해양 미세조류 Isochrysis galbana Parke로부터 EPA와 DHA의 생산

오유관(You-Kwan Oh),김유진(Yu-Jin Kim),박성훈(Sunghoon Park) 한국생물공학회 1997 KSBB Journal Vol.12 No.3

초음파 센서를 이용한 차량 주차공간 탐색에서의 연석 감지 알고리즘

김수용(Suyong Kim),이동욱(Dongwook Lee),박성훈(Sunghoon Park),권재희(Jaehee Kwon) 한국자동차공학회 2011 한국자동차공학회 학술대회 및 전시회 Vol.2011 No.11

Recently many automobile companies are developing parking assist system as it improves the convenience of drivers. Among several types of parking assistance system, the method using ultrasonic sensors for detecting parking space is widely used because of its low cost and usefulness. In order to detect the parking space, the parking space detection algorithm provides the width and the length of the parking space using long range ultrasonic sensor. In this paper, to detect the accurate parking space with the curbstone, the curbstone detection algorithm is proposed. The performances of the proposed algorithm are verified and evaluated by experiments.

무인 자율주차 시스템 구현을 위한 기반기술 연구

전재한(Jaehan Jeon),최아라(Ara Choi),박성훈(Sunghoon Park),정태영(Taeyoung Chung) 한국자동차공학회 2014 한국자동차공학회 학술대회 및 전시회 Vol.2014 No.11

As an autonomous driving technology is the future of on-road driving, an unmanned valet parking system is one of a key technology to realize door to door autonomous vehicle. When an autonomous vehicle arrive its destination, the driver steps out of the car and pushes button on the smart phone, and then the vehicle autonomously parking in without any anxiety of user. Similarly, the vehicle gets out from the parking lot at right time and right position for user. We mainly focused on a vehicle actuator control, path following control for parking slot detection, parking maneuver control with shift-by-wire system, and smart phone interface between the user and vehicle. As the localization technology of a vehicle at the indoor or outdoor parking areas is most important and difficult problem, we applied precise position information from the DGPS for preliminary implementation of the system.

In Vitro Antimicrobial Susceptibility of <i>Mycobacterium abscessus</i> in Korea

Park, Sunghoon,Kim, Shinok,Park, Eun Mi,Kim, Hojoong,Kwon, O Jung,Chang, Chulhun L.,Lew, Woo Jin,Park, Young Kil,Koh, Won-Jung The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.1

<P><I>Mycobacterium abscessus</I> is the second most common etiology of pulmonary disease caused by nontuberculous mycobacteria in Korea. Although antimicrobial susceptibility tests are important for appropriate patient management in <I>M. abscessus</I> lung disease, the tests have never been investigated in Korea. Seventy-four isolates of <I>M. abscessus</I> recovered from patient respiratory samples were tested against eight antimicrobial agents following the guidelines set forth by the National Committee for Clinical Laboratory Standards. Of the parenteral antibiotics, amikacin (99%, 73/74) and cefoxitin (99%, 73/74) were active against most isolates. Imipenem (55%, 36/66) and tobramycin (36%, 27/74) had activity against moderate number of isolates. Of the oral antibiotics, clarithromycin (91%, 67/74) was active against the majority of isolates. Moxifloxacin (73%, 54/74) and ciprofloxacin (57%, 42/74) had activity against a moderate number of isolates. Doxycycline was the least active, inhibiting only 7% (5/74) of isolates. In conclusion, the variations in susceptibility within <I>M. abscessus</I> isolates to currently available antimicrobials suggest that the antimicrobial susceptibilities of any clinically significant <I>M. abscessus</I> isolate be needed individually.</P>

A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study

Park, Sunghoon,Lee, Myung-Gu,Lee, Kwan Ho,Park, Yong Bum,Yoo, Kwang Ha,Park, Jeong-Woong,Kim, Changhwan,Lee, Yong Chul,Park, Jae Seuk,Kwon, Yong Soo,Seo, Ki-Hyun,Kim, Hui Jung,Kwak, Seung Min,Kim, Ju- The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.73 No.5

Background: Limited data on the incidence and clinical characteristics of adult pertussis infections are available in Korea. Methods: Thirty-one hospitals and the Korean Centers for Disease Control and Prevention collaborated to investigate the incidence and clinical characteristics of pertussis infections among adults with a bothersome cough in non-outbreak, ordinary outpatient settings. Nasopharyngeal aspirates or nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and culture tests. Results: The study enrolled 934 patients between September 2009 and April 2011. Five patients were diagnosed as confirmed cases, satisfying both clinical and laboratory criteria (five positive PCR and one concurrent positive culture). Among 607 patients with cough duration of at least 2 weeks, 504 satisfied the clinical criteria of the US Centers for Disease Control and Prevention (i.e., probable case). The clinical pertussis cases (i.e., both probable and confirmed cases) had a wide age distribution ($45.7{\pm}15.5$ years) and cough duration (median, 30 days; interquartile range, 18.0~50.0 days). In addition, sputum, rhinorrhea, and myalgia were less common and dyspnea was more common in the clinical cases, compared to the others (p=0.037, p=0.006, p=0.005, and p=0.030, respectively). Conclusion: The positive rate of pertussis infection may be low in non-outbreak, ordinary clinical settings if a PCR-based method is used. However, further prospective, well-designed, multicenter studies are needed.

Clinical significance of <i>Mycobacterium fortuitum</i> isolated from respiratory specimens

Park, Sunghoon,Suh, Gee Young,Chung, Man Pyo,Kim, Hojoong,Kwon, O. Jung,Lee, Kyung Soo,Lee, Nam Yong,Koh, Won-Jung Elsevier 2008 Respiratory medicine Vol.102 No.3

<P><B>Summary</B></P><P><B>Background</B></P><P>Although <I>Mycobacterium fortuitum</I> is not an uncommon organism among the non-tuberculous mycobacteria isolated from respiratory specimens, its clinical significance had not been well studied.</P><P><B>Methods</B></P><P>We identified all patients whose respiratory specimens were positive for <I>M. fortuitum</I> between January 2003 and December 2005. Among 182 patients whose specimens were positive for <I>M. fortuitum</I>, 26 were positive at least twice. We retrospectively reviewed their characteristics, and clinical courses.</P><P><B>Results</B></P><P>Of the 26 patients, 15 had two positive culture results for <I>M. fortuitum</I>; the other 11 had three or more. Sixteen patients were male and the median age was 61.5 years. Major presenting symptoms were cough (65%) and sputum (58%). Most patients had known underlying lung diseases, including prior tuberculosis (54%), lung cancer (15%), idiopathic pulmonary fibrosis (15%), and other mycobacterial lung disease (15%). The most common CT findings were bronchiectasis (80%). Only one patient received specific prolonged antibiotic therapy against <I>M. fortuitum</I> infection; the other 25 did not. No patients showed clinical aggravation during the follow-up period, although in five patients their underlying lung diseases continued to progress. The median follow-up duration was 12.5 months and none of the patients whose sputum specimens were available had persistent positive cultures for <I>M. fortuitum</I>.</P><P><B>Conclusion</B></P><P><I>M. fortuitum</I> usually causes colonization or transient infection in patients with underlying lung disease, such as prior tuberculosis or bronchiectasis. The majority of patients may not need to receive prolonged antibiotic therapy for <I>M. fortuitum</I> isolates.</P>

Room-Temperature Hydrogen Gas Sensing Properties of the Networked Cr2O3-Functionalized Nb2O5 Nanostructured Sensor

Sunghoon Park,Hyejoon Kheel,Gun-Joo Sun,Hyoun Woo Kim,Taegyung Ko,Chongmu Lee 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.4

Cr2O3-functionalized Nb2O5 nanoparticles were synthesized via a facile hydrothermal route. The multiple-networked Cr2O3-functionalized Nb2O5 nanostructured sensor showed enhanced H2 gas sensing performance compared to its pristine Nb2O5 nanostructure counterpart. The Cr2O3-functionalized Nb2O5 nanostructure sensor showed responses of 5.24 to 2 ppm of H2 at room temperature, whereas the pristine Nb2O5 nanoparticle sensors showed responses of 2.29. The former also exhibited a faster response to H2. The multiple-networked pristine and Cr2O3-functionalized Nb2O5 nanostructured sensors were stronger and much shorter, respectively, than other nanomaterial-based Schottky diode-type sensors and Nb2O5-based Schottky diode-type sensors. The underlying mechanism for the enhanced sensing performance of the Cr2O3-functionalized Nb2O5 nanostructured sensor towards H2 gas is discussed in detail. Particular emphasis is placed on the role of the Cr2O3-Nb2O5 p-n junction in the Cr2O3-functionalized Nb2O5 nanostructure sensor.

UV-activated gas sensing properties of ZnS nanorods functionalized with Pd

Park, Sunghoon,An, Soyeon,Mun, Youngho,Lee, Chongmu Elsevier 2014 CURRENT APPLIED PHYSICS Vol.14 No.1

Pd-functionalized ZnS nanorods were prepared for use as gas sensors. Scanning electron microscopy revealed the diameters and lengths of the nanorods ranging from 30 to 80 nm and from 2 to 5 mu m, respectively. The diameter of Pd nanoparticles ranged from 2 to 5 nm. Transmission electron microscopy revealed that ZnS nanorods and Pd nanoparticles were monocrystalline and amorphous, respectively. The responses of multiple networked ZnS nanorods sensors to 1-5 ppm NO2 were increased substantially by a combination of Pd functionalization and UV irradiation. Pristine ZnS nanorod sensors at room temperature in the dark showed a response (similar to 100%) almost independent of NO2 concentration in a NO2 concentration range of 1-5 ppm. Pristine ZnS nanorod sensors showed enhanced responses of 214-603% to 1-5 ppm NO2 at room temperature under UV illumination. Pd-functionalized ZnS nanorods sensors showed further enhanced responses of 355-1511% to 1-5 ppm NO2 at room temperature under UV illumination. The NO2 gas sensing mechanism of the Pd-functionalized ZnS nanorods sensors under UV illumination is discussed in depth. (C) 2013 Elsevier B.V. All rights reserved.

Sorting directionally oriented microstructures using railed microfluidics

Park, Wook,Lee, Hosuk,Park, Hyungsung,Kwon, Sunghoon Royal Society of Chemistry 2009 Lab on a chip Vol.9 No.15

<P>We demonstrate the microfluidic sorting of directionally oriented (anisotropic) microstructures by their orientational state in solution using the concept of railed microfluidics. After being injected into a microfluidic channel, the microstructures rotate and flip in various directions. In order to sort microstructures in an organized way, we designed the microstructures and the microchannel to allow for orientation-based control of microstructure movement. In order to sort microstructures based on their rotation, we used a wedge shaped fin on the microstructures and a Y-shaped railed microfluidic channel. For sorting flipped particles, we use a double-railed microfluidic channel that has grooves on both its top and bottom surfaces. By integrating the two sorting methods we demonstrated high throughput, autonomous sorting into four different orientational states: unrotated–unflipped, rotated–unflipped, unrotated–flipped, and rotated–flipped. Here we not only demonstrate orientational assembly of directionally dependent microstructures, but also present design considerations for future work.</P> <P>Graphic Abstract</P><P>Autonomous microfluidic sorting technique for directionally oriented (anisotropic) microstructures by their orientation state (flipped and unflipped, rotated and unrotated) using the wedged fin and Y-shaped rail, and double rail concepts <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b904153b'> </P>

AIMP3 Haploinsufficiency Disrupts Oncogene-Induced p53 Activation and Genomic Stability

Park, Bum-Joon,Oh, Young Sun,Park, Seung Yong,Choi, So Jung,Rudolph, Cornelia,Schlegelberger, Brigitte,Kim, Sunghoon American Association for Cancer Research 2006 Cancer Research Vol.66 No.14

<P>AIMP3 (previously known as p18) was shown to up-regulate p53 in response to DNA damage. Here, we show that AIMP3 couples oncogenic stresses to p53 activation to prevent cell transformation. Growth factor- or Ras-dependent induction of p53 was blocked by single allelic loss of AIMP3 as well as by suppression of AIMP3. AIMP3 heterozygous cells became susceptible to cell transformation induced by oncogenes such as Ras or Myc alone. The transformed AIMP3+/- cells showed severe abnormality in cell division and chromosomal structure. Thus, AIMP3 plays crucial roles in p53-mediated tumor-suppressive response against oncogenic stresses via differential activation of ATM and ATR, and in the maintenance of genomic stability.</P>