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The Radical Scavenging Effects of Stilbene Glucosides from Polygonum multiflorum
Ryu, Geon-Seek,Ju, Jeung-Hoon,Park, Yong-Ju,Ryu, Shi-Yong,Choi, Byoung-Wook,Lee, Bong-Ho The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-Ο-$\beta$-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity ($IC_{50}$, 40 $\mu$M), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity ($IC_{50}$, 0.38 $\mu$M).
Ryu, Jae-Ha,Ryu, Shi-Yong,Han, Yong-Nam,Han, Byung-Hoon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.1
A new celastraceae alkaloid, euojaponine C has been isolated from the methanol extract of the root bark of Euonymus japonica. With the relative stereochemistry of euojaponine C established by NOESY data, the absolute stereochemistry has been determined by circular dichroism (CD) exciton chirality method. The CD of the 2, 5-bis-phenyl benzoate of triacetonide derived from the LiAlH$_{4}$, hydrolysate, euonyminol shows that the configuration of C-2 and C-5 are both R.
Antitumor activity of Trichosanthes kirilowii
Ryu, Shi-Yong,Lee, Seung-Ho,Lee, Sang-Un,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The activity fractionation upon the MeOH extract of the root of trichosanthes kirilowii led to the isolation of eight cucurbitane tritepense namely cucurbitacin .betha. (I), isocucurbitacin .betha.(II), cucurbitacin D(III), isocucurbitacin D(IV), 3-epi-isocucurbitacin .betha(V), dihydrocucurbitain .betha. (VI), dihydroisocucurgbitachin .betha. (VII) and dihydrocucurbitacin E (VIII), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, Sk-OV-3, Sk-MEL-2, XF-498 and HCT 15, with an exceptionally high potency.
Antitumor Activity of Psorelea corylifolia
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+) bakuchio 1 as an activ eprinciple of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, i. e. the A549, SK-OV-3, SK-MEL-2, XF-498 and HCT15. The synthesized 2, 3-epoxide of (+)-bakuchiol 3 showed the similar activity as the (+) bakuchiol 1, whereas the other oxidation derivatives 4 and 5 including the acetyl (+) bakuchiol 2 showed a decreased activity.
Antiviral Triterpenes from Prunella vulgaris
Ryu, Shi-Yong,Lee, Chong-Kyo,Lee, Chong-Ock,Kim, Hae-Soo,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.3
Two triterpenes 1 and 2 with antiviral activity against Herpes simplex virus type 1 in vitro were isolated from Prunella vulgaris. Each compound caused a significant reduction in viral cytopathic effect when vero cells were exposed to them for 72 hours after viral challenge. They were identified as betulinic acid (1) and $2\alpha, 3\alpha$-dihydroxyurs-12-en-28-oic acid(2) on the basis of their spectroscopic properties. The antiviral activity of them was estimated as $EC_{50}=30\;\mu$g/ml(1) and $8\;\mu$g/ml(2), respectively by plaque reduction assay.
Antitumor Activity of some Phenolic Components in Plants
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Lee, Seung-Ho,Ahn, Jong-Woong,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.1
The activity-guided fractionation of some medicinal plants led to yield five kinds of natural stilbene compounds namely 3, 5-dihydroxy-4'-methoxystillbene(I), rhapontigenin(II), reveratrol(III), rhaponticin(IV) and piceid(V) and two common flavonoids, apigenin(VI) and luteolin(VII) as active principles of the antitumor property, in vitro, against five kinds of human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15.
Ryu, Shi Yong,Oak, Min Ho,Kim, Kyeong Man 전남대학교 약품개발연구소 2000 약품개발연구지 Vol.9 No.1
Yomogin (1). an eudesmane sesquiterpene isolated from Artemisia princeps, was tested for the effects on the degranulation process of cultured mast cells and on the nitric oxide production in LPS-activated marine macrophages. It demonstrated a significant inhibition on the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner (IC_(50) value, 50 μM) and also exhibited a potent inhibition on the nitric oxide production from the activated RAW264.7 cells (IC_(50) value, 3 μM).