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Abies koreana 유래 정유의 항주름 및 미백 효과
송병욱(Byeong-Wook Song),송민정(Min-Jeong Song),박미진(Mi-Jin Park),최돈하(Don-Ha Choi),이성숙(Sung-Suk Lee),김명길(Myungkil Kim),황기철(Ki-Chul Hwang),김일권(Il-Kwon Kim) 한국생명과학회 2018 생명과학회지 Vol.28 No.5
구상나무로부터 추출된 정유가 개발되어 있지만, 피부와 연관된 연구 관점에서 효능이 아직까지 밝혀지지 않았다. 본 연구의 목적은 B16F10 흑색종 세포(B16F10)와 인간 피부아세포주(HDF)에서 멜라닌과 주름 형성 상의 구상나무 추출물 효과를 알아보는데 있다. 정유는 수첨 증류법으로 추출하였고 무수 황산나트륨으로 정제 하였다. 10<SUP>-5</SUP>배의 정유농도에서, 두 세포의 생존능은 세포독성 평가에 의해 확인 되었다. B18F10의 항멜라닌 효과는 티로시나아제 억제 분석과 티로시나아제, 티로시나아제 연관 단백질 -1과 -2(TRP-1, TRP-2)의 유전자 발현 검증을 통해 이루어졌다. 정유는 알파-멜라닌세포 자극 호르몬 유도 그룹과 비교하여 티로시나아제 억제 활성이 5배, 아르부틴 유도 그룹과 비교하였을 때 30% 정도 감소되었다. 3가지 멜라닌 유래 인자들의 mRNA 수준도 각각 증가하였다. 항주름 효과를 분석하기 위해, 프로콜라겐 타입 I c 펩티드 합성(PIP) 분석과 웨스턴 블록을 수행하였다. 정유를 처리한 그룹에서 PIP가 증가되었고 콜라겐 타입 1과 기질 금속 단백질 분해 효소가 개선 되었다. 또한 정유는 60 mJ/㎠의 자외선 조건에서, 자외선-억제 콜라겐 타입 1의 증가와 기질 금속 단백질 분해 효소 생성 억제를 통해 항주름 효과를 보여줬다. 따라서 구상나무 추출물은 미백과 항주름을 위한 안전하고 효과적인 피부 제재로서 가능성을 가지고 있음을 암시한다. The essential oil from Abies koreana E.H. Wilson had been developed, however, its efficacy has not yet been studied especially in terms of skin care research. The aim of this study is to investigate the effects of Abies koreana extracts (AKE) on melanogenesis and wrinkle formation in B16F10 melanoma cells (B16F10) and human dermal fibroblast cell line (HDF). The essential oil was extracted by hydrodistillation method and purified by anhydrous sodium sulfate. At a concentration of 10<SUP>-5</SUP>-fold, viability in these cells had been defined by cytotoxicity assays. Anti-melanogenic effects on B16F10 were evaluated using tyrosinase inhibition assay, and real-time PCR for verifying gene expression of tyrosinase, tyrosinase related protein-1 and -2 (TRP-1 and -2). AKEs reduced about 5-fold of tyrosinase inhibitory activity compared to α-melanocyte-stimulating hormone (α-MSH)-induced group and about 30% reduction compared to Arbutin induced group. The mRNA levels of three melanin-related factors were increased, separately. To investigate the effects of anti-wrinkle, procollagen type I c peptide synthesis assay (PIP) and Western blot were performed. At AKE-treated group, PIP was up-regulated and the expression of collagen type 1 and matrix metalloproteinase (MMP)-1 were improved. Furthermore, AKE presented anti-wrinkle effects by increasing UVB-inhibited collagen type 1 expression, and reducing UVB-induced MMP-1 production at 60 mJ/cm² of UVB radiation. Therefore, Abies koreana extracts has potentials as a safe and an effective skin ingredient for whitening and anti-wrinkle.
조봉관,고병희,김덕호,유봉하,정승기,조동현,송병기,송일병,제등정남,Jo, Bong-Gwan,Go, Byeong-Hui,Kim, Deok-Ho,Yu, Bong-Ha,Jeong, Seung-Gi,Jo, Dong-Hyeon,Song, Byeong-Gi,Song, Il-Byeong The Society Of Sasang Constitutional Medicine 1992 사상체질의학회지 Vol.4 No.1
Skin conductance level (SCL) is used to analyze the individual differences in pathological states. The points of measurement were on the back of the second metacarpals, according to the Zhang's biological whole body medical treatment method. SCL was measured in 38 healthy men and women and in 98 patients in lung, liver, stomach, kidney, and paralysis. The classification of the physical constitution was done to them with respect to Lee's physical constitution theory. The following tendencies were observed. 1. SCL in patients group is lower than that in healthy group. 2. In healthy group, SCL in micro-positive physical constitution is higher than those of micro-negative and macro-negative physical constitution. 3. In patients group, SCL in micro-positive physical constitution is lower than those of micro-negative and macro-negative physical constitution vice versa.
Adjuvant Efficacy of mOMV Against Avian Influenza Virus Infection in Mice
Byeong-Jae Lee,Min-Suk Song,Philippe Noriel Q. Pascua,Hyeok-il Kwon,Su-Jin Park,Eun-Ha Kim,Arun Decano,Se Mi Kim,Gyo Jin Lim,Sang-Ho Lee,Kyu-Tae Chang,Sang-Hyun Kim,Young Ki Choi 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.2
Rituximab-Induced Pneumonitis on F-18 FDG PET/CT in Patient With Non-Hodgkin Lymphoma
Song, Bong-Il,Lee, Sang-Woo,Lee, Hong Je,Kang, Sungmin,Young Jeong, Shin,Seo, Ji-Hyoung,Ahn, Byeong-Cheol,Lee, Jaetae,Shin, Kyung-Min Lippincott Williams Wilkins, Inc. 2010 Clinical nuclear medicine Vol.35 No.8
Pulmonary drug toxicity is increasingly being diagnosed as a cause of acute and chronic lung disease. We report a case of drug-induced pneumonitis after R-CHOP therapy for non-Hodgkin lymphoma in which a follow-up examination F-18 FDG PET/CT showed some patchy consolidations and ground-glass opacities with diffuse FDG uptake in both lungs. Even though antibiotic management was not effective, after treatment with prednisolone the patient improved dramatically. Repeated conventional chest CT showed only minimal residual linear fibrotic opacity. After chemotherapy was changed to CHOP, complete remission was achieved without any pulmonary lesions.
Development and Preliminary Performance Evaluation of a Small Animal Dedicated SPECT System
( Byeong Il Lee ),( Jae Sung Lee ),( Joong Hyun Kim ),( Jin Su Kim ),( Su Mi Kim ),( Yong Choi ),( Tae Yong Song ),( Jin Ho Jung ),( Dong Soo Lee ),( June Key Chung ),( Myung Chul Lee ) 대한핵의학회 2004 핵의학 분자영상 Vol.38 No.5
Byeong-Deok Hong,Kyo-seok Lee,Dong-Sung Lee,Ja-Hyun Rhie,Hui-Su Bae,IL-Hwan Seo,Seung-Geun Song,Doug-Young Chung 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.5
In this experiment we investigated the influence of various anions including oxalic acid encountered as solution phase in soil on the adsorption and desorption of sulfate in Chungwon Bt soil. The effect of chloride and nitrate on the adsorption of sulfate was not significant, suggesting that sulfate was better able to compete for adsorption sites at concentrations studied, in contrast to the large reduction in the amount of chloride adsorbed in the presence of sulfate. The results of competition for sorption sites between sulfate and anion showed that the simultaneous presence of two anions in solution was effective in reduction of competing anion at a maximum value of adsorption, due to the similar adsorption mechanism for anion competition. Therefore, the variation in the buffer power of the acids will produce a change in the strength and amount of adsorption and the competitive ability.