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Raman Gupta,Monika Gupta,Satya Paul,Rajive Gupta 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
A simple and efficient method has been developed for Knoevenagel condensation between aldehydes or ketones and active methylene group by stirring in methylene chloride at 60 oC under heterogeneous conditions using silica supported ammonium acetate. The products are obtained in excellent yields and are in a state of high purity. The structures of the products were confirmed by IR, 1H NMR and mass spectral data and comparison with authentic samples available commercially.
Gupta, Raman,Gupta, Monika,Paul, Satya,Gupta, Rajive Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
A simple and efficient method has been developed for Knoevenagel condensation between aldehydes or ketones and active methylene group by stirring in methylene chloride at 60 ${^{\circ}C}$ under heterogeneous conditions using silica supported ammonium acetate. The products are obtained in excellent yields and are in a state of high purity. The structures of the products were confirmed by IR, $^1H$ NMR and mass spectral data and comparison with authentic samples available commercially.
( Rodes Laetitia ),( Afshan Khan ),( Arghya Paul ),( Michael Coussa Charley ),( Daniel Marinescu ),( Catherine Tomaro Duchesneau ),( Wei Shao ),( Imen Kahouli ),( Satya Prakash ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.4
Gut-derived lipopolysaccharides (LPS) are critical to the development and progression of chronic low-grade inflammation and metabolic diseases. In this study, the effects of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharide and inflammatory cytokine concentrations were evaluated using a human colonic microbiota model. Lactobacillus reuteri, L. rhamnosus, L. plantarum, Bifidobacterium animalis, B. bifidum, B. longum, and B. longum subsp. infantis were identified from the literature for their anti-inflammatory potential. Each bacterial culture was administered daily to a human colonic microbiota model during 14 days. Colonic lipopolysaccharides, and Gram-positive and negative bacteria were quantified. RAW 264.7 macrophage cells were stimulated with supernatant from the human colonic microbiota model. Concentrations of TNF-α, IL-1β, and IL-4 cytokines were measured. Lipopolysaccharide concentrations were significantly reduced with the administration of B. bifidum (-46.45 ± 5.65%), L. rhamnosus (-30.40 ± 5.08%), B. longum (-42.50 ± 1.28%), and B. longum subsp. infantis (-68.85 ± 5.32%) (p < 0.05). Cell counts of Gram-negative and positive bacteria were distinctly affected by the probiotic administered. There was a probiotic strain-specific effect on immunomodulatory responses of RAW 264.7 macrophage cells. B. longum subsp. infantis demonstrated higher capacities to reduce TNF-α concentrations (-69.41 ± 2.78%; p < 0.05) and to increase IL-4 concentrations (+16.50 ± 0.59%; p < 0.05). Colonic lipopolysaccharides were significantly correlated with TNF-α and IL-1β concentrations (p < 0.05). These findings suggest that specific probiotic bacteria, such as B. longum subsp. infantis, might decrease colonic lipopolysaccharide concentrations, which might reduce the proinflammatory tone. This study has noteworthy applications in the field of biotherapeutics for the prevention and/or treatment of inflammatory and metabolic diseases.
Rajive Gupta,Satinder K. Juneja,Monika Gupta,Satya Paul 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.12
A solvent-free procedure is developed for the regeneration of carbonyl compounds from aldoximes or ketoximes by grinding at room temperature and from hydrazone, phenylhydrazone or semicarbazone derivatives under microwave irradiation using dioxane-dibromide/SiO2. Products are obtained in excellent yields and are in a state of high purity.
Genetic Trend for Growth in a Closed Indian Herd of Landrace × Desi Crossbreds
Gaur, G.K.,Ahlawat, S.P.S.,Chhabra, A.K.,Paul, Satya Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.4
This study has objectives of to estimate the genetic and phenotypic trend for growth in a closed herd of Landrace $\times$ desi crossbreds. The possibility of early selection of boars was also investigated in order to reduce generation interval and thus, to enhance response per year in selection programmes. The data originated from Livestock Production Research (Pigs), Indian Veterinary Research Institute (IVRI), Izatnagar (UP), India - a unit of All India Coordinated research Project on Pigs (AICRP on Pigs). Data consisted of 891 crossbred piglets, progeny of 29 boars. The piglets were born in 132 parities of 72 sows between 8 years from 1987 to 1994. Records on weight at birth, at 2 weeks interval upto 8 weeks of age (Wl, W2, ${\cdots}\;{\cdots}$ W8) and at 16th week (W16) were used in this investigation. BLLTP estimates of the sires were computed. Breeding value of each sire was estimated as twice of sire and sire group solutions. Phenotypic trend was estimated as regression of weight performance on year. Genetic trend was computed by estimating regression of breeding value of sires on time. Average body weights ranged from 0.92 kg (W1) to 18.95 kg (W16) and showed a continuous increase over age. Heritabilities of the weight at 4th and 6th week were medium (0.29 and 0.14). Rest of the weights were highly heritable. The product moment and rank, both correlations were high between breeding value for W6 and W16 (0.68 and 0.70). This shows that sire selection for W6 can be successfully implemented in order to achieve sufficient genetic improvement in growth. Phenotypic trend was positive at all ages. The phenotypic regression coefficient ranged from 0.02 kg at birth to 0.40 kg at 16 weeks. Genetic trend was also positive. The regression coefficients of average breeding value of sires on time showed a range of 1.471 kg (0.021 to 1.492 kg) for different weights. These coefficients were significant and higher than their corresponding phenotypic regression coefficient.