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Nanotechnology in reproductive medicine: Opportunities for clinical translation
Shandilya, Ruchita,Pathak, Neelam,Lohiya, Nirmal Kumar,Sharma, Radhey Shyam,Mishra, Pradyumna Kumar The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.4
In recent years, nanotechnology has revolutionized global healthcare and has been predicted to exert a remarkable effect on clinical medicine. In this context, the clinical use of nanomaterials for cancer diagnosis, fertility preservation, and the management of infertility and other pathologies linked to pubertal development, menopause, sexually transmitted infections, and HIV (human immunodeficiency virus) has substantial promise to fill the existing lacunae in reproductive healthcare. Of late, a number of clinical trials involving the use of nanoparticles for the early detection of reproductive tract infections and cancers, targeted drug delivery, and cellular therapeutics have been conducted. However, most of these trials of nanoengineering are still at a nascent stage, and better synergy between pharmaceutics, chemistry, and cutting-edge molecular sciences is needed for effective translation of these interventions from bench to bedside. To bridge the gap between translational outcome and product development, strategic partnerships with the insight and ability to anticipate challenges, as well as an indepth understanding of the molecular pathways involved, are highly essential. Such amalgamations would overcome the regulatory gauntlet and technical hurdles, thereby facilitating the effective clinical translation of these nano-based tools and technologies. The present review comprehensively focuses on emerging applications of nanotechnology, which holds enormous promise for improved therapeutics and early diagnosis of various human reproductive tract diseases and conditions.
Apoorva Shandilya,Geetanjali Mishra,Omkar 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.3
Natural injuries and their causes have recently garnered attention amongst researchers, however the effects of these injuries on life history traits are still sparsely investigated. In the few studies that have been conducted injuries are known to have a debilitating effect on male virility and reproductive performance. Thus the effect of leg injuries in males on mating behaviour and reproductive output in the ladybird beetle, Menochilus sexmaculatus was investigated. This is the first study on the effect of injury on any life history trait in Coccinellidae. The legs of the male were amputated at three different joints on the same side and opposite sides for one leg or two legs. These amputated males were paired with uninjured females and the mating behaviour and subsequent reproductive output was observed. Time to commence mating, latent period and mating duration in impaired males were observed and were all found to be higher than that of uninjured males. Fecundity and percent egg viability were reduced in all impaired male pairs. Males with physical disability were found to copulate for an extended duration, perhaps to ensure maximum paternity.
Shashank Shandilya,Charu Madhu,Vijay Kumar 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.3
The increasing demand for faster and energy efficient electronics has forced the researchers to develop more power and performance efficient integrated circuits. For this purpose, the overall size of the transistor needs to be scaled down to its very limit. Transistor scaling and performance are not only limited to overall transistor design but also to the material of the channel that is being used. In order to make a performance efficient transistor, not only is a new transistor design needed but replacement of conventional channel material i.e., silicon needs to be done. In this work, a 2-D Numerical simulation model of nanowire FET with GAA technology was carried out at 22 nm gate length using an open-source nanoscale simulation tool MUGFET. Then a study of the performance parameters of this NW-GAAFET with Silicon and Group III-V compound semiconductor channel materials and High-k gate oxides has been performed. The electrical performance parameters, drain induced barrier lowering (DIBL), subthreshold swing (SS), and on/off current ratio (Ion/Ioff) are extracted and validated through comparative analysis with previous high performance GAA nanowire FETs.
Anita Sudhaik,Pankaj Raizada,Pooja Shandilya,정대용,임지호,Pardeep Singh 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
Graphitic carbon nitride (g-C3N4) as a fascinating visible light active semiconductor photocatalyst has medium band gap, non-toxic nature, stable chemical structure and high thermal stability. Recently, intensive researches are focused on photocatalytic activity of g-C3N4 for wastewater treatment. This review demonstrates latest progress in fabrication of graphitic carbon nitride C3N4 incorporated nanocomposite to explore photocatalytic ability for water purification. The g-C3N4-based nanocomposites were categorized as g-C3N4 metal-free nanocomposite, noble metals/g-C3N4 heterojunction, non-metal doped g-C3N4, transition and post transition metal based g-C3N4 nanocomposite. Apart from fabrication methods, we emphasized on elaborating the mechanism of activity enhancement during photocatalytic process.