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CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers
Giri, Shiv Kumar,Yadav, Anita,Kumar, Anil,Dev, Kapil,Gulati, Sachin,Gupta, Ranjan,Aggarwal, Neeraj,Gautam, Sanjeev Kumar Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Aim: It is well known that polycyclic aromatic hydrocarbons (PAHs) such as benzo (a) pyrene have carcinogenic properties and may cause many types of cancers in human populations. Genetic susceptibility might be due to variation in genes encoding for carcinogen metabolizing enzymes, such as cytochrome P-450 (CYP450). Our study aimed to investigate the effect of genetic polymorphisms of CYP1A1 (m1 and m2) on genetic damage in 115 coal-tar workers exposed to PAHs at their work place. Methods: Genetic polymorphisms of CYP1A1 were determined by the PCR-RFLP method. Comet and buccal micronucleus assays were used to evaluate genetic damage among 115 coal tar workers and 105 control subjects. Results: Both CYP1A1 m1 and CYP1A1 m2 heterozygous and homozygous (wt/mt+mt/mt) variants individually as well as synergistically showed significant association (P<0.05) with genetic damage as measured by tail moment (TM) and buccal micronuclei (BMN) frequencies in control and exposed subjects. Conclusion: In our study we found significant association of CYP1A1 m1 and m2 heterozygous (wt/mt)+homozygous (mt/mt) variants with genetic damage suggesting that these polymorphisms may modulate the effects of PAH exposure in occupational settings.
Purely Extending Modules and Their Generalizations
Shiv Kumar,Ashok Ji Gupta 경북대학교 자연과학대학 수학과 2023 Kyungpook mathematical journal Vol.63 No.1
A purely extending module is a generalization of an extending module. In this paper, we study several properties of purely extending modules and introduce the notion of purely essentially Baer modules. A module M is said to be a purely essentially Baer if the right annihilator in M of any left ideal of the endomorphism ring of M is essential in a pure submodule of M. We study some properties of purely essentially Baer modules and characterize von Neumann regular rings in terms of purely essentially Baer modules.
Sameer Gupta,Sudeep Garg,Vijay Kumar,Arun Chaturvedi,Sanjeev Misra,Naseem Akhtar,Shiv Rajan,Jatinder Kaur,Manikandan Lakshmanan,Kavitha Jain 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.4
Backgrounds/Aims: Transglutaminase 2 (TG2) is known to be an important mediator of inflammation induced carcinogenesis pathway. Chronic inflammation is the most important causative factor in Gallbladder cancer (GBC) carcinogenesis. We analyzed the expression of TG2 in GBC and its role as potential prognostic marker, first of its kind study. Methods: We analyzed TG2 expression in 100 cases of GBC and 28 cases of non-cancer gallbladder specimen (calculus cholecystitis). We studied TG2 expression in GBC in comparison to control group and evaluated its role as a potential prognostic marker. Results: TG2 score (1-9) was calculated by multiplying percentage cytoplasmic expression (P) with intensity of expression (I) in tumor cells. Positive TG-2 expression was observed in 62% of GBC patients compared to only 21% (n=6) in control group (p=0.001). In curative resection subgroup (n=54), TG2 positive patients showed shorter disease free survival rate (p=0.04) and higher rate of recurrence (p=0.03) compared to TG2 negative patients. TG2 positive expression was observed in 15/16 of patients with recurrent disease. In palliative treatment subgroup, patients with strong TG2 positive expression had poorer disease specific survival (p=0.01) as compared to weakly positive group. On multivariate analysis, lymph node status (p=0.03) and TG2 expression (p=0.037), were found to be significant predictor of recurrence and eventual survival. Conclusions: Positive TG2 expression was related to higher recurrence rates post curative surgery, shorter disease free and overall survival and ultimately portended poor prognosis. It may be helpful in better prognostication and tailoring therapeutic approach for better management of GBC.
Umrao, Sima,Gupta, Tejendra K.,Kumar, Shiv,Singh, Vijay K.,Sultania, Manish K.,Jung, Jung Hwan,Oh, Il-Kwon,Srivastava, Anchal American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.35
<P>The electromagnetic interference (EMI) shielding of reduced graphene oxide (MRG), B-doped MRG (BMRG), N-doped MRG (N-MRG), and B-N co-doped MRG (B-N-MRG) have been studied in the Ku-band frequency range (12.8-18 GHz). We have developed a green, fast, and cost-effective microwave assisted route for synthesis of doped MRG. B-N-MRG shows high electrical conductivity in comparison to MRG, B-MRG and N-MRG, which results better electromagnetic interference (EMI) shielding ability. The co-doping of B and N significantly enhances the electrical conductivity of MRG from 21.4 to 124.4 Sm-1 because N introduces electrons and B provides holes in the system and may form a nanojunction inside the material. Their temperature-dependent electrical conductivity follows 2D-variable range hopping (2D-VRH) and Efros-Shldovskii-VRH (ES-VRH) conduction model in a low temperature range (T < 50 K). The spatial configuration of MRG after doping of B and N enhances the space charge polarization, natural resonance, dielectric polarization, and trapping of EM waves by internal reflection leading to a high EMI shielding of -42 dB (-99.99% attenuation) compared to undoped MR.G (-28 dB) at a critical thickness of 1.2 mm. Results suggest that the B-N-MRG has great potential as a candidate for a new type of EMI shielding material useful in aircraft, defense industries, communication systems, and stealth technology.</P>
NONDIFFERENTIABLE SECOND-ORDER MINIMAX MIXED INTEGER SYMMETRIC DUALITY
Gulati, Tilak Raj,Gupta, Shiv Kumar Korean Mathematical Society 2011 대한수학회지 Vol.48 No.1
In this paper, a pair of Wolfe type nondifferentiable sec-ond order symmetric minimax mixed integer dual problems is formu-lated. Symmetric and self-duality theorems are established under $\eta_1$-bonvexity/$\eta_2$-boncavity assumptions. Several known results are obtained as special cases. Examples of such primal and dual problems are also given.
NONDIFFERENTIABLE SECOND-ORDER MINIMAX MIXED INTEGER SYMMETRIC DUALITY
Tilak Raj Gulati,Shiv Kumar Gupta 대한수학회 2011 대한수학회지 Vol.48 No.1
In this paper, a pair of Wolfe type nondifferentiable second order symmetric minimax mixed integer dual problems is formulated. Symmetric and self-duality theorems are established under η1/η2-boncavity assumptions. Several known results are obtained as special cases. Examples of such primal and dual problems are also given.