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Absolute Stereochemistry Determination of Tetrin B
Ryu, Geon-seek,Choi, Byoung-Wook,Lee, Bong-Ho Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.10
The absolute stereochemistry of tetrin B (1), an antifungal antibiotic isolated from a soil actinomycete was determined by applying Rychnovsky analysis, the modified Mosher method, and CD exciton chirality to be 4R, 5R, 7S, 9R, 11S, 12R, 13S, 15R, 24S, and 25R.
A New Antioxidant Monoterpene Glycoside, $\alpha$-Benzoyloxypaeoniflorin from Paeonia suffruticosa
Ryu, Geon-Seek,Park, Eun-Kyung,Joo, Jeong-Hoon,Lee, Bong-Ho,Choi, Byoung-Wook,Jung, Duk-Sang,Lee, Nam-Ho The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.2
$\alpha$-Benzoyloxypaeoniflorin (1), a new antioxidant monoterpene $\alpha$-glycoside anomer was isolated from Paeonia suffruticosa along with known compounds, $\beta$-benzoyloxypaeoniflorin (2), paeonolide, paeoniflorin and mudanpioside H. The structure of 1 has been determined by comparing spectral data with those of $\beta$-Benzoyloxypaeoniflorin(2). Compound 1 exhibited moderately potent radical scavenging activity on DPPH radical.
The Radical Scavenging Effects of Stilbene Glucosides from Polygonum multiflorum
Ryu, Geon-Seek,Ju, Jeung-Hoon,Park, Yong-Ju,Ryu, Shi-Yong,Choi, Byoung-Wook,Lee, Bong-Ho The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-Ο-$\beta$-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity ($IC_{50}$, 40 $\mu$M), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity ($IC_{50}$, 0.38 $\mu$M).
Ryu, Geon-Seek,Park, Soo-Hee,Kim, Eun-Sook,Choi, Byoung-Wook,Ryu, Shi-Yong,Lee, Bong-Ho The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.10
Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6, 10, 14-trimethylpentadeca-5, 10-dien-2, 12-dione and (5E,9E,13E)-6, 10,4-trimethylpentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with $IC_{50}$ values of 65.0∼48.0 and 34.0∼23.0 $\muM$, respectively.
이봉호,유건식,이은석,강기정,황도연,홍남두,최병욱,Lee, Bong-Ho,Ryu, Geon-Seek,Lee, Eun Seog,Kang, Kye-Jung,Hwang, Dho-Yeun,Hong, Nam-Doo,Choi, Byoung-Wook 한국생약학회 1997 생약학회지 Vol.28 No.4
We have tested 101 species traditional medicinal plants on Acetylcholinester ase inhibition. Among them. Caesalpina sappan. Cnidium offcinale, Coptis japonica, Ephedra sinica, Eribotrya japonica, Gardenia jasminoides, Liriope platyphylla, Lonicera japonica, Paeonia suffruticosa, Phyllostachys nigra, Polygonum multiflorum, Prunella vulgaris, Rheum undulatum, Salvia miltiorrhiza and Uncaria rhynchophylla showed strong inhibition potency over 88%. In addition, Aconitum carmichaeli, Caesalphina sappan, Cinnamomun japonica, Citrus unshiu, Hordeum vulgare, Glycine max and Rehmannia glutinosa showed relatively good inhibition potency over 80%.
Bae, Ui-Jin,Park, John,Park, Il Woon,Chae, Byung Min,Oh, Mi-Ra,Jung, Su-Jin,Ryu, Geon-Seek,Chae, Soo-Wan,Park, Byung-Hyun World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.3
<P>The prevalence of metabolic diseases has risen globally in parallel with the obesity epidemic over the past few decades. Green tea has been reported to have metabolically beneficial effects on obesity; however, the mechanism by which green tea regulates lipid metabolism is not clearly understood. Male c57BL/6 mice were fed a normal chow diet, a high-fat diet (HFD), or an HFD supplemented with various doses of epigallocatechin gallate-rich green tea extract (GTE) for 12 weeks. GTE supplementation reduced body weight gain, prevented hepatic fat accumulation, decreased hypertriglyceridemia, and improved hyperglycemia and insulin resistance in HFD-fed mice. The underlying mechanisms of these beneficial effects of GTE might involve the upregulation of sirtuin 1 and AMP activated protein kinase (AMPK) and the downregulation of enzymes related to <I>de novo</I> lipogenesis. Consistent with the <I>in vivo</I> findings, GTE increased the expression and activity of sirtuin 1, enhanced the binding of sirtuin 1 to liver kinase B1 (LKB1) and subsequent deacetylation of LKB1, and reduced triglyceride accumulation in HepG2 cells. These results suggest the possible therapeutic potential of dietary epigallocatechin gallate-rich GTE supplementation for preventing the development and progression of hepatic steatosis and obesity.</P>