructions and Chinese '-de' constructions, we can find out a discrepancy that the identification of pro in the lower clause is under Tang (1998)'s GCT, in Chinese '-de' constructions, but not in Korean '-ese' constructions. The reason stems from a parameter that Korean '-ese' constructions, but not Chinese '-de' constructions, has an AgrP, immediately dominated by FP. (Namseoul University)

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

한국어 형용사와 ‘하’의 쓰임

성태수 남서울대학교 2012 남서울대학교 논문집 Vol.18 No.2

This paper discusses that Korean adjectives not only perform attributive or predicative functions as those of most other languages do but also involve tense markers and aspectual elements themselves without any verb. Korean '-ha' is claimed to be an affix that can derives adjectives, combined with other parts of speech containing stativity and scalar meaning in the underlying structure. In case Korean adjectives are used predicatively, they are combined with such makers as 'N(ㄴ)‘ or 'Ke(게)' attached to relative clauses and adverbial clauses. In case Korean adjectives are used attributively, on the other hand, '-ha' (as a derivative affix) is deleted in that they need not be combined with tense markers or aspectual elements; they do not have to lead a clause. Key Words : Key words: 형용사 (adjective), '하‘(ha), 수식적(attributive), 서술적 (predicative), 점층적 (scalar), 파생접사 (derivative affix), 상태성 (stativity), 동작성 (activity)

TOEIC 집중교육에 대하여

성태수 남서울대학교 2014 남서울대학교 논문집 Vol.20 No.1-2

Analysis of TOEIC Scores (Comparing Intensive Course with Regular Course) The purpose of this paper is to compare and analyze TOEIC scores of two kinds of courses opened at a university and the distribution of TOEIC scores of two groups. In addition, this paper will examine the ability of participants and the used instructional materials and equipment. The university has two kinds of TOEIC courses; one is a four-week intensive course opened in summer and winter vacations, where students participate in the classes from 9:00 a.m. to 4:00 p.m. The other is a regular TOEIC course, offering one-hour class every day from Monday to Friday during the university semester (15 weeks). This paper points out how important, the EFL/ESL teacher education, teaching materials, teaching methods and e-learning in operating more effective classes. The intensive TOEIC course and the regular TOEIC course include 120 hours and 75 hours a semester, respectively. Unfortunately, both courses have such a limited amount of time that students cannot achieve their fluent and perfect command of English. For Korean student to master English in a limited amount of both time and resources, the development of effective and qualitative EFL/ESL Intensive courses is essential.

비행위자주어에 대한 고찰

성태수 남서울대학교 2011 남서울대학교 논문집 Vol.17 No.2

In this article, we have attempted to solve two intricate problems about middle constructions, to reanalyze the middle formation conditions and unravel the mysteries about the paradoxical argument structure from three perspectives: what motivates such a "mismatched" argument structure, what licenses it and what makes it unique from others. The semantic function selects the argument structure; in turn it derives some specific restrictions on the construction as a whole as well as the individual lexical items in it. The proto-roles hypothesis enlightens us much as to the paradoxical language phenomenon. Middles involve a complex interplay between syntax, semantics and lexicon, and thus provide a rich source of data with which grammatical theories can be tested. Key Words : MISMATCHED, PROTO-ROLES HYPOTHESIS, AGENT

모바일 기반의 영어학습

성태수 남서울대학교 2015 남서울대학교 논문집 Vol.21 No.1-2