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Lee, Subin,Alkathiri, Badriah,Kwak, Dongmi,Lee, Sang-Myeong,Lee, Wan-Kyu,Byun, Jae-Won,Lee, Seung-Hun The Korea Society for Parasitology and Tropical Me 2022 The Korean Journal of Parasitology Vol.60 No.3
This study aimed to examine the distribution of gastrointestinal parasitic infections in domestic pigs in the Republic of Korea. From May 2020 to October 2021, 364 pig fecal samples were collected from 75 farms in 7 Provinces and microscopically examined. A total of 170 (46.7%) pigs were infected with at least one of the following parasites: Balantioides coli, strongyles, Ascaris suum, Trichuris suis, and coccidia. By parasite species, B. coli, strongyles, A. suum, T. suis, and coccidia oocysts or eggs were detected in 144 (39.6%), 24 (6.6%), 14 (3.8%), 4 (1.1%), and 1 (0.3%) samples, respectively. One hundred fifty-four, 15, and 1 cases showed single, double, and triple infections, respectively. Of the swine fecal samples from 75 farms, 69 specimens (92.0%) were infected with 1 or more parasites. All surveyed farms across the country exhibited a positive rate of over 30%, among which the highest positive rate was 65.0% in Chungcheongnamdo, and Jeollabuk-do was followed by 61.9%. Winter showed a statistically lower prevalence than other seasons. This study showed that gastrointestinal parasites are prevalent in pigs in Korea, although the diversity of parasites is low.
Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics
Lee, Min Hee,Sharma, Amit,Chang, Min Jung,Lee, Jinju,Son, Subin,Sessler, Jonathan L.,Kang, Chulhun,Kim, Jong Seung The Royal Society of Chemistry 2018 Chemical Society reviews Vol.47 No.1
<P>Theranostic systems are receiving ever-increasing attention due to their potential therapeutic utility, imaging enhancement capability, and promise for advancing the field of personalized medicine, particularly as it relates to the diagnosis, staging, and treatment of cancer. In this Tutorial Review, we provide an introduction to the concepts of theranostic drug delivery effected <I>via</I> use of conjugates that are able to target cancer cells selectively, provide cytotoxic chemotherapeutics, and produce readily monitored imaging signals <I>in vitro</I> and <I>in vivo</I>. The underlying design concepts, requiring the synthesis of conjugates composed of imaging reporters, masked chemotherapeutic drugs, cleavable linkers, and cancer targeting ligands, are discussed. Particular emphasis is placed on highlighting the potential benefits of fluorogenic reaction-based targeted systems that are activated for both imaging and therapy by cellular entities, <I>e.g.</I>, thiols, reactive oxygen species and enzymes, which are present at relatively elevated levels in tumour environments, physiological characteristics of cancer, <I>e.g.</I>, hypoxia and acidic pH. Also discussed are systems activated by an external stimulus, such as light. The work summarized in this Tutorial Review will help define the role fluorogenic reaction-based, cancer-targeting theranostics may have in advancing drug discovery efforts, as well as improving our understanding of cellular uptake and drug release mechanisms.</P>
Prevalence of DSM-IV Major Psychiatric Disorders among North Korean Defectors in South Korea
Lee Kyoung Eun,Moon Carolyn Seungyoun,An Ji Hyun,Lee Hyo Chul,Kim Da Eun,Park Subin,Lee Minji,Chang Hye In,Hong Jin Pyo 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.6
Objective The aim of this study was to estimate the prevalence of major psychiatric disorders among North Korean defectors (NKD) settled in South Korea.Methods The study population consisted of 294 North Korean defectors, aged 18 to 64 years settled in South Korea for 3 years or less. Between June 1, 2016 and October 31, 2016, face-to-face interviews were conducted using the North Korean version of the WHO-Composite International Diagnostic Interview (NK-CIDI) to diagnose DSM-IV psychiatric disorders.Results The lifetime prevalence of any DSM-IV psychiatric disorders was 62.2% in NKD and 25.0% in the general Korean population. The prevalence of specific disorders in NKD and general Korean population was as follows: 22.3% and 4.9% for major depressive disorder (MDD), 12.2% and 1.4% for post-traumatic stress disorder (PTSD), 18.0% and 4.8% for nicotine dependence, and 14.5% and 11.2% for alcohol abuse. The incidence of every single psychiatric disorder varied in each country. For instance, the generalized anxiety disorder, specific phobia, and alcohol use disorder occurred more frequently in North Korea whereas PTSD was more prevalent in other countries.Conclusion The prevalence of psychiatric disorders among NKD was quite higher than in the general population of South Korea.
SuBin Lee,YuJin Jung,SueRan Choi 한국색채학회 2017 AIC 2017 Jeju Vol.2017 No.10
The color of the exterior wall of the apartment and the complex is an important factor that greatly influences the visual image of regions, as well as cities of our country. However, the color of a relatively large number of brand apartments is dominant and there are many partial color schemes that do not take the overall harmony with the surrounding landscape, mountains, and rivers into consideration for the color of the exterior walls of apartments with uncertain regional and landscape identity. Although Sangye Byeoksan Apartment is surrounded by Mt. Buram and is in a railway station sphere incorporating a modern commercial complex, its image is somewhat negative because of the dark surroundings. Therefore, this study was performed to enhance Byeoksan Apartment’s identity through the use of nature-friendly color arrangement by investigating and analyzing the color of the objects of the surrounding natural environment and landscape. As a result of analyzing the colors of the target area, it was possible to extract various tones and colors from Mt. Buram, which is a relatively outside, rather than inside view. We proposed the apartment exterior wall color scheme by arranging extracted colors with dominant color, auxiliary color, and highlight color.
Lee, Jaehong,Shin, Sera,Lee, Sanggeun,Song, Jaekang,Kang, Subin,Han, Heetak,Kim, SeulGee,Kim, Seunghoe,Seo, Jungmok,Kim, DaeEun,Lee, Taeyoon American Chemical Society 2018 ACS NANO Vol.12 No.5
<P>Highly stretchable fiber strain sensors are one of the most important components for various applications in wearable electronics, electronic textiles, and biomedical electronics. Herein, we present a facile approach for fabricating highly stretchable and sensitive fiber strain sensors by embedding Ag nanoparticles into a stretchable fiber with a multifilament structure. The multifilament structure and Ag-rich shells of the fiber strain sensor enable the sensor to simultaneously achieve both a high sensitivity and largely wide sensing range despite its simple fabrication process and components. The fiber strain sensor simultaneously exhibits ultrahigh gauge factors (∼9.3 × 10<SUP>5</SUP> and ∼659 in the first stretching and subsequent stretching, respectively), a very broad strain-sensing range (450 and 200% for the first and subsequent stretching, respectively), and high durability for more than 10 000 stretching cycles. The fiber strain sensors can also be readily integrated into a glove to control a hand robot and effectively applied to monitor the large volume expansion of a balloon and a pig bladder for an artificial bladder system, thereby demonstrating the potential of the fiber strain sensors as candidates for electronic textiles, wearable electronics, and biomedical engineering.</P> [FIG OMISSION]</BR>
Subin Yoon,Yuna Cho,Kyunglee Lee,Se Ra Lim,Seon Young Park,Hyemin Kwon,Ye Seul Lee,Jee Eun Han,김지형 한국미생물학회 2020 미생물학회지 Vol.56 No.4
Photobacterium damselae subsp. damselae (Pdd) is an important pathogen in various marine organisms and is a strong histamine producer that causes histamine fish poisoning in humans. We sequenced the genome of Pdd strain KC-Na-NB1, isolated from a narrow-ridged finless porpoise (Neophocaena asiaeorientalis). The genome of the KC-Na-NB1 strain was 4,522,546-bp long (G + C content = 40.1%), comprising two chromosomes and five plasmids. Within this genome, we found virulence-associated genes and gene clusters associated with histamine production (i.e., histidine/histamine antiporter, pyridoxal phosphate-dependent histidine decarboxylase, and histidyl-tRNA synthetase), suggesting a strong potential to cause zoonotic infections and histamine fish poisoning. This work furthers our understanding of risk factors for histamine fish poisoning caused by Pdd and provides insights into microbial diversity in cetaceans.
Measurement Level Experimental Test Result of GNSS/IMU Sensors in Commercial Smartphones
Lee, Subin,Ji, Gun-Hoon,Won, Jong-Hoon 항법시스템학회 2020 Journal of Positioning, Navigation, and Timing Vol.9 No.3
The performance of Global Navigation Satellite System (GNSS) chipset and Inertial Measurement Unit (IMU) sensors embedded in smartphones for location-based services (LBS) is limited due to the economic reasons for their mass production. Therefore, it is necessary to efficiently process the output data of the smartphone's embedded sensors in order to derive the optimum navigation values and, as a previous step, output performance of smartphone embedded sensors needs to be verified. This paper analyzes the navigation performance of such devices by processing the raw measurements data output from smartphones. For this, up-to-dated versions of smartphones provided by Samsung (Galaxy s10e) and Xiaomi (Mi 8) are used in the test experiment to compare their performances and characteristics. The GNSS and IMU data are extracted and saved by using an open market application software (Geo++ RINEX Logger & Mobile MATLAB), and then analyzed in post-processing manner. For GNSS chipset, data is extracted from static environments and verified the position, Carrier-to-Noise (C/N<sub>0</sub>), Radio Frequency Interference (RFI) performance. For IMU sensor, the validity of navigation and various location-based-services is predicted by extracting, storing and analyzing data in static and dynamic environments.
Lee, Jaehong,Shin, Sera,Kang, Subin,Lee, Sanggeun,Seo, Jungmok,Lee, Taeyoon Hindawi Limited 2015 Journal of nanomaterials Vol.2015 No.-
<P>Graphene can be effectively applied as an ultrathin barrier for fluids, gases, and atoms based on its excellent impermeability. In this work, few-layer graphene was encapsulated on silver (Ag) nanoparticles for the fabrication of highly stable surface-enhanced Raman scattering (SERS) substrates, which has strong resistance to oxidation of the Ag nanoparticles. The few-layer graphene can be successfully grown on the surface of the Ag nanoparticles through a simple heating process. To prevent the agglomeration of the Ag nanoparticles in the fabrication process, poly(methyl methacrylate) (PMMA) layers were used as a solid carbon source instead of methane (CH4) gas generally used as a carbon source for the synthesis of graphene. X-ray diffraction (XRD) spectra of the few-layer graphene-encapsulated Ag nanoparticles indicate that the few-layer graphene can protect the Ag nanoparticles from surface oxidation after intensive annealing processes in ambient conditions, giving the highly stable SERS substrates. The Raman spectra of Rhodamine 6G (R6G) deposited on the stable SERS substrates exhibit maintenance of the Raman signal intensity despite the annealing process in air. The facile approach to fabricate the few-layer graphene-encapsulated Ag nanoparticles can be effectively useful for various applications in chemical and biological sensors by providing the highly stable SERS substrates.</P>