실제 작동 중 엔진 동특성 파악 및 부품 강성 변화에 따른 영향 분석

강성호(Seongho Kang),박한솔(Hansol Park),김성준(Seoungjoon Kim),주형준(Hyungjun Ju),강연준(Yeon June Kang) 한국소음진동공학회 2019 한국소음진동공학회 학술대회논문집 Vol.2019 No.2

Silk Amino Acids Improve Physical Stamina and Male Reproductive Function of Mice

Shin, Sunhee,Yeon, Seongho,Park, Dongsun,Oh, Jiyoung,Kang, Hyomin,Kim, Sunghyun,Joo, Seong Soo,Lim, Woo-Taek,Lee, Jeong-Yong,Choi, Kyung-Chul,Kim, Ki Yon,Kim, Seung Up,Kim, Jong-Choon,Kim, Yun-Bae Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.2

<P>The effects of a silk amino acid (SAA) preparation on the physical stamina and male reproductive function of mice were investigated. Eight-week-old male ICR mice (29—31 g) were orally administered SAA (50, 160 or 500 mg/kg) for 44 d during 30-min daily swimming exercise. The mice were subjected to a weight-loaded (5% of body weight) forced swimming on the 14th, 28th and 42nd day to determine maximum swimming time, and after a 2-d recovery period (treated with SAA without swimming exercise), parameters related to fatigue and reproductive function were analyzed from blood, muscles and reproductive organs. Repeated swimming exercise increased the maximum swimming time to some extent, in spite of a marked reduction in body weight gain, and SAA further enhanced the stamina in a dose-dependent manner. Forced swimming exercises increased blood parameters of tissue injury, but depleted blood glucose and tissue glycogen, which were substantially prevented by SAA treatment. In addition, SAA significantly reduced the muscular thiobarbituric acid-reactive substances and blood corticosterone content increased by forced swimming. Swimming exercise decreased the blood testosterone level, which was recovered by SAA, leading to enhanced sperm counts. These combined results indicate that SAA not only enhances physical stamina by minimizing damage to tissues, including muscles, as well as preventing energy depletion caused by swimming stress, but also improves male reproductive function by increasing testosterone and sperm counts.</P>

[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study

Jeon, So Yeon,Seo, Seongho,Lee, Jae Sung,Choi, Soo-Hee,Lee, Do-Hyeong,Jung, Ye-Ha,Song, Man-Kyu,Lee, Kyung-Jun,Kim, Yong Chul,Kwon, Hyun Woo,Im, Hyung-Jun,Lee, Dong Soo,Cheon, Gi Jeong,Kang, Do-Hyung Williams & Wilkins Co 2017 Medicine Vol.96 No.1

ABSTRACT: Complex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case–control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [C]-(R)-PK11195. [C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30–55 years) and 12 control subjects (30–52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based graphical analysis. The DVR of [C]-(R)-PK11195 in the caudate nucleus (t(21) = −3.209, P = 0.004), putamen (t(21) = −2.492, P = 0.022), nucleus accumbens (t(21) = −2.218, P = 0.040), and thalamus (t(21) = −2.395, P = 0.026) were significantly higher in CRPS patients than in healthy controls. Those of globus pallidus (t(21) = −2.045, P = 0.054) tended to be higher in CRPS patients than in healthy controls. In patients with CRPS, there was a positive correlation between the DVR of [C]-(R)-PK11195 in the caudate nucleus and the pain score, the visual analog scale (r = 0.661, P = 0.026, R = 0.408) and affective subscales of McGill Pain Questionnaire (r = 0.604, P = 0.049, R = 0.364). We demonstrated that neuroinflammation of CRPS patients in basal ganglia. Our results suggest that microglial pathology can be an important pathophysiology of CRPS. Association between the level of caudate nucleus and pain severity indicated that neuroinflammation in this region might play a key role. These results may be essential for developing effective medical treatments.

임베디드 리눅스 기반 AMI 기기의 효율적인 원격 펌웨어 업데이트 방법

박민하(Minha Park),주성호(Seongho Ju),송석진(Seokjin Song),최주연(Ju-yeon Choi) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.7

Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent ¹⁸ F-FPTP

Kim, Ji Who,Seo, Seongho,Kim, Hyeon Sik,Kim, Dong-Yeon,Lee, Ho-Young,Kang, Keon Wook,Lee, Dong Soo,Bom, Hee-Seung,Min, Jung-Joon,Lee, Jae Sung Springer Japan 2017 Annals of nuclear medicine Vol.31 No.6

<P><B>Objective</B></P><P>(<SUP>18</SUP>F-fluoropentyl)triphenylphosphonium salt (<SUP>18</SUP>F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of <SUP>18</SUP>F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken.</P><P><B>Methods</B></P><P><SUP>18</SUP>F-FPTP dynamic PET (18 min) and CT images were acquired from rats with myocardial infarction (MI) (<I>n</I> = 12). Regions of interest (ROIs) were on the left ventricle, normal myocardium, and MI region. Two-compartment (<I>K</I><SUB>1</SUB> and <I>k</I><SUB>2</SUB>; 2C2P) and three-compartment (<I>K</I><SUB>1</SUB>–<I>k</I><SUB>3</SUB>; 3C3P) models with irreversible uptake were compared for goodness-of-fit. Partial volume and spillover correction terms (<I>V</I><SUB><I>a</I></SUB> and <I>α</I> = 1 − <I>V</I><SUB><I>a</I></SUB>) were also incorporated. LLS and BFM were applied to ROI- and voxel-based kinetic parameter estimations. Results were compared with the standard ROI-based nonlinear least-squares (NLS) results of the corresponding compartment model. A simulation explored statistical properties of the estimation methods.</P><P><B>Results</B></P><P>The 2C2P model was most suitable for describing <SUP>18</SUP>F-FPTP kinetics. Average <I>K</I><SUB>1</SUB>, <I>k</I><SUB>2</SUB>, and <I>V</I><SUB><I>a</I></SUB> values were, respectively, 6.8 (ml/min/g), 1.1 (min<SUP>−1</SUP>), and 0.44 in normal myocardium and 1.4 (ml/min/g), 1.1 (min<SUP>−1</SUP>), and 0.32, in MI tissue. Ten minutes of data was sufficient for the estimation. LLS and BFM estimations correlated well with NLS values for the ROI level (<I>K</I><SUB>1</SUB>: <I>y</I> = 1.06<I>x</I> + 0.13, <I>r</I><SUP><I>2</I></SUP> = 0.96 and <I>y</I> = 1.13<I>x</I> + 0.08, <I>r</I><SUP><I>2</I></SUP> = 0.97) and voxel level (<I>K</I><SUB>1</SUB>: <I>y</I> = 1.22<I>x</I> − 0.30, <I>r</I><SUP><I>2</I></SUP> = 0.90 and <I>y</I> = 1.26<I>x</I> + 0.00, <I>r</I><SUP><I>2</I></SUP> = 0.92). Regional distribution of kinetic parametric images (<I>αK</I><SUB>1</SUB>, <I>K</I><SUB>1</SUB>, <I>k</I><SUB>2</SUB>, <I>V</I><SUB>a</SUB>) was physiologically relevant. LLS and BFM showed more robust characteristics than NLS in the simulation.</P><P><B>Conclusions</B></P><P>Fast kinetics and highly specific uptake of <SUP>18</SUP>F-FPTP by myocardium enabled quantitative analysis with the 2C2P model using only the initial 10 min of data. LLS and BFM were feasible for estimating voxel-wise parameters. These two methods will be useful for quantitative evaluation of <SUP>18</SUP>F-FPTP distribution in myocardium and in further studies with different conditions, disease models, and species.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s12149-017-1171-6) contains supplementary material, which is available to authorized users.</P>

Stamina-Enhancing Effects of Silk Amino Acid Preparations in Mice

Sunhee Shin,Dongsun Park,Seongho Yeon,Jeong Hee Jeon,Tae Kyun Kim,Seong Soo Joo,Woo-Taek Lim,Jeong-Yong Lee,Yun-Bae Kim 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.2

Effects of silk amino acid preparations (SAA-1, SAA-2 and SAA-3) on stamina and male reproductive functions were investigated. Eight-week-old male ICR mice (30-33 g) were orally administered with the preparations (800 ㎎/㎏) for 30 days in resting condition or during 30-min daily swimming exercise. The mice were subjected to a weight-loaded (5% of body weight) forced swimming on 14th and 28th days to determine maximum swimming time, and after 2-day recovery period, parameters related to stamina and reproductive functions were analyzed from blood, muscles and testes. Repeated swimming performance increased the maximum swimming time to some extent, and the 3 SAA preparations further enhanced the stamina, in spite of reduced body weight gain in SAA-1- and SAA-3-treated mice. SAA-1 and SAA-2 exhibited long-term stamina-enhancing effects, while SAA-3 exerted an early marked activity on day 14. Swimming exercise increased blood parameters of muscular damage, liver injury, energy depletion and nitrogen accumulation, which were substantially prevented by SAA preparations, especially SAA-1 and SAA-2. All the SAA preparations increased testes weight, and SAA-3 and SAA-2 increased testosterone concentration, leading to enhanced sperm counts in resting and exercised mice, respectively. Taken together, it is suggested that all 3 SAA preparations possess an energy-boosting effect, although they exhibited different activities on male reproductive function.

위젯서비스의 Application Open Ecosystem 구축 연구

김동훈(Donghoon Kim),배정일(Jungil Bae),연승호(Seongho Yeon) 한국IT서비스학회 2009 한국IT서비스학회 학술대회 논문집 Vol.2009 No.1

기존의 컨텐츠 전달 방법은 인터넷 서핑을 통한 획득의 개념으로 이루어졌다고 볼수 있다. IT 서비스와 유무선 인터넷 기술의 비약적인 발전에 따라 사용자는 더 이상 컨텐츠의 획득을 위해 직접 찾아 나서지 않아도 몇가지 설정만을 통해 컨텐츠가 나를 찾아오는 시대가 되었다. 이런 형태의 서비스들 중에서 최근의 단말 발전경향과 더불어 위젯 서비스가 급격히 발전하였다. 더불어 컨텐츠의 소비자이던 일반인들이 약간의 개발을 통해 직접 컨텐츠의 생산자, 배포자가 될 수 있는 개발환경이 최근에는 큰 이슈가 되고 있다. 기존의 서비스 사업자들은 직접 컨텐츠를 전달하는 어플리케이션을 개발하여 공급하였지만, Open API 를 통해 외부의 개발자들이 직접 필요한 어플리케이션을 개발하여 공유하고 수익을 배분하는 형태의 사업이 바로 Application Open Ecosystem 이라고 할 수 있다. 본 논문에서는 위젯 서비스의 Open cosystem 을 구축하는 방법에 대한 연구를 정리하여 소개하고자 한다.

Multi-atlas cardiac PET segmentation

Kim, Sally Ji Who,Seo, Seongho,Kim, Hyeon Sik,Kim, Dong-Yeon,Kang, Keon Wook,Min, Jung-Joon,Lee, Jae Sung Elsevier 2019 Physica Medica Vol.58 No.-

<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>We propose a multi-atlas based segmentation method for cardiac PET and SPECT images to deal with the high variability of tracer uptake characteristics in myocardium. In addition, we verify its performance by comparing it to the manual segmentation and single-atlas based approach, using dynamic myocardial PET.</P> <P><B>Methods</B></P> <P>Twelve left coronary artery ligated SD rats underwent ([<SUP>18</SUP>F]fluoropentyl) triphenylphosphonium salt PET/CT scans. Atlas-based segmentation is based on the spatial normalized template with pre-defined region-of-interest (ROI) for each anatomical or functional structure. To generate multiple left ventricular (LV) atlases, each LV image was segmented manually and divided into angular segments. The segmentation methods performances were compared in regional count information using leave-one-out cross-validation. Additionally, the polar-maps of kinetic parameters were estimated.</P> <P><B>Results</B></P> <P>In all images, the highest <I>r</I> <SUP>2</SUP> template yielded the lowest root-mean-square error (RMSE) between the source image and the best-matching templates ranged between 0.91–0.97 and 0.06–0.11, respectively. The single-atlas and multi-atlas based ROIs yielded remarkably different perfusion distributions: only the multi-atlas based segmentation showed equivalent high correlation results (<I>r</I> <SUP>2</SUP> = 0.92) with the manual segmentation compared with the single-atlas based (<I>r</I> <SUP>2</SUP> = 0.88). The high perfusion value underestimation was remarkable in single-atlas based segmentation.</P> <P><B>Conclusions</B></P> <P>The main advantage of the proposed multi-atlas based cardiac segmentation method is that it does not require any prior information on the tracer distribution to be incorporated into the image segmentation algorithms. Therefore, the same procedure suggested here is applicable to any other cardiac PET or SPECT imaging agents without modification.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A multi-atlas based segmentation method for cardiac PET and SPECT images. </LI> <LI> Remarkably different perfusion between single-atlas and multi-atlas based ROIs. </LI> <LI> High correlation results between multi-atlas based and manual segmentations. </LI> </UL> </P>

Tau positron emission tomography using [¹⁸F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease

Kang, Jae Myeong,Lee, Sang-Yoon,Seo, Seongho,Jeong, Hye Jin,Woo, Sung-Ho,Lee, Hyon,Lee, Yeong-Bae,Yeon, Byeong Kil,Shin, Dong Hoon,Park, Kee Hyung,Kang, Hyejin,Okamura, Nobuyuki,Furumoto, Shozo,Yanai, Elsevier 2017 NEUROBIOLOGY OF AGING Vol. No.

<P><B>Abstract</B></P> <P>This study aims to evaluate the clinical validity of [<SUP>18</SUP>F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [<SUP>18</SUP>F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed. In patients with AD dementia, [<SUP>18</SUP>F]THK5351 retention was greater in most association cortices as well as the limbic area compared to NC or aMCI participants. Patients with aMCI also showed higher THK5351 retention in those areas compared to NC. [<SUP>18</SUP>F]THK5351 retention significantly correlated with neuropsychological test results. Negative correlations between [<SUP>18</SUP>F]THK5351 and [<SUP>18</SUP>F] fluorodeoxyglucose were observed in AD dementia and aMCI groups. Mirror images of [<SUP>18</SUP>F]THK5351 retention and glucose hypometabolism in [<SUP>18</SUP>F] fluorodeoxyglucose were noticeable in the focal variants of AD. [<SUP>18</SUP>F]THK5351 PET reflects disease severity and symptoms in AD. Our results suggest [<SUP>18</SUP>F]THK5351 is reflective of tau-related AD pathology.</P>

Effects of Red Ginseng Powder and Silk Peptide on Hypercholesterolemia and Atherosclerosis in Rabbits

Tae Myoung Kim,Jae Myun Ryu,Im Kwon Seo,Kyoung Mi Lee,Seongho Yeon,Shinjung Kang,Seok-Yeon Hwang,Yun-Bae Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1

The purpose of this study was to confirm the combinational effect of red ginseng powder (RGP) and silk peptide (SP) on hypercholesterolemia and atherosclerosis in rabbits. Male New Zealand White rabbits were fed only high-cholesterol diet (HCD) containing 0.5% cholesterol and 1% corn oil for 2 weeks, and then RGP (3%), SP (1% or 3%) or their combinations were added to a diet containing 0.25% cholesterol and 1% corn oil for additional 8 weeks. Blood total cholesterol and low-density lipoproteins (LDL) were greatly increased by 2-week feeding HCD to 13-15 folds of control, in contrast to the reduction of highdensity lipoproteins (HDL) to a half level. Additional 8-week feeding HCD caused thick atheromatous plaques, covering 65.8-67.3% of the aortic wall, and hepatocytic lipid peroxidation, leading to vacuolar and fatty degeneration. Such a hypercholesterolemia was significantly reduced by addition of RGP, in comparison with a mild effect of SP. In addition, HCD-induced decrease in HDL and increase in triglycerides were reversed by RGP and SP. Moreover, the atheroma area on the aortic wall as well as hepatocytic lipid peroxidation and degeneration were markedly attenuated by RGP. Especially, the effects of RGP on blood lipid profiles, atheroma formation and hepatocytic damage were potentiated by the combination of SP. The results suggest that RGP improves hypercholestarolemia and ensuing atherosclerosis, probably by both controlling lipid metabolism and reducing free radical reactions, which is synergistically enhanced by SP.