A new high milling and white grain wheat variety, “Joongmo2008” with moderate to pre-harvest sprouting and good bread quality

Chon-Sik Kang,Kyeong-Hoon Kim,Sang-Hyun Shin,Young-Keun Chenog,Hag-Sin Kim,Hye-Jung Kang,Kyong-Ho Kim,Jong-Chul Park,Jong-Nae Hyun,Kee-Jong Kim,Chul Soo Park 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

“Joongmo2008”, a winter wheat (Triticum aestivum L.) cultivar was developed by the National Institute of Crop Science, RDA. It is an awned, semi-dwarf and hard winter wheat. The heading and maturing date of “Joongmo2008” were similar to “Keumkang”. Culm and spike length of “Joongmo2008” were 87 cm and 8.6 cm. It had similar test weight (800g/L) and higher 1,000-grain weight (46.7g) than “Keumkang”. It showed resistance to winter hardiness and moderate to pre-harvest sprouting, which lower rate of pre-harvest sprouting (9.8%) than “Keumkang”. “Joongmo2008” had higher flour yield (73.5%) and higher ash content (0.49%) than “Keumkang”. It showed similar lightness (90.01) of flour color than “Keumkang”. It showed higher protein content (16.4%), gluten content (13.4%), SDS-sedimentation volume(59㎖) and mixing time of mixograph than “Keumkang”. “Joongmo2008” had lower amylose contetn (24.5%) and higher viscosity (153BU) than “Keumkang”. It showed same compositions in HMW-GS compositions(5+10) and Puroindolines composition compared to “Keumkang”. “Joongmo2008” showed lower firmness (0.74N) of and higher bread volume of baked pan-bread to “Keumkang”. Average yield of “Joongmo2008” in the regional adaptation yield trial was 4.54 ton/ha in upland and 3.67 ton/ha in paddy field. “Joongmo2008” would be suitable for the area above -10℃ of daily minimum temperature in January in Korean peninsula.

Improvement of Liver Fibrosis after Long-Term Antiviral Therapy Assessed by Fibroscan in Chronic Hepatitis B Patients With Advanced Fibrosis :

Chon, Young Eun,Park, Jun Yong,Myoung, Sung-Min,Jung, Kyu Sik,Kim, Beom Kyung,Kim, Seung Up,Kim, Do Young,Ahn, Sang Hoon,Han, Kwang-Hyub American College of Gastroenterology 2017 The American journal of gastroenterology Vol.112 No.6

<P>CONCLUSIONS: In CHB patients with advanced fibrosis receiving antiviral treatment, annual LS measurement revealed that fibrosis improvement slows but continues during treatment. Low LS value (< 12.0 kPa) at baseline was a significant predictor for 5-year fibrosis improvement.</P>

Recombinant Interferon-Beta-1α Plus Ribavirin for the Treatment of Chronic HCV Infection: A Prospective, Randomized, Comparative Pilot Study

( Sang Hoon Ahn ),( Hyun Woong Lee ),( Yong Soo Kim ),( Ja Kyung Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Young Myoung Moon ) 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.1

Background/Aims: Interferon beta (IFN-β) has been shown to have antiviral activity, and thus could be useful in treating viral infections. Therefore, we compared the efficacy and safety of recombinant IFN-β (IFN-β-1a) plus oral ribavirin versus interferon alpha (IFN-α) plus ribavirin therapy for the treatment of chronic hepatitis C (HCV). Methods: Twenty treatment-naive patients were randomized into two equal-sized treatment groups. Both IFN-β-1a (44μg) and IFN-α (3 MIU) were given subcutaneously three times a week, while ribavirin was given orally at 1,000-1,200 mg/day. Patients were treated for 24 weeks and followed for an additional 24 weeks. Results: After 24 weeks of treatment, six (60%) and four patients (40%) in the IFN-β-1a group and IFN-α groups, respectively, achieved viral clearance. The sustained virological response (SVR) at the end of the observation period was similar in both groups (40%). However, the baseline viral load was significantly higher (p=0.034) in the IFN-β-1a group than in the IFN-α group, and there were more HCV genotype 1 patients in the IFN-β-1a group (eight versus seven). The IFN-β-1a group was associated with similar adverse events in terms of frequency and severity. Conclusions: The SVR rate and safety profile were similar for the combination of IFN-β-1a and ribavirin and that of IFN-α and ribavirin. (Gut and Liver 2009;3:20-25)

An Investigation of Downcomer Boiling Effects During Reflood Phase Using TRAC-M Code

Chon Woo Chong,Lee Jae Hoon,Lee Sang Jong The Korean Society of Mechanical Engineers 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.5

The capability of TRAC-M code to predict downcomer boiling effect during reflood phase in postulated PWR LOCA is evaluated using the results of downcomer effective water head and Cylindrical Core Test Facility (CCTF) experiments, which were performed at JAERI. With a full height downcomer simulator, effective water head experiment was carried out to investigate the applicability of the TRAC-M best estimate LOCA code to evaluate the effective water head with superheated wall temperature in downcomer. In order to clarify the effect of the initial superheat of the downcomer wall on the system and the core cooling behaviors during the reflood phase, two sets of analysis were also performed with a CCTF. Results show that TRAC­M code tends to under-predict downcomer effective water head and core differential pressure. However, the code results show a good agreement with the experimental results in downcomer temperature, heat flux and pressure. Finally, both experiment and calculation showed that the downcomer water head with the superheated downcomer wall is lower than that of the saturated wall temperature.

A new waxy white grain wheat variety, “BaekChal” with pre-harvest sprouting and cold hardiness resistance and good cooking quality

Chon-Sik Kang,Kyeong-Hoon Kim,Young-Keun Cheong,Hag-Sin Kim,Young-Jin Kim,InDuck Choi,Jong-Chul Park,Sang-Hyun Shin,Jae-Han Son,Kyong-Ho Kim,Jong-Nae Hyun,Kee-Jong Kim,Chu Soo Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

“Baechal”, a winter wheat (Triticum aestivum L.) cultivar was developed by the National Institute of Crop Science, RDA, Iksan, Korea, during the period from 2006 to 2012. The heading and maturing dates of this variety were May 1 and June 5 in upland, and May 2 and June 8 in paddy field, respectively. It is an It is an awned, semi-dwarf and hard white wheat. Culm and spike length of “Baekchal” were 75cm and 8.7cm. It had lower test weight (794g/ℓ) and 1,000 grain weight (35.7g) than “Keumkang”. It showed moderate to pre-harvest sprouting, which lower rate of pre-harvest sprouting (13.7%) than “Keumkang”. “Baekchal” had similar ash content (0.47%) and protein content (13.1%) to “Keumkang”. It showed lower gluten content (9.6%), SDS-sedimentation volume (38.2㎖) and amylose content (6.5%) than “Keumkang”. It showed higher high viscosity (643BU), water absorption (213%), expansibility of cooking (357%). It showed different composition in HMW-GS compositios (2*), PPO18 (876bp), GBSS (waxy type) and Puroindolines composition compared th “Keumkang”. Average yield of “Baekchal” in the regional adaptation yield trial test was 4.89 ton/ha in upland and 4.83 ton/ha in paddy field. “Baekchal” would be suitable for the area above –10℃ of daily minimun temperature in January in Korean peninsula

A new wheat variety, “Hojoong” with pre-harvest sprouting resistance, low amylose content and good noodles quality

Chon-Sik Kang,Kyeong-Hoon Kim,Young-Keun Cheong,Hag-Sin Kim,Young-Jin Kim,InDuck Choi,Jong-Chul Park,Sang-Hyun Shin,Jae-Han Son,Kyong-Ho Kim,Jong-Nae Hyun,Kee-Jong Kim,Chu Soo Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

“Hojoong”, a winter wheat (Triticum aestivum L.) cultivar was developed by the National Institute of Crop Science, RDA, Iksan, Korea, during the period from 2006 to 2012. The heading and maturing dates of this variety were May 2 and June 10 in upland, and May 3 and June 7 in paddy field, respectively. It is an It is an awned, semi-dwarf and soft red winter wheat. Culm and spike length of “Hojoong” were 79cm and 9.1cm. It had lower test weight (803 g/ℓ) and 1,000 grain weight (39.5g) than “Keumkang”. It showed resistance to pre-harvest sprouting, which lower rate of pre-harvest sprouting (5.5%) than “Keumkang”. “Hojoong” had lower flour yield (66.7%) and ash content (0.38%) than “Keumkang”. It showed lower protein content (11.3%) and lower SDS-sedimentation volume (34.0㎖) and amylose content (20.5%) than “Keumkang”. It showed higher high viscosity (204BU) and lightness of noodle dough sheet (80.63). It showed different composition in HMW-GS compositios (2.2+12), PPO18 (876bp), GBSS B (null type) and Puroindolines composition compared th “Keumkang”. Average yield of “Hojoong” in the regional adaptation yield trial test was 5.51 ton/ha in upland and 5.10 ton/ha in paddy field. “Hojoong” would be suitable for the area above –10℃ of daily minimun temperature in January in Korean peninsula

A new wheat variety, “Joah” with pre-harvest sprouting resistance, high yield and good cake quality

Chon-Sik Kang,Kyeong-Hoon Kim,Sang-Hyun Shin,Young-Keun Chenog,Hag-Sin Kim,Young-Jin Kim,In Duck Choi,Kyong-Ho Kim,Kee-Jong Kim,Chul Soo Park 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

“Joah”, a winter wheat (Triticum aestivum L.) cultivar was developed by the National Institute of Crop Science, RDA, Iksan, Korea, during the period from 1997 to 2011. The heading and maturing dates of this variety were April 26 and June 8 in upland, and April 28 and June 6 in paddy field, respectively. It is an awned, semi-dwarf and soft winter wheat. Culm and spike length of “Joah” were 78 cm and 8.4 cm. It had lower test weight (763g/L) and l,000-grain weight (43.0 g) than “Keumkang”. It showed moderate to pre-harvest sprouting, which lower rate of pre-harvest sprouting (12.3%) than “Keumkang”. “Joah” had lower flour yield (66.3%) and ash content (0.33%) than “Keumkang”. It showed higher lightness (92.29) of flour color than “Keumkang”. It showed lower protein content (11.5%) and gluten content (10.7%) and lower SDS-sedimentation volume(29㎖) and mixing time of mixograph than “Keumkang”. It was showed higher amylose content and high viscosity than “Keumkang”. It showed different compositions in HMW-GS compositions (2.2+12), PPO 18 (876bp) and Puroindolines composition compared to “Keumkang”. “Joah” showed similar firmness (2.20N) and higher volume of sponge cake to “Keumkang”. Average yield of “Joah” in the regional adaptation yield trial was 6.44 ton/ha in upland and 5.26 ton/ha in paddy field. “Joah” would be suitable for the area above -10℃ of daily minimum temperature in January in Korean peninsula.

The Relationship between Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Measured by Controlled Attenuation Parameter

Chon, Young Eun,Kim, Kwang Joon,Jung, Kyu Sik,Kim, Seung Up,Park, Jun Yong,Kim, Do Young,Ahn, Sang Hoon,Chon, Chae Yoon,Chung, Jae Bock,Park, Kyeong Hye,Bae, Ji Cheol,Han, Kwang-Hyub Yonsei University College of Medicine 2016 Yonsei medical journal Vol.57 No.4

<P><B>Purpose</B></P><P>The severity of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) population compared with that in normal glucose tolerance (NGT) individuals has not yet been quantitatively assessed. We investigated the prevalence and the severity of NAFLD in a T2DM population using controlled attenuation parameter (CAP).</P><P><B>Materials and Methods</B></P><P>Subjects who underwent testing for biomarkers related to T2DM and CAP using Fibroscan® during a regular health check-up were enrolled. CAP values of 250 dB/m and 300 dB/m were selected as the cutoffs for the presence of NAFLD and for moderate to severe NAFLD, respectively. Biomarkers related to T2DM included fasting glucose/insulin, fasting C-peptide, hemoglobin A1c (HbA1c), glycoalbumin, and homeostasis model assessment of insulin resistance of insulin resistance (HOMA-IR).</P><P><B>Results</B></P><P>Among 340 study participants (T2DM, n=66; pre-diabetes, n=202; NGT, n=72), the proportion of subjects with NAFLD increased according to the glucose tolerance status (31.9% in NGT; 47.0% in pre-diabetes; 57.6% in T2DM). The median CAP value was significantly higher in subjects with T2DM (265 dB/m) than in those with pre-diabetes (245 dB/m) or NGT (231 dB/m) (all p<0.05). Logistic regression analysis showed that subjects with moderate to severe NAFLD had a 2.8-fold (odds ratio) higher risk of having T2DM than those without NAFLD (<I>p</I>=0.02; 95% confidence interval, 1.21–6.64), and positive correlations between the CAP value and HOMA-IR (ρ=0.407) or fasting C-peptide (ρ=0.402) were demonstrated.</P><P><B>Conclusion</B></P><P>Subjects with T2DM had a higher prevalence of severe NAFLD than those with NGT. Increased hepatic steatosis was significantly associated with the presence of T2DM, and insulin resistance induced by hepatic fat may be an important mechanistic connection.</P>

Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade

Chon, Hong Jae,Lee, Won Suk,Yang, Hannah,Kong, So Jung,Lee, Na Keum,Moon, Eun Sang,Choi, Jiwon,Han, Eun Chun,Kim, Joo Hoon,Ahn, Joong Bae,Kim, Joo Hang,Kim, Chan American Association for Cancer Research 2019 Clinical Cancer Research Vol.25 No.5

<P><B>Purpose:</B></P><P>Cancer immunotherapy is a potent treatment modality, but its clinical benefit depends on the tumor's immune profile. Here, we used mJX-594 (JX), a targeted and GM-CSF–armed oncolytic vaccinia virus, as a strategy to remodel the tumor microenvironment (TME) and subsequently increase sensitivity to αPD-1 and/or αCTLA-4 immunotherapy.</P><P><B>Experimental Design:</B></P><P>The remodeling of the TME was determined using histologic, flow-cytometric, and NanoString immune profiling analyses. JX was intratumorally injected into implanted Renca kidney tumors or <I>MMTV-PyMT</I> transgenic mouse breast cancers with or without αPD-1 and/or αCTLA-4. Various combination regimens were used to evaluate immunotherapeutic anticancer responses.</P><P><B>Results:</B></P><P>Intratumoral injection of JX remodeled the TME through dynamic changes in the immune system, as shown by increased tumor-infiltrating T cells and upregulation of immune-related gene signatures. This remodeling induced conversion of a noninflamed tumor into an inflamed tumor. JX virotherapy led to enhanced abscopal effects in distant tumors, with increased intratumoral infiltration of CD8<SUP>+</SUP> T cells. A depletion study revealed that GM-CSF is an indispensable regulator of anticancer efficacy of JX. Dual-combination therapy with intratumoral JX and systemic αPD-1 or αCTLA-4 further enhanced the anticancer immune response, regardless of various treatment schedules. Of note, triple combination immunotherapy with JX, αPD-1, and αCTLA-4 elicited the most potent anticancer immunity and induced complete tumor regression and long-term overall survival.</P><P><B>Conclusions:</B></P><P>Our results show that intratumoral JX treatment induces dramatic remodeling of the TME and more potently suppresses cancer progression with immune-checkpoint blockades by overcoming resistance to immunotherapy.</P>

Measurement-based Treatment of Residual Symptoms Using Clinically Useful Depression Outcome Scale: Korean Validation Study

Sang Won Jeon,Changsu Han,Young-Hoon Ko,Seo Young Yoon,Chi-Un Pae,Joonho Choi,Yong Chon Park,Jong-Woo Kim,Ho-Kyoung Yoon,Seung-Duk Ko,Ashwin A. Patkar,Mark Zimmerman 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.1

Objective: This study was aimed at evaluating the diagnostic validity of the Korean version of the Clinically Useful Depression Outcome Scale (CUDOS) with varying follow-up in a typical clinical setting in multiple centers. Methods: In total, 891 psychiatric outpatients were enrolled at the time of their intake appointment. Current diagnostic character-istics were examined using the Structured Clinical Interview for DSM-IV (41% major depressive disorder). The CUDOS was meas-ured and compared with three clinician rating scales and four self-report scales. Results: The CUDOS showed excellent results for internal consistency (Cronbach’s α ,0.91), test-retest reliability (patients at intake, r =0.81; depressed patients in ongoing treatment, r =0.89), and convergent and discriminant validity (measures of depres-sion, r =0.80; measures of anxiety and somatization, r =0.42). The CUDOS had a high ability to discriminate between different levels of depression severity based on the rating of Clinical Global Impression for depression severity and the diagnostic classi-fication of major depression, minor depression, and non-depression. The ability of the CUDOS to identify patients with major depression was high (area under the receiver operating characteristic curve=0.867). A score of 20 as the optimal cutoff point was suggested when screening for major depression using the CUDOS (sensitivity=89.9%, specificity=69.5%). The CUDOS was sensitive to change after antidepressant treatment: patients with greater improvement showed a greater decrease in CUDOS scores ( p <0.001). Conclusion: The results of this multi-site outpatient study found that the Korean version of the CUDOS is a very useful measure-ment for research and for clinical practice.