IT 기술력으로 대한민국을 연결하다: 메쉬코리아의 성공 메커니즘 분석

유정범(Jeong-bum Rhyu),박재홍(Jae-hong Park),이동근(Dong-gun Lee),박기찬(Kichan Park) 한국경영학회 2021 Korea Business Review Vol.25 No.신년 특별호

온라인 쇼핑 시장의 발전과 코로나19 바이러스의 확산으로 비대면 생활 시대가 점진되면서 라스트 마일 시장(Last Mile Market)은 유래 없는 호황을 맞이하고 있다. 이제는 배송의 대상이 음식에 국한되지 않고 편의점, H&B 스토어 등 비(非)음식분야까지 서비스가 보편화 되었다. 본 연구는 라스트 마일 업계에서 IT(Information Technology) 기술력을 기반으로 성공적인 성장을 거듭하고 있는 메쉬코리아의 성공 사례를 자원기반이론(RBV)의 확장 모델로 평가되는 SER-M 패러다임을 통해 분석했다. 주체의 특성, 환경적 조건, 자원의 역량요인 등이 융합 · 결합을 통해 어떠한 메커니즘을 형성하여 성공할 수 있었는지, 그리고 더 큰 성장을 위해 어떤 도전과제에 직면하고 있는지를 살펴보았다. 분석결과, 선순환적 성장 메커니즘을 구축시켜준 주요 원동력은 다음과 같이 나타났다. 첫째, 주체변수의 특성은 창업가의 기업가정신으로 나타났다. 메쉬코리아의 창업주 유정범 대표는 아버지의 장례식장에서 배달 시스템의 비효율성을 보면서 이를 개선하기 위해 창업을 결심했다. 유대표의 기업가 정신은 현장 중시 철학인 ‘우문현답’, 모두에게 이익이 되도록 하려는 모토인 ‘세상에서 가장 깨끗한 1원의 가치’, 그리고 흔히 라이더(Rider)라 부르는 배송기사들에 대한 ‘섬김의 리더십’실천으로 부각된다. 둘째, 성공을 위한 환경적 요인은 온라인 쇼핑이 활성화되어 라스트 마일 사업이 확대된 시장 환경, 인공지능(AI), 빅데이터 등 다양한 기술의 발전에 힘입어 신유통 등 물류 시장에 혁신의 바람을 불게 한 시대적 환경, 그리고 코로나-19 신종 바이러스 확산에 따른 강력한 사회적 거리두기 조치등의 정책적 환경이 새로운 기회를 제공한 것으로 나타났다. 셋째, 유정범 대표의 기업가 정신과 코로나 팬데믹 환경에 더하여 메쉬코리아가 보유하고 있는 인적, 물적 자원을 업계에서 유일하게 직영 구조로 운영하는 전략적 자원으로 구축 및 활용함으로써 글로벌 배송 업체까지도 벤치마킹하고자 하는 메쉬코리아의 선순환적 성공 메커니즘이 사내외로 확산되고 있음을 확인하였다. 논문의 마지막 부분에서는 대부분의 사업과 산업이 어려움에 처한 상황에서도 배송업계에 대한 낙관적 전망에 따라 포화상태로 접어들고 있는 라스트 마일 업계에서 메쉬코리아가 향후 직면하게 될 도전과제에 대하여 살펴보았다. 본 연구는 메쉬코리아의 성공적 성장사례를 통해 스타트업 기업들의 시장진입 및 성장전략, 그리고 그 과정에서 직면하게 되는 이슈와 과제를 어떻게 대응하고 극복해 갈 것인지에 대한 방법을 토론하는 데 그 의미를 두고자 하였다. The Last Mile Market is experiencing an unprecedented boom due to advent of the non-faceto-face life era caused by the development of the online shoppong market and the spread of the COVID-19. The target of delivery is not limited to food, and services have become common in non-food fields such as convenience stores and H&B stores. This study analyzed the success cases of Mesh Korea, which has achieved successful results based on IT(Information Technology) in the Last Mile Industry, through a ser-M model. and this study examines what kind of mechanisms the subject, environment, and resourse factors could have formed and succeeded through fusion and combination, and what challenges they face for greater growth. CEO Rhyu Jeong-beom, founder of Mesh Korea, decided to start a business in order to improve the inefficiency of the delivery system at his father’s funeral. His entrepreneurship is “Woo Moon Hyeon-dap(The answer to our problem is in the field),” a philosophy that focuses on the field, “the cleanest value of 1 won in the world,” and the leadership of serving delivery riders. Environmental factors for success were analyzed by dividing in to Market Environment in which the Last Mile Market has expanded due to active online shopping, The environment of the times in which various technologies such as AI(artificial intelligence) and big data have been developed to blow the wind of innovation in the logistics market. and Policy Environment such as strong social distancing following the spread of the COVID-19. This study presents the challenges that Mesh Korea will face in the future in the last mile industry, which is saturated with indyustry optimism. And it is meaningful in discussing how to overcome the start-up and growth of start-up companies and the challenges they will face through the case of Mesh Korea.

지방흡입술 후 괴사성 근막염과 동반하여 발생한 독성 쇼크 증후군

유희선(Hee Seon Rhyu),박민호(Min Ho Park),김정철(Jung Chul Kim),류성엽(Seong Yeop Rhyu),박영규(Young Kyu Park),김형록(Hyeong Rok Kim),김동의(Dong Yi Kim),김영진(Young Jin Kim),김신곤(Shin Khon Kim),주재균(Jae Kyun Ju) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.3

The Changes of Adjacent Intervertebral Discs after Lumbar Spine Immobilization in Rabbit

Rhyu, Kee Won,Kim, In CATHOLIC MEDICAL CENTER 1996 Bulletin of the Clinical Research Institute Vol.24 No.2

It has been known that the mechanical force loaded on spinal segments is changed after lumbar spinal immobilization. The abnormally high stress concentrated on the adjacent segments to the fused site results in degenerative changes of the intervertebral discs. In the present study, we investigated the changes following lumbar spinal immobilization in the spinal segment including intervertebral disc located just above the fused segment to relate the radiological findings of the spinal segment with the histopathological findings of the intervertebral disc using 20 adult rabbits, 4 control and 16 experimental group. Bilateral pedicular screw and plate were fixed at L6-7 spinal segment of experimental group. The experimental group were sacrificed 4, 8, 12 and 16 weeks after the operation. The results were as follows: 1. On the radiological examination of the L5-6 segment, the end plate sclerosis has been observed since 8th week after operation. At 12th week, the evidence of angular difference was seen. The more prominent findings for degenerative change such as anterior traction spur and angular difference were seen at 16th week. 2. Grossly, the mild discoloration of the intervertebral disc was seen at 4th week after operation. From 8th week, the degenerative changes such as discoloration, dehydration, and fibrosis were detected and were more prominent at 12th and 16th week. 3. Histologically, amorphous debris were seen from 4th week after operation in the nucleus pulposus. At 8th week, increased fibre bundles and chondroid cells were observed. The junction between the annulus fibrosus and nucleus pulposus were progressively distorted. From 12th week, the cluster of chondroid cells and chondroid metaplasia were formed. No definite demarcation between nucleus pulposus and annulus fibrosus was observed. These changes were more definite at 16th week. In the endplate cartilage, spindle shape of chondrocytes and loss of columnar cellular arrangement were detected from 8th week. At 12th week, the microfractures of endplate cartilage and osteoid formations were observed. At 16th week, it was unable to notice the borderline of the endplate cartilage and more osteoid formations were observed. On the stain for the mucopolysaccharides, the evidence of neutral mucopolysaccharides were observed. After 12th week, the neutral mucopolysaccharide and chondroid metaplasia were more prominent. 4. In intervertebral disc, more severe degenerative changes were noticed at the posterior parts of nucleus pulposus and annulus fibrosus. Above results suggest that the posterior spinal immobilization seems to accelerate the degenerative changes in the adjacent intervertebral disc above the immobilization. And these changes were more prominent at the posterior part of the intervertebral disc.

Application of Three-Dimensional Light Microscopy for Thick Specimen Studies

Rhyu, Yeon Seung,Lee, Se Jeong,Kim, Dong Heui,Uhm, Chang-Sub Korean Society of Microscopy 2016 Applied microscopy Vol.46 No.2

The thickness of specimen is an important factor in microscopic researches. Thicker specimen contains more information, but it is difficult to obtain well focused image with precise details due to optical limit of conventional microscope. Recently, a microscope unit that combines improved illumination system, which allows real time three-dimensional (3D) image and automatic z-stack merging software. In this research, we evaluated the usefulness of this unit in observing thick samples; Golgi stained nervous tissue and ground prepared bone, tooth, and non-transparent small sample; zebra fish teeth. Well focused image in thick samples was obtained by processing z-stack images with Panfocal software. A clear feature of neuronal dendrite branching pattern could be taken. 3D features were clearly observed by oblique illumination. Furthermore, 3D array and shape of zebra fish teeth was clearly distinguished. A novel combination of two channel oblique illumination and z-stack imaging process increased depth of field and optimized contrast, which has a potential to be further applied in the field of neuroscience, hard tissue biology, and analysis of small organic structures such as ear ossicles and zebra fish teeth.

首都圈地域에서 土壤의 酸性化에 의한 리기다소나무의 生長 減少

Rhyu, Tae-Cheol,Kim, Kee-Dae,Kim, Joon-Ho 한국생태학회 1994 Journal of Ecology and Environment Vol.17 No.3

수도권에서 보고된 리기다소나무 생장감소의 원인을 밝히기 위하여 33장소의 리기다소나무 숲에서 교목의 밀도, 수령 및 토양의 물리화학적 특성을 조사하였다. 토성을 제외하고 토양의 물리적 특성들은 도심지와 전원지에서 차가 없었다. 그러나 토양의 pH값, 염기포화도 및 염기성 양이온 함량은 전원지에 비해 도심지에서 낮았지만, 수용성 Al 함량과 S함량은 그 반대였다. 도심지의 토양산성화는 산성강하물에 의한 영향으로 해석된다. 다중회귀분석 결과, 수도권에서 리기다소나무 생장은 토양의 가비중<토양의 Al 함량<교목의 밀도<토양의 Mg 함량<수령의 순으로 영향이 컸다. 결론적으로 수도권에서 리기다소나무 생장의 감소는 1차적으로 토양산성화가 주요한 요인이었을 것으로 판단된다. To elucidate the cause of growth decline of pitch pine (Pinus rigida) in Seoul, tree density, tree age and physico-chemical properties of soils were investigated at 33 sites of pitch pine forests in metropolitan Seoul, its vicinity and rural areas. The physical properties of soils except for soil texture in Seoul did not differ from those in rural areas. pH values, base saturation, and Ca and Mg contents of soils in Seoul, however, were significantly lower than those in suburbs and rural areas. In contrast, soluble Al and $S0_4^{2-}-S$ contents in Seoul were higher than those in rural areas. Low pH of forest soils in Seoul and suburbs seems to be caused by acid deposition. According to multiple regression analysis, growth of pitch pine in Seoul was affected by several factors in the following order: soil bulk density < Al content of soils < tree density < Mg contents of soil < tree age. We concluded that the acidification of forest soil can be a predisposing factor for the growth decline of pitch pine in metropolitan areas.

首都圈地域에서 리기다소나무 잎과 잔뿌리 속의 陽이온 부족

Rhyu, Tae-Cheol,Kim, Kee-Dae,Kim, Joon-Ho 한국생태학회 1994 Journal of Ecology and Environment Vol.17 No.3

수도권과 그 주변 지역의 33지소의 리기다소나무 숲에서 리기다소나무 잎과 잔뿌리의 주요이온의 함량을 정량하였다. 잎 속의 N, P, K 및 Mg 함량운 전년도 잎에 비해 당해연도 잎속에 높았지만, Al과 Ca은 그 반대였다. 잎 속의 N, P, K 및 Al 함랴은 지역간의 차이가 없었지만, Ca과 Mg 함량은 전원지에 비해 도심지에서 낮았다. 그러나 잎속의 N/Ca와 N/Mg의 비의 값은 전원지에보다 도심지에서 컸다. 표토 잔뿌리 속의 Mg 함량은 도심으로부터 거리가 멀어짐에 따라 증가하였으나, 심층토 잔뿌리 속의 Al 함량은 그 반대였다. 토양층 잔뿌리 속의Al 함량은 도심지보다 전원지에서 낮았다. 토양층 잔뿌리속의 Al 함량은 낙엽층의 잔뿌리에 비하여 2~3배 높았다. 그리고 표토보다 심층토에 존재하는 잔뿌리 속에 Al 함량이 높았다. 그러므로 수도권 지역에서 리기다소나무의 생장감소는 조직 속의 Ca과 Mg 부족, N/Ca과 N/Mg 비의증가 및 잔뿌리 생장에 대한 Al 독성에 있었다. 그리고 수도권 지역에서 잔뿌리의 비정상적인 분포는 산성토양에서 Al 독성에 의한 잔뿌리의 생장감소가 그 원인으로 해석된다. The contents of major elements were determined in current-year and previous-year needles and fine roots of pitch pine (Pinus yzgida) at 33 sites in Seoul and its vicinity. Contrary to Ca and Al in needles, N, P, Mg and K contents in current-year needles were higher than those in previous-year needles. The N, P, K and Al contents in current-year needles in Seoul were not significantly different from those in rural areas. In contrast, Ca and Mg contents in needles in Seoul were significantly lower than those in suburbs and rural areas. The N /Ca and N /Mg ratios in needles in urban Seoul were higher than those in rural areas. Mg contents in fine roots in soil of 0-5 cm depth increased along with distance from the center of Seoul, while Al contents in fine root in soil of 5-10 cm depth decreased along with distance from the center of Seoul. Al contents in fine roots in soil layer in Seoul and suburbs were higher than those in rural areas. Al contents in fine roots in litter layer were 1 /3 - 1 /2 times lower than those in soil layer for all areas. A1 content in fine roots in deep soil was higher than that in top soil. Therefore growth decline of pitch pine in Seoul and suburbs was thought to be caused by Ca and Mg deficiency in plant tissues and Al toxicity to fine roots. Abnormal vertical distribution of fine roots of pitch pine in Seoul and its vicinity were interpreted as the result of growth reduction of fine roots by Al toxicity in deep layer of acid soil.

Role of Reactive Oxygen Species in TGF-β1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells

Rhyu, Dong-Young,Yang, Yanqiang,Ha, Hun-Joo,Lee, Geun-Taek,Song, Jae-Sook,Uh, Soo-Taek,Lee, Hi-Bahl 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14

Epithelial-mesenchymal transition (EMT) plays an important role in renal tubulointerstitial fibrosis and TGF-β1 is the key inducer of EMT. Phosphorylation of Smad proteins and/or mitogen-activated protein kinases (MAPK) is required for TGF-β1-induced EMT. Because reactive oxygen species (ROS) are involved in TGF-β1 signaling and are upstream signaling molecules to MAPK, this study examined the role of ROS in TGF-β1-induced MAPK activation and EMT in rat proximal tubular epithelial cells. Growth-arrested and synchronized NRK-52E cells were stimulated with TGF-β1 (0.2 to 20 ng/ml) or H₂0₂ (1 to 500 μM) in the presence or absence of antioxidants (N-acetylcysteine or catalase), inhibitors of NADPH oxidase (diphenyleneiodonium and apocynin), mitochondrial electron transfer chain subunit I (rotenone), and MAPK (PD 98059, an MEK [MAP kinase/ERK kinase] inhibitor, or p38 MAPK inhibitor) for up to 96 h. TGF-β1 increased dichlorofluorescein-sensitive cellular ROS, phosphorylated Smad 2, p38 MAPK, extracellular signal-regulated kinases (ERK)1/2, α-smooth muscle actin (α-SMA) expression, and fibronectin secretion and decreased E-cadherin expression. Antioxidants effectively inhibited TGF-β1-induced cellular ROS, phosphorylation of Smad 2, p38 MAPK, and ERK, and EMT. H₂0₂ reproduced all of the effects of TGF-β1 with the exception of Smad 2 phosphorylation. Chemical inhibition of ERK but not p38 MAPK inhibited TGF-131-induced Smad 2 phosphorylation, and both MAPK inhibitors inhibited TGF-β1- and H₂0₂-induced EMT. Diphe-nyleneiodonium, apocynin, and rotenone also significantly inhibited TGF-β1-induced ROS. Thus, this data suggest that ROS play an important role in TGF-β1-induced EMT primarily through activation of MAPK and subsequently through ERK-directed activation of Smad pathway in proximal tubular epithelial cells.

Expression of Human Endogenous Retrovirus <i>env</i> Genes in the Blood of Breast Cancer Patients

Rhyu, Dong-Won,Kang, Yun-Jeong,Ock, Mee-Sun,Eo, Jung-Woo,Choi, Yung-Hyun,Kim, Wun-Jae,Leem, Sun-Hee,Yi, Joo-Mi,Kim, Heui-Soo,Cha, Hee-Jae MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.6

<P>Human endogenous retroviruses (HERV) <I>env</I> proteins have been recently reported to be significantly up-regulated in certain cancers. Specifically, mRNA and protein levels of HERV-K (HML-2) are up-regulated in the blood plasma or serum of breast cancer patients. Here, we collected blood samples of 49 breast cancer patients and analyzed mRNA expressions of various HERVs <I>env</I> genes including HERV-R, HERV-H, HERV-K, and HERV-P by real-time PCR. The expression of <I>env</I> genes were significantly increased in the blood of primary breast cancer patients but were decreased in patients undergoing chemotherapy to a similar level with benign patients. When we compared the group currently undergoing chemotherapy and those patients undergoing chemotherapy simultaneously with radiotherapy, HERVs <I>env</I> genes were reduced more in the chemotherapy only group, suggesting that chemotherapy is more effective in reducing HERV <I>env</I> gene expression than is radiotherapy. Among chemotherapy groups, HERV <I>env</I> gene expression was the lowest in the taxotere- or taxol-treated group, suggesting that taxotere and taxol can reduce HERVs <I>env</I> expression. These data suggest the potential to use HERVs <I>env</I> genes as a diagnosis marker for primary breast cancer, and further studies are needed to identify the mechanism and physiological significance of the reduction of HERV <I>env</I> gene expression during chemotherapy.</P>

Role of Reactive Oxygen Species in TGF-β1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells

Rhyu, Dong-Young,Yang, Yanqiang,Ha, Hun-Joo,Lee, Geun-Taek,Song, Jae-Sook,Uh, Soo-Taek,Lee, Hi-Bahl 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16

Epithelial-mesenchymal transition (EMT) plays an important role in renal tubulointerstitial fibrosis and TGF-β1 is the key inducer of EMT. Phosphorylation of Smad proteins and/or mitogen-activated protein kinases (MAPK) is required for TCP-β1-induced EMT. Because reactive oxygen species (ROS) are involved in TCF-β1 signaling and are upstream signaling molecules to MAPK, this study examined the role of ROS in TGF-β1-induced MAPK activation and EMT in rat proximal tubular epithelial cells. Growth-arrested and synchronized NRK-52E cells were stimulated with TGF-β1 (0.2 to 20 ng/ml) or H_(2)O_(2) (1 to 500 ㎛) in the presence or absence of antioxidants (N-acetylcysteine or catalase), inhibitors of NADPH oxidase (diphenyleneiodonium and apocynin), mitochondrial electron transfer chain subunit I (rotenone), and MAPK (PD 98059, an MEK [MAP kinase/ERK kinase] inhibitor, or p38 MAPK inhibitor) for up to 96 h. TGF-β1 increased dichlorofluoresceinsensitive cellular ROS, phosphorylated Smad 2, p38 MAPK, extracellular signal-regulated kinases (ERK) 1/2, α-smooth muscle actin (α-SMA) expression, and fibronectin secretion and decreased I-cadherin expression. Antioxidants effectively inhibited TGF-β1-induced cellular ROS, phosphorylation of Smad 2, p38 MAPK, and ERK, and EMT. H_(2)O_(2) reproduced all of the effects of TGF-β1 with the exception of Smad 2 phosphorylation. CHemical inhibition of ERK but not p38 MAPK inhitited TGF-91-induced Smad 2 phosphorylation, and both MAPK inhibitors inhibited TGF-β1- and H_(2)O_(2)-induced EMT. Diphe-nyleneiodonium, apocynin, and rotenone also significantly inhibited TGF-β1-indured ROS. Thus, this data suggest that ROSplay an important role in TGF-β1-induced EMT primarily through activation of MAPK and subsequently through ERK-directed activation of Smad pathway in proximal tubular epithelial cells.

Scanning Electron Microscopic Observation of Human Skin Replica

Rhyu, Yeon-Seung,Chung, Ye-Ji,Uhm, Chang-Sub Korean Society of Microscopy 2010 Applied microscopy Vol.40 No.4

The skin is the largest organ of the integument system whose surface is closely related with many physiological and pathological conditions. Various methods are used to understand the structural and functional status of human skin. We would like to present usefulness of scanning electron microscopic (SEM) observation of skin replica and its significance of training module for a novice. The silicon replicas from several regions of the body (hand, finger, forearm, lip, and face) were casted by applying Exafine$^{(R)}$ mixture. The positive replicas were prepared by applying EPON 812 mixture on negative silicon replicas. Some of the negative silicon replicas were cut with a razor blade and surface profiles were observed. The negative and positive replicas were coated with platinum and were observed under the scanning electron microscope. We could investigate the detailed structures of the human skin surface without any physical damage to the subject. The positive replicas depicted real surface structure of the human skin vividly. The cross sectional view of the negative silicon replicas provided surface profile clearly. The scanning electron microscopic observation of the human skin replicas would be useful to study skin surface structures and to evaluate medical and esthetical applications.