Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

비만 개선 효과를 지닌 탄수화물 및 지방 흡수 억제 기능성 식이조성물 개발

윤유식,최선미,홍순복,홍정미,김정원,이홍석,홍성길 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

In a previous study, we developed a new food additive as an egg yolk antibody (IgY) against carbohydrate digestion enzymes for the regulation of blood glucose level and weight control. The IgY delayed and decreased the increment of blood glucose level after administration of sucrose in human being by 30% in 20∼30 min. We also developed a lipase inhibitor as a water extract of two kinds of herb, Platycodon grandiflorum and Solanum melongena. Twenty three volunteers were subjected to the intake of the egg yolk IgY plus the herbal extracts for 50 days. In average, the treated subjects appeared to lose 1.96 ㎏ of body weight and 3.4 ㎏ of body fat mass during the treated period. Furthermore, Panniculus adiposus and breech size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of egg yolk IgY and natural herbal extract improve the obesity by the decrement of body weight and body fat mass.

16S와 23S rRNA에 결합하는 Probe를 이용한 겨울철 소양호 세균 군집 구조의 분석

홍선희,변명섭,안태석 한국동물학회 1995 동물학회지 Vol.38 No.4

16S와 23S rRNA에 결합하는 probe를 이용한 겨울철 소양호 세균 군집 구조의 분석

홍선희,변명섭,안태석 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

겨울철 소양호에서 세균 군집 구조를 파악하고자 총세균수와 EUB338, ALF1b, BET4a, GAM42a와 CF probe등 fluorescent rRNA targeted oligonucleotide probe와 반응하는 세균 개체수를 수심별로 측정하였다. 총세균수는 0.7×10^(6)~1.1×10^(6)cell·㎖^(-1)이였으며, 5m와 10m 수층에서 높게 나타났다. 총세균수에 대한, Eubacteria의 비율은 34~90%이였으며, 5m와 10m에서 낮게 나타났다. Proteobacteria α-group은 Eubacteria의 10.8-28.7%, β-group은 4.5-53.5%, γ-group은 4.9-35.5%, 그리고 Cytophaga-Flavobacterium group은 6.1-21.1%이였다. 0.5m 수심에서는 β-group이 28.6-53.3%로 우점하고 있었으며, 10m에서는 γ-group이 35.5%로 우점하였다. 30, 50m 수심에서는 α-group과 Cytophaga-Flavobacterium group이 우점하였다. 세균 군집 구조로 보면 0-2m, 5-10m 그리고 30-50 m의 3개층은 각각 독특한 특징을 나타내었다. 이 방법으로 호수 생태계에 대한 새로운 정보를 얻을 수 있었다. To scrutinize the bacterial community composition of Lake Soyang in winter, bacterial numbers blonging to Eubacteria, Proteobacteria and Cytophaga-Flavobacterium group were estimated by using 16S and 23S rRNA targeted oligonucleotide probes. Total bacterial numbers ranged from 0.7Χ10^(6)~1.1Χ10^(6)cell ·㎖^(-1)and vertical profile of total bacteria showed a peak at 5m and 10m depths those were low exhibiting, 39 and 34%, respectively, The percentage of proteobacteria α-group ranged 10.8~28.7%, β-group 4.5~535%, Υ-group 4.9~35.5% and Cytophaga-Flavobacterum group 6.1~21.1%. The dominant groups were β-group at 0, 2 and 5m Υ-group at 10m, α-group at 30m and Cytophaga-Flavobacterium group at 50m depth. In winter season, Lake Soyang can be divided into into three layer, 0~2m, 5~20m and 30~50m, by bacteria community composition. By this method, new informations about aquatic ecostem were developed.

Flurescent In Situ Hybridization방법으로 분석한 소양호 세균 군집 구조의 졔절적 변화

홍선희,안태석 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

소양호에서 세균군집의 계절적, 수심별 변화를 파악하고자 총세균수와 EUB338, ALF1b, BET42a, GAM42a와 CF probe 등 fluorescent rRNA targeted oHgonucleotide probe와 반응하는 세균 개체수를 측정하였다. 총세균수는 0.5~2.01×10^(4)cell·㎖이였으며, 2m와 5m 수층에서 높게 나타났다. 총세균수에 대한 Eubacteria의 비율은 22~100%였고 Proteobacteria α-group은 Eubacteria의 2.6~66.7%, β-group은 4.5~53.5%, γ-group은 4.6~7.6%, 그리고 Cylophaga-Flavobacterium group은 2.1~35.9%이였다. 또한 세균군집은 계절별, 수심별로 다양한 변화를 보여, 겨울철을 β-group이, 봄철과 초여름철은 γ-group이, 여름철은 α-group이 우점하였고, Cytophaga-Flavobacterium group이 특징적으로 우점하는 시기는 없었다. 이러한 세균 군집 구조의 분포로 계절별, 수심별로 호수에 대한 독특한 특징을 알 수 있었다. To define the structure and diversity of bacterial communities in the aqutic ecosystem, Lake Soyang, the largest artificial reservoir in Korea, a new method, fluorescent in situ hybridization was applied. This technique relies on the specific hybridization of the nucleic acid probes to the naturally amplified intracellular rRNA. By this method, the bacterial community composition of Lake Soyang and bacterial numbers belong to eubacteria, proteobacteria and Cytophaga-Flavobacteria group were estimated. Total bacterial numbers ranged from 0.3×10^(6)~2.O×10^(6)cells · ml^(-1), and vertical profile of total bacteria showed the peak at 2 and 5 m depths. The ratio of eu-bacteria to total bacteria were 22~100% and varied wuth depth and season. The percentage of Prothobacteria α-group ranged 2.6~66.7%, β-group 4.5~ 53.5%, γ-group 4.6~70.7% and Cytophaga-Flavobacterium group 2.1~35.9%. Also, bacterial community had spatial and temporal characteristics. The dominant groups were β-group in winter, γ-group in spring and early summer and α-group in summer.

재발한 가와사끼병(Kawasaki disease) 1례

길홍량,한헌석,하태선,이경희,박범수 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.1

가와사끼병은 5세 미만의 영유아에서 호발하는 급성 전신성 혈관염으로 아직 원인이 밝혀지지는 않았으나 감염성질환 또는 자가면역질환 등으로 추정되고 있다. 1967년 일본의 Tomisaku Kawasaki에 의해 처음 보고되었으며 국내에서도 많은 증례보고가 있어왔다. 가와사끼병은 발열, 발진, 안결막 충혈, 사지말단의 변화, 구강과 입술의 변화, 경부 림프선증 등을 특징으로 하며, 치료로는 면역글로블린의 대량 정주요법과 아스피린이 사용되고 있으며 합병증에는 관상동맥류를 비롯한 심혈관질환이 있고 이로 인한 사망율이 1-2%정도인 것으로 보고되고 있다. 이 질환의 재발은 드문 것으로 되어 있고 일본의 한 보고에 의하면 2-3%로 추정된다. 환아는 6세 남아로 14개월 전 처음 가와사끼병으로 진단받고 감마글로블린과 아스피린을 투약 받았고 당시 심혈관질환은 없었으며 본원 내원시에는 발열, 발진, 안결막 충혈, 붉고 갈라진 입술, 좌측 림프선병증과 손, 발의 부종이 있어 가와사끼병의 진단기준을 만족하였다. 환아는 역시 감마글로블린과 아스피린으로 치료받고 증세가 호전되었으며, 심초음파 검사상 관상동맥의 확장이나 관상동맥류의 증거는 없었다. 저자들은 가와사끼병의 재발 1례를 경험하였기에 보고하는 바이다. Kawasaki disease, acute systemic vasculitis, that usually occurs in infant and young children. The etiology is unknown, but is supposed to be infectious disease or autoimmune disease. Kawasaki disease was first reprted by Tomisaku Kawasaki at 1967 and then many cases have been reported in Korea. Kawasaki disease was characterized by fever, rash, conjunctival injection, changes of extremities, changes of oral cavity and lips, lymphadenopathy and has been treated with intravenous gammaglobulin and aspirin. The complications are cardiovascular lesions including coronary aneurysm and coronary thrombosis. Mortality is approximately 1-2%. Recurrence is rare and 2-3% in Japanese reports. A 6-year-old boy presented with the fever, rash, conjunctivitis, red fissured lips, left lymphadenapathy, and hands and feet edema. He had been treated with intravenous gammaglobulin and aspirin for Kawasaki disease 14 months ago. At that time, he didn't have cardiovascular lesion. He was also treated with intravenous gammaglobulin and aspirin at this episode. We didn't detect coronary artery dilatation or coronary aneurysm. So, authors report a case of recurrent Kawasaki disease.

중간가공처리가 8090 Al-Li 합금의 파괴인성 및 응력부식균열성에 미치는 영향

맹선재,홍석주 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

Effect of cold working and aging treatment on the fracture toughness and stress corrosion cracking(SCC) sensitivity of 8090 Al-Li alloy has been studied. Fracture toughness was evaluated by Klc test using compact tension(CT) specimen. SCC sensitivity was evaluated by crack growth rate test in 3.5 wt% NaCl solution using single edge notched(SEN) specimen. Cold working prior to the aging treatment has resulted in decreased fracture toughness and increased SCC sensitivity. Peak aging decreased fracture toughness and increased SCC sensitivity compared to the underaged specimen. Aging treatment affected more largely on SCC sensitivity than cold working.

전신마취중 에피네프린사용으로 발생되는 부정맥

박선규,진홍용,양홍석 중앙대부설한국의과학연구소 1985 한국의과학 Vol.17 No.3

저선량 감마선 조사가 왕겨의 항산화능에 미치는 영향

정석문,김정한,김동열,육홍선,변명우,이승철 慶南大學校 附設 基礎科學硏究所 2002 硏究論文集 Vol.16 No.-

왕겨에 200, 400, 600, 800 및 1000 Gy의 저선량의 감마선을 조사하여 항산화능의 변화를 관찰하였다. 총 페놀 화합물의 양은 무처리구의 경우 0.184 mM를 나타내었고, 200 Gy로 감마선을 조사하였을 때는 0.215 mM로 약간 증가함을 보였으나 이후 차츰 감소하였다. 전자 공여능은 무처리구에 비해 처리구의 경우 조사 선량별로 조금씩의 차이만 있을 뿐, 조사 선량에 대한 왕겨의 전자 공여능은 유의적인 큰 변화 없이 비슷한 활성을 보였다. Fe^2+-ions 킬레이팅 활성은 무처리구의 경우 68.25%를 나타내었으며, 200, 400, 600 및 800 Cy 에서는 각각 86.45, 85.61, 86.65 및 82.84%로서 무처리구보다는 증가함을 보였으나, 1000 Gy에서는 74.67%로 감소하였다. 지질 과산화 억제능은 무처리구에 비해 처리구는 약간의 증가를 보였으나 효과는 미비하였다. We studied the effect of small-dose of γ-irradiation to rice hull(RH) for its antioxidant ability. The RH was treated with 200, 400, 600, 800, and 1000 Gy of γ-ray at 70 Gy/min. Total phenol amount of unirradiated RH was 0,184 mM, after irradiation at 200 Gy it increased to 0,215 mM, while irradiation above 400 Gy up to 1000 Gy decreased that to unirradiated level. The electron donating ability of RH did not show significant change depend on irradiation. The chelating ability for Fe^2+ of unirradiated RH was 68.25 %, while that of 200, 400, 600 and 800 Gy irradiated RH showed 86.45, 85.61, 86.65 and 82.84 % respectively, but, 1000 Gy was decreased to 74.67 %. According to TBARS analyses, inhibition ability of lipid peroxidation by RH was not affected by γ-irradiation.