Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

Gliotoxin ameliorates TNBS-induced colitis through regulation of NF-kB, and up-regulation of HO-1

김상욱 ( Kim Sang Ug ),( Jay Min Oh ),( Yeon Hwa Kim ),( Jung Moo Hur ),( Kyo Sang Yoo ),( Yong Sung Kim ),( Joo Jin Yeom ),( Tae Hyeon Kim ),( Suck Chei Choi ),( Chang Duk Jun ),( Yong Ho Nah ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-

<Background & aims> During inflammation in colon, cells of the gut mucosa produce or express various inflammatory mediators, including IL-8, TNF-a and IL-1b, and intercellular adhesion molecule 1 (ICAM-1). These cytokines and chemokines have recently been

대호 간척기 토양의 염농도별 밭작물의 염해 평가

이승헌,류순호,설수일,안열,정영상,이상모 江原大學校 附設 環境硏究所 2001 環境硏究 Vol.18 No.-

This study was carried out to obtain the basic data for selecting the applicable crops in reclaimed land during desalinization period. A pot experiment was conducted with 5 different electrical conductivities of the saturated extracts (ECe 1, 3, 9, 14, and 16 dS·m^(-1)) of soils taken from the Dae-Ho reclaimed tidal lands. Eight crops (Chinese cabbage, radish, tomato, red pepper, buckwheat, soybean, sesame, and green perilla) were grown for 37days. Plant height and number of leaves were surveyed on 2 and 4 weeks after seeding, and on harvest time (5 weeks). After harvest, dry weights of harvested crops were measured and soil chemical properties were analyzed. Emergence rates of crops were comparatively high except sesame. For sesame, there was no emergence at ECe over 3 dS·m^(-1). Growth and dry weight decreased significantly as increasing ECe. The ECe which decreased 50% of dry weight index were 14.2 dS·m^(-1) for radish, 11.4 dS·m^(-1) for Chinese cabbage, 10.2 dS·m^(-1) for tomato for red pepper, 8.9 dS·m^(-1) for buckwheat and green perilla, 8.6 dS·m^(-1) for soybean, and 8.9 dS·m^(-1) for tomato. At higher ECe that start the growth inhibition, increasing 1 dS·m^(-1) in ECe, 7.7, 6.5, 5.9, 5.6, 5.2, and 4.9% of dry weight decreased for buckwheat, green perilla, Chinese cabbage, radish, soybean, and tomato (red pepper), respectively. The critical value of ECe for crop survival except sesame was 15.4~23.1 dS·m^(-1).

인슐린종에 음폐된 신경정신과적 증상 평가

유희정,이성동,김헌수,민병근,박인호 울산대학교 의과대학 1994 울산의대학술지 Vol.3 No.1

The authors experienced a patient with insulinoma presented with neuropsychiatric symptoms. It was demonstrated that Whipple's triad is highly suggestive of the presence of an insulinoma. Therefore physicians and/or psychiatrists, who refer patients with insulinoma to third institution, always have a alertness to neuropsychiatric symptoms of insulinoma and Whipple's triad. This case also illustrated the persistence and cooperation between psychiatric and medical teams including the involvement of a neurologist, endocrinologist, and surgeon for diagnosis and treatment planning of patient with insulinoma.

Voronoi diagram을 구하는 알고리즘에 관한 연구

柳基永,金昇浩 경북대학교 공과대학 1987 工大硏究誌 Vol.16 No.-

This paper presents an O(n) on-line algorithm for finding voronoi diagram, when we are given voronoi diagram and another new point.

간세포암의 십이지장침윤에 의한 상부위장관 출혈 1 예

유태현,한광협,박성하,김형길,문영명,한재호,조상호 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2

Recent advances in both the diagnosis and treatment of hepatocellular carcinoma have improved the prognosis and changed the clinical significance of the recently increasing distant metastases. Distant metastases found after successful treament of the primary lesions are of great clinical significance for the treatment of hepatocellular carcinoma. The duodenum is a rare site of hematogenous metastases or direct invasion from hepatocellular carcinoma. A 23 year old man was admitted with upper gastrointestinal bleeding. He had been diagnosed with hepatocellular carcinoma and treated by a left lobectomy and chemoembolization. The patient was admittted for 12 months after the treatment of the primary tumor. Endoscopic examination revealed a mass in the duodenal bulb that protruded into the lumen. He died due to massive hematemesis. We report on a rare case of hepatocellular carcinoma with duodenal invasion in a 23-year-old male patient.

도덕적 일탈행위에 대한 청소년의 허용성과 정신건강의 관련성

유영금,반건호,김상윤 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2

The purpose of this study was to examine the relationship between adolescents' degree of permissiveness on moral transgressions and their mental health. 191 adolescents of junior and senior high school from Pusan were presented with 14 multifaceted domains consisted of moral, conventional and personal transgressions. And their psychological symptoms were obtained by 'Symptom Checklist-90-Revision'. Older adolescents(senior high schoolers) judged multifaceted events as personal and treated more permissible than younger adolescents(junior high schoolers). There were some disparities in their judgment between about story situation and about their own real situation: they judged more permissibly in their own cases than in story ones. There were negative correlations between mental health and permisiveness on moral transgressions. This result indicated that in adolescents' domain distinction some psycholgical symptoms, which were underestimated by cognitive and intuitive moral developmental theories, seem to be related.

정상체중성인과 과체중성인의 거골-제1종족골 및 종골하면-제1종족골하면 관절간 각도 차이에 대한 연구

유문집,김명호,유석주,이성철,박진영 단국대학교 1997 論文集 Vol.31 No.-

Normal feet have the longitudinal arch for the distribution of the weight. The longitudinal arch is known lateral and medial longitudinal arch. Collapsed arch of the foot is flat foot and it is the cause of the foot pain. Of course the low arch does not always make a foot problem in sports and daily activity. Longitudial foot arch is visible in the standing foot lateral radiograph, Harris mat and visual observation. In Radiographic study the lateral Talo-lst Metatarsal angle is known in standing foot lateral film. But the longitadinal medial arch is not correctly obtained in Talo-lst Metatarsal angle. So this study for Calcaneo-lst metatarsal angle in standing lateral foot radiograph is more valuable angle in medial longitadinl arch. And we do the study on difference in the longitadinal arch in normal weight versus overweight person.

협착관내에서 멱법칙 비뉴턴 유체와 점탄성 유체의 유동특성에 관한 연구

유상신,서상호 한국항공대학교 1993 論文集 Vol.31 No.-

비뉴턴 유체의 구성방정식 중에서 수정멱법칙모델을 이용하여 원형단단면을 갖는 직선관, 급격축소-급격확대 협착관, 그리고 점차축소-점차확대관 내에서의 유동특성을 수치모사하였다. 점차축소-점차확대관은 직선으로 연결되는 경우와 코사인곡선으로 이루어지는 경우로 구분하였다. 비뉴턴 유체중에서 저항감소현상을 나타내는 점탄성유체를 이용하여 급격축소-급격확대 협착관에서의 유동특성을 실험적으로 결정하였다. 완전히 발달된 층류유동에서 멱법칙 지수 n가 작아질수록 속도 형상은 관의 중앙부분에서 평탄해지고 압력손실은 증가한다. 급격축소-급격확대 협착관이 점차축소-점차확대협착관에서 곡선의 영향은 별로 크지 않다. 점탄성 유체의 압력손실계수는 층류영역에서 Reynolds수의 함수로 나타나며, 물보다 크게 나타난다. 협착비율과 협착길이비가 클수록 압력손실계수는 크게 나타난다. The modified power law model for a non-Newtonian fluid is employed to simulate the interanal flows of smooth straight tube, sudden contraction-sudden sxpansion tube, and gradual contraction-gradual expansion tube. Geometries of the gradual contraction-gradual expansion tubes are made of straight line or cosine curve. Experimental investigations using the drag reducing polymer solutions that are known as the viscoelastic fluids are conducted for the internal flows with sudden cotraction-sudden expansion tubes. The velocity profile in the contral region becomes flat and the pressure loss increases as the power law index n decreases in the fully developed laminar flow. The pressure loss of the sudden contraction-sudden expansion tube is larger than that of the gradual contraction-gradual expansion tube. The effect of index n on the sudden contraction-sudden expansion is greater than that on the gradual contraction-gradual expansion tube. The curvature effect of the gradual contraction-gradual expansion tube is not pronounced. The pressure loss coefficients of viscoelastic fluid is larger than that of water for the same Reynolds number. The loss coefficient of the stenosed tube increases as the percent contraction ratio and the length to diameter ratio increase.

자수용 DNC검증 및 편집 시스템 개발에 관한 연구

유우식,장성호 金烏工科大學校 1993 論文集 Vol.14 No.-

Presented in this paper is a DNC verification and editing system architecture for embroidery manufacturing. Embroidery machines are numerically controlled machines with multi head, but they have not standard RS-232C communication port in general. So embroidery machines receive NC data from reels of 1 in . wide tape containing holes. But punched tape as an input media has many defects. In this paper, we present DNC(Direct Numerical Control) verification system eliminating punched tape. With the proposed system, NC data editing algorithm are also presented.