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Highly sensitive turn-on biosensors by regulating fluorescent dye assembly on liposome surfaces
Seo, Sungbaek,Kwon, Min Sang,Phillips, Andrew W.,Seo, Deokwon,Kim, Jinsang The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.50
<P>We developed a new self-signaling sensory system built on phospholipid liposomes having H-aggregated R6G dyes on their surface. Selective molecular recognition of a target by the phospholipid displaces R6G from the liposome surface to turn on fluorescence signal. Selective and sensitive detection of neomycin down to 2.3 nM is demonstrated.</P> <P>Graphic Abstract</P><P>Herein, we developed a turn-on type liposome-based sensing platform by assembling fluorescence dyes to form H-type aggregation with emission quenching on phospholipid-liposome surfaces. Rationally devised specific interactions between the phospholipid and a target analyte effectively release the fluorescence dyes from H-aggregate, producing a turn-on signal. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5cc01621e'> </P>
Removal of Microplastics via Natural Phenolics-Mediated Coagulation and Health Risk Assessment
Sungbaek Seo(서성백) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
In this presentation, microplastic coagulation using metal-phenolic coordinate bonds was used to improve microplastic removal efficiency. Plant-derived tannic acid contributed to interfacial bridging between the microplastics and Fe<SUP>3+</SUP>. Using 0.5 μm polystyrene beads as model microplastics, a removal efficiency of more than 90 % within 5 min was achieved. Since microplastics mostly accumulate in the gut of animals, rat intestine cells and tissues exposed to purified water from the microbead suspension were risk assessed, revealing that water purified using the coagulation-based method reduced oxidative stress and inflammatory cytokines to levels similar to those in cells exposed to water without microbeads.
서하규(Seo, Hakyu),한인수(Han, In-Su),정지훈(Jung, Jeehoon),김민성(Kim, Minsung),신현길(Shin, Hyungil),허태욱(Hur, Taeuk),조성백(Cho, Sungbaek) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.11
The coated metallic bipolar plates are getting attractive due to their good feasibility of mass production, low contact resistance, high electrical/thermal conductivity, low gas permeability and good mechanical strength comparing with graphite materials. Yet, metallic bipolar plates for polymer electrolyte membrane(PEM) fuel cells typically require coatings for corrosion protection. Other requirements for the corrosion protective coatings include low electrical contact resistance between metallic bipolar plate and gas diffusion layer, good mechanical robustness, low mechanical and fabrication cost. The authors have evaluated a number of protective coatings deposited on stainless steel substrate by electroplating. The coated metallic bipolar plates are investigated with an electrochemical polarization tests, salt dipping tests, adhesion tests for corrosion resistance and then the contact resistance was measured. The results showed that the selective samples electroplated with optimized method, satisfied the DOE target for corrosion resistance and contact resistance, and also were very stabilized in the typical fuel cell environments in the long-term.
Development and Evaluation of Gasket for Polymer Electrolyte Membrane Fuel Cell Stacks
서하규(Seo, Hakyu),한인수(Han, In-Su),정지훈(Jung, Jeehoon),김민성(Kim, Minsung),신현길(Shin, Hyungil),허태욱(Hur, Taeuk),조성백(Cho, Sungbaek) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.11
The design and fabrication of a metallic bipolar plate-gasket assembly for polymer electrolyte fuel cells (PEMFCs) is defined. This bipolar plate-gasket assembly was prepared by inserting a previously prepared bipolar plate in the specially designed gasket mold. For this aim, a proprietary fluoro-silicone based rubber was injected directly into the bipolar plate borders. Gaskets obtained like this showed the chemically / physically stable and the good sealibilty in typically operating PEM fuel cell conditions. And also, this bipolar plate-gasket assembly shows lots of advantages with respect to traditional PEMFCs stack assembling systems: useful application to automative stacking due to easy handling, reduced fabrication time, possibility of quality control and failed elements substitution. This bipolar plate-gasket assembly was evaluated in the short fuel cell stack and met the leakage requirement for normal operation both in short-term and in long-term operation. Especially, it was confirmed that this gasket could be applied successfully even in the high pressure FEM fuel cell systems(over 2.0 bar in absolute pressure).
Rapid Light-Driven Color Transition of Novel Photoresponsive Polydiacetylene Molecules
Lee, Jiseok,Seo, Sungbaek,Kim, Jinsang American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.4
<P>We developed new photoresponsive polydiacetylene (PR-PDA) molecules by incorporating a photocleavable moiety, 6-nitropiperonyl alcohol (NP) or 4,5-dimethoxy-2-nitrobenzyl alcohol (DMN), into a self-assembling diacetylene molecule. Inducing steric disordering of the assembled PDA molecules by the cleavage of the photoresponsive moiety under 365 nm UV irradiation results in color transition from blue to red and development of red fluorescence, allowing convenient photo patterning. Further writing and erasing of fluorescence patterns are demonstrated toward novel secure information communication and anticounterfeiting applications.</P>
Polydiacetylene-based Bead Gels as Colorimetric Sensor for Biogenic Amines Detection in Spoiled Food
Soojin JANG,Sungbaek SEO,Eun-Kyung LIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Biogenic amines (BAs), such as cadaverine, propylamine and putrescine, are released from every food, but they are especially released in spoilage foods. Small amounts of BAs have no effect on the human body, however large amounts can cause some problems. We have developed a colorimetric sensor that can easily determine the extent of spoilage food during distribution and storage. Polydiacetylene (PDA) has a unique color (blue) through a photopolymerization reaction and has a unique optical property of changing from blue to red when an external stimulus is applied. And, alginate is a natural polymer derived from brown algae, which has the properties of hardening when an alginate solution is added to calcium chloride solution, and is widely used as an additive such as pharmaceuticals and foodstuffs. Based on these characteristics, PDA-based bead gels were fabricated by simply mixing PDA-embedded liposome and alginate solution. And this is a colorimetric sensor, and the color changes from blue to red in the presence of BAs, so it can be easily checked with the naked eye.
Son, Seong Uk,Seo, Seung Beom,Jang, Soojin,Choi, Jongmin,Lim, Jae-woo,Lee, Do Kyung,Kim, Hyeran,Seo, Sungbaek,Kang, Taejoon,Jung, Juyeon,Lim, Eun-Kyung Elsevier 2019 Sensors and actuators. B Chemical Vol.291 No.-
<P><B>Abstract</B></P> <P>We have developed polydiacetylene (PDA)-based colorimetric biosensor for point-of-care testing (POCT) to detect high infectious pH1N1 virus among influenza A virus with the naked eye by color change. For this purpose, we first prepared PDA-PVDF membrane by immobilizing PDA onto the PVDF membrane through photo-polymerization, and then conjugated an antibody specifically binding to the influenza A virus into this membrane to form PDA-paper chips. This PDA-paper chips exhibited unique chromatic properties involving a color change from blue to red under various external conditions (temperature and pHs). Especially, we showed the color change of this paper chip in the presence of pH1N1 virus, confirming its potential as a POCT device. Furthermore, we have developed POCT systems based on PDA-paper chips by developing program, which is possible to visually detect viruses using only PDA-paper chips at a high concentration and detect and analyze them at low concentrations using both paper chips and program (App.). Further, this program will be updated to enable quantitative analysis of the virus.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This PDA-paper chips can detect pH1N1 virus directly with the naked-eye through color change. </LI> <LI> The detection sensitivity of PDA-paper chips is improved by disturbing the PDA matrix with temperature increase. </LI> <LI> PDA-paper chip as a colorimetric biosensor is suitable to use as point-of-care testing (POCT) device. </LI> </UL> </P>