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- 저자 : Sukhpal S (검색결과 4 건)
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Amrit Pal,Sukhpal Singh Chatha,Hazoor Singh Sidhu 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.3
Due to rising attention towards environmental and ecological issues caused by mineral oil-based lubricants in machining operations, the developing of an environmental favourable lubricant has become inevitable. As environmental favourable cutting fluids, vegetable oils have acquired great attention in machining operations due to their good biodegradability, nontoxicity and less environmental pollutant properties. Nowadays, the minimum quantity lubrication (MQL) technique is explored as alternative technique to conventional flood cooling technique. However, very limited work is done to investigate the effect of MQL technique using vegetable oils as the base oil for machining of hard materials. Moreover, systematic comparison of different vegetable oils as the base oil will be of great significance to the manufacturing industry. Therefore, in this study, the performance of six vegetable oils viz. castor, coconut, soybean, canola, palm and sunflower oil, and distilled water has been investigated during drilling of stainless steel (AISI 321) using minimum quantity lubrication technology. The main objective of this study is to compare the performance of various cooling strategies viz. dry, flood and seven MQL conditions with respect to drilling characteristics (thrust force, torque, surface roughness, coefficient of friction (COF), chip morphology and wear mechanism) in the drilling of stainless steel (AISI 321) by using HSS drill tools. Experimental findings showed that MQL drilling conditions have given excellent drilling performance by improving drilling characteristics than dry and flood drilling. Among the MQL fluids, sunflower oil provided better lubrication and improved the drilling characteristics followed by palm, canola, soybean, coconut, castor oil and distilled water. Sunflower oil had a thrust force, torque, surface roughness and coefficient of friction of 1425 N, 22.8 Nm, 4.356 μm and 4.000 μ, which reduced by 21.27%, 25.49%, 30.72% and 5.35%, respectively than that under flood drilling at 30th hole. The better lubrication performance of sunflower oil may be attributed to the rich presence of saturated-fatty acids. In addition, vegetable oils based MQL technique is more worthy to improve the cooling capabilities and promote sustainability in the manufacturing sector by saving resources and extending environmental benefits.
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The Mammalian Ste20-like Kinase 2 (Mst2) Modulates Stress-induced Cardiac Hypertrophy
Zi, Min,Maqsood, Arfa,Prehar, Sukhpal,Mohamed, Tamer M. A.,Abou-Leisa, Riham,Robertson, Abigail,Cartwright, Elizabeth J.,Ray, Simon G.,Oh, Sangphil,Lim, Dae-Sik,Neyses, Ludwig,Oceandy, Delvac American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.35
<P>The Hippo signaling pathway has recently moved to center stage in cardiac research because of its key role in cardiomyocyte proliferation and regeneration of the embryonic and newborn heart. However, its role in the adult heart is incompletely understood. We investigate here the role of mammalian Ste20-like kinase 2 (Mst2), one of the central regulators of this pathway. <I>Mst2</I><SUP>−/−</SUP> mice showed no alteration in cardiomyocyte proliferation. However, <I>Mst2</I><SUP>−/−</SUP> mice exhibited a significant reduction of hypertrophy and fibrosis in response to pressure overload. Consistently, overexpression of <I>MST2</I> in neonatal rat cardiomyocytes significantly enhanced phenylephrine-induced cellular hypertrophy. Mechanistically, Mst2 positively modulated the prohypertrophic Raf1-ERK1/2 pathway. However, activation of the downstream effectors of the Hippo pathway (Yes-associated protein) was not affected by Mst2 ablation. An initial genetic study in mitral valve prolapse patients revealed an association between a polymorphism in the human <I>MST2</I> gene and adverse cardiac remodeling. These results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart.</P>
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Vikas Kumar Singh,Priti Upadhyay,Pallavi Sinha,Ashish Kumar Mall,Ranjith K. Ellur,Atul Singh,Sanjay K.Jaiswal,Sunil Biradar,S. Ramakrishna,R.M. Sundaram,Ilyas Ahmed,B. C. Viraktamath,C. Kole,Sukhpal S 한국작물학회 2011 Journal of crop science and biotechnology Vol.14 No.1
A total of six TGMS (thermosensitive genic male sterile lines) and nine pollinator lines were subjected to molecular characterization using 48 genome-wide SSR (simple sequence repeat) markers. Cluster analysis revealed clear differentiation among the TGMS lines according to their source of origin. The SSR-based genetic distance between the hybrids of the parental lines ranged from 0.36to 0.79 suggesting a high degree of genetic divergence. Among a set of 54 hybrids generated using parental lines, 32 showed better parent heterosis (+21.7%) while 19 showed mid-parent heterosis (+15.0%). For the trait yield per plant genetic distance (GD) was negatively correlated with F1 performance (r = -0.202), mid-parent heterosis (r = -0.325*; P < 0.05), and better parent heterosis (r = -0.261), while it was positively correlated with specific combining ability (r = 0.042). Based on the grouped genetic distance (GGD),the hybrid combinations were divided into four groups. The GGD showed linear correlation with hybrid performance within the group (GGD = 40 - 50: r = -0.07; GGD = 70 - 80: r = 0.32). This information can be utilized in the development of higher yielding,two-line rice hybrids through selection of intermediately diverse parental lines using GGD.
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