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- 저자 : Prabhat Bhusal (검색결과 1 건)
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Application of Carbopol/PVP interpolymer complex to prepare mucoadhesive floating granule
전명관,Prabhat Bhusal,최후균 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
Novel mucoadhesive floating granule was preparedusing Carbopol/PVP interpolymer complex to deliverhydrophilic drugs in a controlled manner. Acetaminophenwas used as a model drug. Maximum floatability of thegranules was obtained at the ratio of 1/1, where 95 % of thegranules floated for 12 h. As the concentration of sodiumbicarbonate increased, both the floating duration and therelease rate of the drug increased. The granules withoutsodium bicarbonate floated only for 2 h and floating onsettime was 15 min. The release rate of drug graduallyincreased as the drug content in the granule increased. Asthe drug content in the granules increased, duration ofadhesion decreased. However, the decrease in adhesionduration was minimal up to 40 % of drug content. Therelease rate from the granules prepared by dry granulationmethod was faster than that by wet granulation. Thegranules prepared by dry granulation method led to formationof highly porous structure; whereas, that by wetgranulation method showed non-porous structure. Theoptimum size of the granules to retard the release of themodel drug was within the range of 3–4 mm. Based onboth mucoadhesive and buoyant properties, the floatinggranules are expected to reside in the upper part of thestomach for sufficient period of time and release the drug ina sustained manner.
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