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- 저자 : Pil Je Park (검색결과 105 건)
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Park Pil Je,Kang Yeon Soo,Jang Hyun Jin,Kim So Jeong,Kim Min Ju,Choi Hyeon Kyu,Jeong Jeong Kyo,Jeon Ju Hyun,Kim Young Il 대한침구의학회 2023 대한침구의학회지 Vol.40 No.4
Bell’s palsy is an acute facial paralysis caused by peripheral facial nerve dysfunction. The aim of this study is to assess the efficacy of Korean medicine in the treatment of three patients who were hospitalized and diagnosed with Bell’s palsy within 2 weeks of coronavirus disease 2019 (COVID-19) infection. The patients were administered with Korean medicine treatments, steroids, and antiviral drugs. Moreover, the Korean medicine treatments include acupuncture, pharmacopuncture, moxibustion, physical therapy, and herbal medicine. Symptom improvement was evaluated daily using the Yanagihara facial nerve grading system, a facial function evaluation tool. Furthermore, it was suggested that the patients affected by Bell’s palsy after COVID-19 infection may have a slower improvement in their treatment progress compared with those without COVID-19 infection in the acute stage.
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Park, Je Seob,Cho, Sung Min,Kim, Woo-Jae,Park, Juhyun,Yoo, Pil J. American Chemical Society 2011 ACS APPLIED MATERIALS & INTERFACES Vol.3 No.2
<P>In this study, we present a facile means of fabricating graphene thin films via layer-by-layer (LbL) assembly of charged graphene nanosheets (GS) based on electrostatic interactions. To this end, graphite oxide (GO) obtained from graphite powder using Hummers method is chemically reduced to carboxylic acid-functionalized GS and amine-functionalized GS to perform an alternate LbL deposition between oppositely charged GSs. Specifically, for successful preparation of positively charged GS, GOs are treated with an intermediate acyl-chlorination reaction by thionyl chloride and a subsequent amidation reaction in pyridine, whereby a stable GO dispersibility can be maintained within the polar reaction solvent. As a result, without the aid of additional hybridization with charged nanomaterials or polyelectrolytes, the oppositely charged graphene nanosheets can be electrostatically assembled to form graphene thin films in an aqueous environment, while obtaining controllability over film thickness and transparency. Finally, the electrical property of the assembled graphene thin films can be enhanced through a thermal treatment process. Notably, the introduction of chloride functions during the acyl-chlorination reaction provides the p-doping effect for the assembled graphene thin films, yielding a sheet resistance of 1.4 kΩ/sq with a light transmittance of 80% after thermal treatment. Since the proposed method allows for large-scale production as well as elaborate manipulation of the physical properties of the graphene thin films, it can be potentially utilized in various applications, such as transparent electrodes, flexible displays and highly sensitive biosensors.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2011/aamick.2011.3.issue-2/am100977p/production/images/medium/am-2010-00977p_0001.gif'></P>
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Je, In-Gyu,Choi, Hyun Gyu,Kim, Hui-Hun,Lee, Soyoung,Choi, Jin Kyeong,Kim, Sung-Wan,Kim, Duk-Sil,Kwon, Taeg Kyu,Shin, Tae-Yong,Park, Pil-Hoon,Khang, Dongwoo,Kim, Sang-Hyun Elsevier 2015 Toxicology and applied pharmacology Vol.287 No.2
<P><B>Abstract</B></P> <P>As the importance of allergic disorders such as atopic dermatitis and allergic asthma, research on potential drug candidates becomes more necessary. Mast cells play an important role as initiators of allergic responses through the release of histamine; therefore, they should be the target of pharmaceutical development for the management of allergic inflammation. In our previous study, anti-allergic effect of extracts of <I>Amomum xanthioides</I> was demonstrated. To further investigate improved candidates, 1,2,4,5-tetramethoxybenzene (TMB) was isolated from methanol extracts of <I>A. xanthioides</I>. TMB dose-dependently attenuated the degranulation of mast cells without cytotoxicity by inhibiting calcium influx. TMB decreased the expression of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-4 at both the transcriptional and translational levels. Increased expression of these cytokines was caused by translocation of nuclear factor-κB into the nucleus, and it was hindered by suppressing activation of IκB kinase complex. To confirm the effect of TMB <I>in vivo</I>, the ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) models were used. In the ASA model, hypothermia was decreased by oral administration of TMB, which attenuated serum histamine, OVA-specific IgE, and IL-4 levels. Increased pigmentation of Evans blue was reduced by TMB in a dose-dependent manner in the PCA model. Our results suggest that TMB is a possible therapeutic candidate for allergic inflammatory diseases that acts through the inhibition of mast cell degranulation and expression of pro-inflammatory cytokines.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TMB reduced the degranulation of mast cells. </LI> <LI> TMB inhibited the production of pro-inflammatory cytokines. </LI> <LI> TMB suppressed both active and passive anaphylaxis. </LI> <LI> Anti-allergic inflammatory effects of TMB might be due to the blocking IKK complex. </LI> <LI> TMB might be a candidate for the treatment of allergic inflammatory diseases. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Park Seong Je,Choi Joon Phil,Lee Pil-Ho,Moon Seung Ki 한국CDE학회 2025 Journal of computational design and engineering Vol.12 No.4
Metal–polymer hybrid structures (MPHS) have been widely used in various industrial fields due to MPHS's ability to combine the advantages of metals and polymers. Herein, we investigate the applications of computer-aided engineering to predict and optimize the joint performance of MPHS while reducing time and material costs in the design phase. The objective of this study is to propose a methodology for evaluating joint stability and designing a lattice structure for the high joints of MPHS using finite-element analysis (FEA). The proposed methodology consists of six steps, including 3D modelling, material assignment, boundary condition setup, and stress analysis using FEA. The proposed methodology's applicability is verified using octet-truss (OT) and body-centred cubic (BCC) in the interfaces between a metal and a polymer. In addition, the generalization of the proposed methodology is demonstrated by applying various materials to metal-with-lattice-structure (latticed metal) and polymer. Finally, based on the results of FEA, we propose a new design of lattice structures for high-joint performance in terms of joint stability and lightweight. The proposed ring-based lattice structures especially show relatively excellent joint performance compared to the OT and BCC. The proposed methodology can be leveraged to effectively verify and optimize designs without developing a physical prototype of the MPHS, thereby providing reliable guidance.
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삼일엽 원충(Plasmodium vivax)감염에 의한 부정맥 및 심막 삼출액 발생 1예
유제성,이진희,정성필,구홍두,박인철 대한감염학회 2006 감염과 화학요법 Vol.38 No.6
말라리아에 감염되었을 경우, 고열 외에 뇌형 말라리아, 급성신부전, 급성 폐부종, 저혈당, 세균성 감염 등의 합병증을 유발하는 것으로 알려져 있다. 드물지만, 외국에서는 열대열 원충에 의해 부정맥이나 심막 삼출액 등과 같은 심장 질환이 발생한 보고도 있다. 하지만 본 예와 같이 삼일열 원충에 의해서도 서맥, 2도, 3도 방실결절 차단의 부정맥과 심막 삼출액 발생할 수도 있다. 말라리아가 빈발하는 지역에서 이런 증상의 환자를 발견하는 경우, 반드시 말라리아 감염을 의심하고, 적절한 진단 및 치료가 이루어지도록 해야 할 것이다. 저자들은 삼일열 원충에 의해 부정맥 및 심막 삼출액이 발생한 환자 1예를 경험하였기에 보고하였다. Plasmodium vivax is a typically seen infectious disease in Korea. The incidence of Plasmodium vivax malaria has been increasing in recent year despite of worldwide attempts at control. Fever, anemia, thrombocytopenia, and splenomegaly are the most common manifestations seen in Korean patient with P. vivax. Cardiac involvement is thought to be a very rare complication of malaria infection. Cardiac complication seems to be limited to acute infection with Plasmodium falcifarum. However we have experienced cardiac complication such as pericardial effusion, and complete AV block by Plasmodium vivax. Physicians should consider cardiac involvement in patient who present hypotension, fever and arrhythmia in malaria endemic area.
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