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Rhie, Arang,Park, Weon Seo,Choi, Moon Kyung,Kim, Ji-Hyun,Ryu, Junsun,Ryu, Chang Hwan,Kim, Jong-Il,Jung, Yuh-Seog Williams & Wilkins Co 2015 Medicine Vol.94 No.50
ABSTRACT: Recently increasing high-risk HPV+ OSCC exhibits unique clinical and molecular characteristics compared to HPV-unrelated (HPV−) counterpart. Genomic copy number variations (CNVs), unique in HPV+ OSCCs, and their role for the prognosis prediction remains poorly studied. Here, we analyzed the distinct genomic copy number variations (CNVs) in human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma (OSCC) and their role as a prognosticator after curative resection.For 58 consecutive, Korean OSCC patients that underwent surgery-based treatment with median 10 years of follow-up, HPV-related markers, and genome-wide CNV analysis were analyzed. Clinical associations between the CNV profile and survival analyses were followed.p16 expression predicted the overall survival (OS) (hazard ratio [HR] = 0.27, confidence interval [CI]: 0.39–0.80, P = 0.0006) better than HPV L1 PCR (HR = 0.83, CI: 0.66–1.29, P = 0.64), smoking, or other variables. Although the overall number of CNVs was not significantly different, 30 loci showed unique CNV patterns between the p16 and p16− groups. A region containing PRDM2 was amplified only in the p16 group, whereas EGFR and 11q13.3 showed increased amplification in p16− counterpart. Loss of a locus containing FGF18 led to a worse, but gain of region including CDK10 and RAD18 led to better overall survival (OS) in all OSCC patients. Meanwhile, subgroup analysis of p16 OSCC revealed that amplification of regions harboring HRAS and loss of locus bearing KDR led to better OS.p16 OSCC exhibit distinct CNV patterns compared with p16− counterpart. Specific patterns of CNVs predict better survival, especially in p16 OSCC. This might allow better insights of the outcome after curative resection for HPV+ and HPV− OSCC.
DETERMINATION OF CATECHOLAMINES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY : Analytical Methodlogy
Rhie, Fyo-Jae,Oh, Kwi-Ok 全北大學校 齒醫學硏究所 1985 전북치대논문집 Vol.3 No.1
Catecholamines은 자율신경계 및 중추에서 중요한 신경전도 물질로 작용하는바, 정신신경활동뿐 아니라 신체전반에 걸친 건강상태와 질병에 이들 amine의 대사가 관련되어 있으므로 생체내의 amine 및 대사물을 정확하게 정량하기 위한 방법으로 많은 연구가 진행되어 왔다. 극미량의 amine을 정량하기에 적합한 high performance liquid chromatography (HPLC) 전기화학 분석법의 활용도를 높이고자 연구방법론적인 실험을 시행하여 다음의 결과를 얻었다. 1. 실험과정에 따른 amine 회수율은 alumina 진탕시간 및 용출액의 산도 등에 의하여 다른 값을 나타내었으며, 2. Capacity factor는 mobile phase의 pH, ion-pairing agent의 농도, 및 citrateion 농도등에 의하여 변화를 보였고, 3. 일정 amine 농도에 대한 전기화학 분석기의 반응은 applied potential (vs. Ag/AgCl)의 크기 및 mobile phase의 pH에 따라 큰 값의 차이를 보였다.
A Characterization of the Weak<SUP>*</SUP>-Integral
Rhie, Gil-Seob,Park, Hi-Kyo 충청수학회 1989 충청수학회지 Vol.2 No.1
The main goal of the present paper is to characterize the $weak^*$-integral, which is a $weak^*$ analogy of Geitz[4].
Rhie, Gi Eun,Chung, Gyung Tae,Lee, Yong Jin,Sung, Won Keung,Oh, Hee Bok 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.1
We have earlier reported on the cloning and identification of bft-k from an enterotoxigenic strain of Bacteroides fragilis 419, which was isolated from the blood of a Korean patient who suffered from systemic infections [4, 5]. The bft-k gene encodes a 397-amino-acids metalloprotease enterotoxin, and the protein has been identified as a new isoform of B. fragilis enterotoxins (BFTs), which are cytopathic to intestinal epithelial cells to induce fluid secretion and tissue damage in ligated intestinal loops [4, 6, 18, 20]. This report describes the cloning and sequencing of the enterotoxin pathogenicity islet of B. fragilis 419 which contains the bft-k gene. The cloned enterotoxin pathogenicity islet was found to have 6,045bp in length and to contain 12-bp direct repeats near its end. In the pathogenicity islet, in addition to the BFT-K, two putative open reading frames (ORFs) were identified; (1) the t-3 gene encoding a 396-aminoacids protein of a putative metalloprotease; (2) the third gene encoding an ORF of a 59-amino-acids protein, whose function has not yet been characterized. The expression of the t-3 gene in B. fragilis 419 was verified by western blot analysis.
A Simple GUI-based Sequencing Format Conversion Tool for the Three NGS Platforms
Rhie, A-Rang,Yang, San-Duk,Lee, Kyung-Eun,Thong, Chin Ting,Park, Hyun-Seok Korea Genome Organization 2010 Genomics & informatics Vol.8 No.2
To allow for a quick conversion of the proprietary sequence data from various sequencing platforms, sequence format conversion toolkits are required that can be easily integrated into workflow systems. In this respect, a format conversion tool, as well as quality conversion tool would be the minimum requirements to integrate reads from different platforms. We have developed the Pyrus NGS Sequencing Format Converter, a simple software toolkit which allows to convert three kinds of Next Generation Sequencing reads, into commonly used fasta or fastq formats. The converter modules are all implemented, uniformly, in Java GUI modules that can be integrated in software applications for displaying the data content in the same format.