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Ramí,rez-Lugo, Juan S,Yoo, Hae Yong,Yoon, Su Jin,Dunphy, William G Landes Bioscience 2011 Cell cycle Vol.10 No.3
<P>In the presence of double-stranded DNA breaks (DSBs), the activation of ATR is achieved by the ability of ATM to phosphorylate TopBP1 on serine 1131, which leads to an enhancement of the interaction between ATR and TopBP1. In Xenopus egg extracts, the Mre11-Rad50-Nbs1 (MRN) complex is additionally required to bridge ATM and TopBP1 together. In this report, we show that CtIP, which is recruited to DSB-containing chromatin, interacts with both TopBP1 and Nbs1 in a damage-dependent manner. An N-terminal region containing the first two BRCT repeats of TopBP1 is essential for the interaction with CtIP. Furthermore, two distinct regions in the N-terminus of CtIP participate in establishing the association between CtIP and TopBP1. The first region includes two adjacent putative ATM/ATR phosphorylation sites on serines 273 and 275. Secondly, binding is diminished when an MRN-binding region spanning residues 25-48 is deleted, indicative of a role for the MRN complex in mediating this interaction. This was further evidenced by a decrease in the interaction between CtIP and TopBP1 in Nbs1-depleted extracts and a reciprocal decrease in the binding of Nbs1 to TopBP1 in the absence of CtIP, suggestive of the formation of a complex containing CtIP, TopBP1, and the MRN complex. When CtIP is immunodepleted from egg extracts, the activation of the response to DSBs is compromised and the levels of ATR, TopBP1, and Nbs1 on damaged chromatin are reduced. Thus, CtIP interacts with TopBP1 in a damage-stimulated, MRN-dependent manner during the activation of ATR in response to DSBs.</P>
An, Deokkeun,Ramí,rez, Solange V.,Sellgren, Kris,Arendt, Richard G.,Boogert, A. C. Adwin,Robitaille, Thomas P.,Schultheis, Mathias,Cotera, Angela S.,Smith, Howard A.,Stolovy, Susan R. IOP Publishing 2011 The Astrophysical journal Vol.736 No.2
<P>We present results from our spectroscopic study, using the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope, designed to identify massive young stellar objects (YSOs) in the Galactic center (GC). Our sample of 107 YSO candidates was selected based on Infrared Array Camera (IRAC) colors from the high spatial resolution, high sensitivity Spitzer/IRAC images in the Central Molecular Zone, which spans the central similar to 300 pc region of the Milky Way. We obtained IRS spectra over 5-35 mu m using both high- and low-resolution IRS modules. We spectroscopically identify massive YSOs by the presence of a 15.4 mu m shoulder on the absorption profile of 15 mu m CO2 ice, suggestive of CO2 ice mixed with CH3OH ice on grains. This 15.4 mu m shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We show that nine massive YSOs also reveal molecular gas-phase absorption from CO2, C2H2, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC. We fit YSO models to the observed spectral energy distributions and find YSO masses of 8-23 M-circle dot, which generally agree with the masses derived from observed radio continuum emission. We find that about 50% of photometrically identified YSOs are confirmed with our spectroscopic study. This implies a preliminary star formation rate of similar to 0.07 M-circle dot yr(-1) at the GC.</P>
Cleto Alvarez-Aguilar,Maria Lucia Enrí,quez-Ramí,rez,Benigno Figueroa-Nuñ,ez,Anel Gó,mez-Garcí,a,Ernesto Rodrí,guez-Ayala,Cristina Morá,n-Moguel,Victor Manuel 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.3
Metabolic Syndrome (MS) is recognized as a cluster of cardiovascular risk factors. All components of MS have a genetic base. Genes of the renin angiotensin system are potential candidate genes for MS. We investigated whether angiotensin converting en-zyme (ACE) gene polymorphism increases suscep-tibility to MS as an entity in a Mexican population. In a cross-sectional study, 514 individuals were studied including 245 patients with MS and 269 subjects without MS criteria. ACE gene polymorphism was detected using PCR. MS was defined according to The National Cholesterol Education Program Expert Blood Cholesterol in Adults (Adult Treatment Panel III) criteria, except that the raised fasting plasma glucose ≥100 mg/dl criterion for identification of intolerance fasting glucose was modified in accordance with the suggestion of the American Diabetes Association. Patients with MS were sig - nificantly different from subjects without MS in relation to mean body mass index (BMI), waist circumference (WC), systolic blood pressure, diastolic blood pressure, glucose, total cholesterol (C), triglycerides, HDL-C, and LDL-C (P<0.0001). The differences in the mean BMI, WC, glucose, total cholesterol, triglycerides, LDL-C, and HDL-C were maintained in patients with the MS and DD genotypes (P<0.01). The DD genotype was strongly asso - ciated with MS (adjusted OR = 5.48, 95% CI 3.20-9.38, P<0.0001). We concluded that the DD genotype increases susceptibility to MS in a Mexican pop - ulation. These results indicate that pharmacological and non-pharmacological treatment and a reduction in body fat will have important therapeutic im - plications in this disease.
A multiwavelength analysis of a collection of short-duration GRBs observed between 2012 and 2015
Pandey, S B,Hu, Y,Castro-Tirado, Ao J,Pozanenko, A S,Sá,nchez-Ramí,rez, R,Gorosabel, J,Guziy, S,Jelinek, M,Tello, J C,Jeong, S,Oates, S R,Zhang, B-B,Mazaeva, E D,Volnova, A A,Minaev, P Yu Oxford University Press 2019 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.485 No.4
<B>Abstract</B><P>We investigate the prompt emission and the afterglow properties of short-duration gamma-ray burst (sGRB) 130603B and another eight sGRB events during 2012-2015, observed by several multiwavelength facilities including the Gran Canarias Telescope 10.4 m telescope. Prompt emission high energy data of the events were obtained by INTEGRAL-SPI-ACS, Swift-BAT, and Fermi-GBM satellites. The prompt emission data by INTEGRAL in the energy range of 0.1-10 MeV for sGRB 130603B, sGRB 140606A, sGRB 140930B, sGRB 141212A, and sGRB 151228A do not show any signature of the extended emission or precursor activity and their spectral and temporal properties are similar to those seen in case of other short bursts. For sGRB 130603B, our new afterglow photometric data constrain the pre-jet-break temporal decay due to denser temporal coverage. For sGRB 130603B, the afterglow light curve, containing both our new and previously published photometric data is broadly consistent with the ISM afterglow model. Modeling of the host galaxies of sGRB 130603B and sGRB 141212A using the LePHARE software supports a scenario in which the environment of the burst is undergoing moderate star formation activity. From the inclusion of our late-time data for eight other sGRBs we are able to: place tight constraints on the non-detection of the afterglow, host galaxy, or any underlying ‘kilonova’ emission. Our late-time afterglow observations of the sGRB 170817A/GW170817 are also discussed and compared with the sub-set of sGRBs.</P>
Final report on international comparison CCQM-K74: Nitrogen dioxide, 10 µmol/mol
Flores, Edgar,Idrees, Faraz,Moussay, Philippe,Viallon, Joë,le,Wielgosz, Robert,Ferná,ndez, Teresa,Ramí,rez, Sergio,Rojo, André,s,Shinji, Uehara,Waldé,n, Jari,Sega, Michela Springer-Verlag 2012 METROLOGIA -BERLIN- Vol.49 No.-
<P>There is a high international priority attached to activities which reduce NO<SUB>x</SUB> in the atmosphere. The current level of permitted emissions is typically between 50 µmol/mol and 100 µmol/mol, but lower values are expected in the future. Currently, ambient air quality monitoring regulations also require the measurement of NO<SUB>x</SUB> mole fractions as low as 0.2 µmol/mol. The production of accurate standards at these levels of mole fractions requires either dilution of a stable higher concentration gas standard or production by a dynamic technique, for example one based on permeation tubes.</P><P>The CCQM-K74 key comparison was designed to evaluate the level of comparability of National Metrology Institutes' measurement capabilities and standards for nitrogen dioxide (NO<SUB>2</SUB>) at a nominal mole fraction of 10 µmol/mol.</P><P>The measurements of this key comparison took place from June 2009 to May 2010.</P><P>Seventeen laboratories took part in this comparison coordinated by the BIPM and VSL. The key comparison reference value was based on BIPM measurement results, and the standard measurement uncertainty of the reference value was 0.042 µmol/mol.</P><P>This key comparison demonstrated that the results of the majority of the participants agreed within limits of ±3% relative to the reference value. The results of only one laboratory lay significantly outside these limits. Likewise this comparison made clear that a full interpretation of the results of the comparison needed to take into account the presence of nitric acid (in the range 100 nmol/mol to 350 nmol/mol) in the cylinders circulated as part of the comparison, as well as the possible presence of nitric acid in the primary standards used by participating laboratories.</P><P>Main text.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.</P><P>The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).</P>
The dark nature of GRB 130528A and its host galaxy
Jeong, S.,Castro-Tirado, A. J.,Bremer, M.,Winters, J. M.,Gorosabel, J.,Guziy, S.,Pandey, S. B.,Jelí,nek, M.,Sá,nchez-Ramí,rez, R.,Sokolov, Ilya V.,Orekhova, N. V.,Moskvitin, A. S.,Te Springer-Verlag 2014 Astronomy and astrophysics Vol.569 No.-