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차용훈,김일수,김하식,이연신,김덕중,성백섭,서준열 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.6
In order to achieve effective prediction of residual stresses, the series experiment were carried out and the residual stress-es were measured using the backpropagation algorithm from the neural network and the sectional method. Using the experimental results, the optiomal control algorithms using a neural network should be developed in order to reduce the effect of the external disturbances on residual stresses during GMA welding processes. The results obtained from the comparison between the measured and calculated results, showed that the neural network based on backpropagation algorithm can be used in order to control weld quality. This system can not only help to under-stand the interaction between the process parameters and residual stress, but also, improve the quantity control for welded structures. The development of the system is goal in this study.
Comparison of surgical-site infection between open and laparoscopic appendectomy
Yong Joon Suh,Seung-Yong Jeong,Kyu Joo Park,Jae-Gahb Park,Sung-Bum Kang,Duck-Woo Kim,Heung-Kwon Oh,Rumi Shin,Ji Sun Kim 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.82 No.1
Purpose: An inflamed appendix can be removed either openly (open appendectomy [OA]) or laparoscopically (laparoscopic appendectomy [LA]). Surgical-site infection (SSI) is a representative healthcare-associated infection and can impose serious economic burdens on patients as well as affect morbidity and mortality rates. The aim of this study was to compare LA with OA in terms of SSI. Methods: The medical records of 749 patients (420 males; mean age, 33 years) who underwent appendectomy (OA, 431; LA, 318) between September 1, 2008 and April 29, 2010 were retrospectively reviewed for demographic and pathologic characteristics, recovery of bowel movement, length of hospital stay, and postoperative complications. Results: The frequency of purulent/gangrenous or perforated appendicitis was not significantly different between LA and OA groups (83% [263/318 cases] vs. 83% [359/431 cases], P = 0.183). The time to first flatus after surgery was not significantly different between the two groups (1.38 ± 1.07 days for LA, 1.33 ± 0.90 days for OA, P = 0.444), but the length of hospital stay was significantly shorter in LA group than in OA group (3.37 ± 0.12 days vs. 3.83 ± 0.12 days, P = 0.006). The frequency of overall SSI was not significantly different between the two groups (2.8% for LA, 4.6% for OA, P = 0.204), but that of superficial incisional SSI was significantly lower in LA group (0.6% vs. 3.9%, P = 0.016). Conclusion: The results of this study suggest that LA may lead to a shorter length of hospital stay and may have a lower risk of superficial incisional SSI than OA.
( Jong Joon Lee ),( Soo Kyung Park ),( Oh Sang Kwon ),( In Sik Won ),( Dong Kyu Kim ),( Young Kul Jung ),( Yang Suh Ku ),( Yun Soo Kim ),( Duck Joo Choi ),( Ju Hyun Kim ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.1
Background/Aims: Transforming growth factor beta1 (TGF-β1) is a key cytokine in the production of extracellular matrix. A genetic polymorphism at codon 10 of the TGF-β1 gene is associated with liver fibrosis. We investigated the effect of genetic polymorphisms at codon 10 on the development of alcoholic liver cirrhosis (ALC). Methods: In total, 119 controls and 182 patients with ALC, were enrolled in the study. Clinical and laboratory data including total lifetime alcohol intake were collected at enrollment. The genotype at codon 10 was determined for each patient by single-strand conformation polymorphism. Results: There were three types of genetic polymorphism at codon 10: homozygous proline(P/P), heterozygous proline/leucine(P/L), and homozygous leucine(L/L). Among the controls, the proportions of P/P, P/L, and L/L were 26.1%, 44.5%, and 29.4%, respectively in the ALC group, these proportions were 23.1%, 43.4%, and 33.5%, respectively. The genotype distribution did not differ between the controls and the ALC group. In the ALC group, age, total lifetime alcohol intake, and distribution of Child-Pugh class did not differ with the genotype. Of the male patients with ALC (n=164), the proportions of P/P, P/L, and L/L were 20.1%, 44.5%, and 35.4%, respectively the genotype distribution did not differ between the male controls and the male ALC patients. Conclusions: The genotype at codon 10 in TGF-β1 does not appear to influence the development of ALC. Further study is needed to investigate other genetic factors that influence the development of ALC in patients with chronic alcohol intake.
Bae, Hae-Rahn,Suh, Duck-Joon,Lee, Sang-Ho The Korean Physiological Society 1994 대한생리학회지 Vol.28 No.2
Using the methods of stopped-flow and epifluorescence microscopy with entrapped fluorophore, membrane permeability of $NH_3$ and weak acids in liposomes, renal brush border (BBMV) and basolateral membrane vesicles (BLMV), and primary culture cells from renal proximal tubule was measured. Permeability coefficient (cm/sec) of $NH_3$ was $(2.9{\times}10^{-2}$ in phosphatidylcholine liposome $25^{\circ}C)$, $5.9{\times}10^{-2}$ in renal proximal tubule cell $(37^{\circ}C)$, $4.0{\times}10^{-2}\;and\;2.4{\times}10^{-2}$ in BBMV and BLMV $(25^{\circ}C)$, respectively. Formic acid has the highest permeability coefficient among the weak acids tested, which was $4.9{\times}10^{-3}$ in liposome, $5.0{\times}10^{-3}$ in renal proximal tubule cell, $9.1{\times}10^{-3}$ in BBMV and $3.8{\times}10^{-3}$ in BLMV. There was a linear relationship between external concentration of nonionized formic acid and initial rate of flux of formic acid in liposome, and the slope coincided with the value of permeability coefficient of formic acid measured in pH 7.0. These results show that techniques of stopped-flow and epifluorescence microscopy with entrapped fluorophore provide the precise method of measurement of very rapid transport of nonelectrolytes through membranes with the advantages of instantaneous mixing effect, good resolution time and easy manipulation.
Sang-Yong Son,Nam-Joon Yi,Geun Hong,Hyeyoung Kim,Min Su Park,Young Rok Choi,Kyung-Suk Suh,Duck-Woo Kim,Seung-Yong Jeong,Kyu-Joo Park,Jae-Gahb Park,Kuhn-Uk Lee 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.4
Backgrounds/Aims: Hepatic resection has only guaranteed long-term survival in patients with colorectal liver metastasis (CRLM) even in the era of effective chemotherapy. The definite role of neoadjuvant chemotherapy (NCT) is to improve outcomes of unresectable CRLMs, but it its role has not been defined for initially resectable CRLMs (IR-CRLMs). Methods: We reviewed the medical records of 226 patients, who had been diagnosed and treated for IR-CRLM between 2003 and 2008; the patients had the following pathologies: 10% had more than 4 nodules, 11% had tumors larger than 5 cm, and 61% had synchronous CRMLs. Among these patients, 20 patients (Group Y) were treated with NCT, and 206 (Group N) did not receive NCT according to their physician’s preference. The median follow-up time was 34.1 months. Results: The initial surgical plans were changed after NCT to further resection in 20% and to limited resection in 10% of 20 patients. Complication rates of Groups Y (30%) were indifferent from Group N (23%) (p=0.233), but intraoperative transfusions were more frequent in Group N (15%) than in Group Y (5%) (p=0.006). There was one case of hospital mortality (0.44%). Disease-free survival rates in Groups Y and N were 23% and 39%, respectively, and patient survival rates were 42% and 66% (p>0.05). By multivariate analysis, old age (≥60 years), differentiation of primary tumor (poorly/mucinous), resection margin involvement, and no adjuvant chemotherapy were associated with poor patient survival; the number of CRLMs (≥4) was associated with poor disease-free survival. Conclusions: NCT had neither a positive impact nor a negative impact on survival, even with intraoperative transfusion, as observed on operative outcomes for patients with IR-CRLM. Further study is required to elucidate the role of NCT for treatment of patient with IR-CRLMs. (Korean J Hepatobiliary Pancreat Surg 2011;15:206-217)
Bae. Hae-Rahn,Suh. Duck-Joon,Lee. Sang-Ho 대한생리학회 1994 대한생리학회지 Vol.28 No.2
Using the methods of stopped-flow and epifluorescence microscopy with entrapped fluorophore, membrane permeability of NH<sub>3</sub> and weak acids in liposomes, renal brush border (BBMV) and basolateral membrane vesicles (BLMV), and primary culture cells from renal proximal tubule was measured. Permeability coefficient (cm/sec) of NH<sub>3</sub> was (2.9 X 10<sup>-2</sup> in phosphatidylcholine liposome 25℃), 5.9 X 10<sup>-2</sup> in renal proximal tubule cell (37℃), 4.0 X 10<sup>-2</sup> and 2.4 X 10<sup>-2</sup> in BBMV and BLMV (25℃), respectively. Formic acid has the highest permeability coefficient among the weak acids tested, which was 4.9 X 10<sup>-3</sup> in liposome, 5.0 X 10<sup>-3</sup> in renal proximal tubule cell, 9.1 X 10<sup>-3</sup> in BBMV and 3.8 X 10<sup>-3</sup> in BLMV. There was a linear relationship between external concentration of nonionized formic acid and initial rate of flux of formic acid in liposome, and the slope coincided with the value of permeability coefficient of formic acid measured in pH 7.0. These results show that techniques of stopped-flow and epifluorescence microscopy with entrapped fluorophore provide the precise method of measurement of very rapid transport of nonelectrolytes through membranes with the advantages of instantaneous mixing effect, good resolution time and easy manipulation.