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Influence of Al2O3 Content and Cooling Rate on Crystallization in Fe2O3–CaO–SiO2–Al2O3 Systems
Tae Jun Park,Joon Sung Choi,Dong Joon Min 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9
The behavior of silico-ferrite of calcium and aluminum (SFCA) phases and the influence of sintered ore quality were investigatedusing a confocal laser scanning microscope to understand how the Al2O3content of iron ore affects the sintered orestructure and the crystallization behavior of SFCA in a Fe2O3–CaO–Al2O3–SiO2 pseudo-quaternary system. The experimentalresults were used to inform simulations of the heterogeneous dynamic behavior in response to the rapid temperature changesand various chemical compositions typically encountered in actual sintering processes. Increasing the Al2O3content in theFe2O3–CaO–Al2O3–SiO2 pseudo-quaternary system led to the hematite content decreasing, which affects the reducibilityof the sintered ore. The correlation between the creation of SFCA and the cooling effect associated with varying the Al2O3is discussed in detail.
Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6
<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>
LNT를 통해 분석한 국립공원 탐방목적과 산행 윤리 의식의 상관성 : 내장산국립공원 백양사지구와 남창지구를 중심으로
최형철(Choi Hyung Chul),박재철(Park Jae Chul),노재현(Roh Jae Hyun),신상섭(Shin Sang Sup),허준(Huh Joon) 한국산림휴양학회 2010 한국산림휴양학회지 Vol.14 No.3
본 연구는 LNT 항목의 분석을 통해서 산행 목적과 산행윤리의식 사이의 차이를 규명하기 위하여 수행되었다. 이를 위해서, 내장산국립공원의 백양사지구와 남창지구를 사례로 연구를 수행하였다. 이를 통해 국립공원 방문목적에 따라서 윤리 의식이 유의한 차이가 있음을 확인할 수 있었다. 다시 말하면, 산행목적의 탐방객이 행락 목적의 탐방객보다 윤리 의식이 높은 것을 확인할 수 있었다. This study was performed to identify the difference between purpose and ethics consciousness of national park visit through analysis of LNT(Leave No Trace) items. For this, case study was performed in the Baekyangsa and Namchang district in Naejang national park. Study methods were questionnaire and statistic analyses. Through these, the difference of Ethics Consciousness of national park visit according to visit purpose of one was identified. In other words, it was identified that visitors for climbing purpose had higher than those for pleasure-making in Ethics Consciousness of National Park Visit.
임준범 ( Joon Bum Lim ),이수범 ( Soo Beom Lee ),성정곤 ( Jung Gon Sung ),박준태 ( Jun Tae Park ) 한국안전학회(구 한국산업안전학회) 2012 한국안전학회지 Vol.27 No.4
This research has analyzed factors affecting customers` satisfaction when they use parking lots of big retailers so that, in case of constructing, operating or managing such retailers, proper measures can be come up with. The analysis has been implemented on the basis of survey, and influence factors including entry/exit lamp, parking cars`` traffic flow, parking type, pedestrians`` movement after parking and safety. Parking lot users`` satisfaction has been analyzed by using the Structural Equation Modelling and, as a result of it, in case of a detached or single building, pedestrians movement flow after parking contributed the most to the users`` satisfaction, while, in case of multipurpose complex, parking cars traffic flow has the most influential factor. It is interpreted that users of a single building put a bigger emphasis on entry to the shop and their way back to the parked area after their shopping while customers of multipurpose complex might have various purposes of visiting the place and there are relatively more cars so that they put more emphasis on traffic counterflow, other cars and pedestrians.
Overexpression of Neuron-Specific Enolase as a Prognostic Factor in Patients with Gastric Cancer
Park, Taejin,Lee, Young-Joon,Jeong, Sang-Ho,Choi, Sang-Kyung,Jung, Eun-Jung,Ju, Young-tae,Jeong, Chi-Young,Park, Miyeong,Hah, Young-Sool,Yoo, Jiyun,Ha, Woo-Song,Hong, Soon-Chan,Ko, Gyung Hyuck The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.3
Purpose: Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC). Materials and Methods: To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens. Cytoplasmic NSE expression was scored from 0 to 4, reflecting the percentage of NSE-positive cells. Results: In terms of histology as per the World Health Organization criteria (P=0.34), there were no differences between the NSE overexpression (NSE-OE) and NSE underexpression (NSE-UE) groups. The NSE-OE group showed a significantly lower rate of advanced GC (P<0.01), lymph node metastasis (P=0.01), advanced stage group (P<0.01), cancer-related death (P<0.01), and cancer recurrence (P<0.01). Additionally, a Kaplan-Meier survival analysis revealed that the NSE-OE group had longer cumulative survival times than the NSE-UE group (log-rank test, P<0.01). However, there were no significant differences in the serum levels of NSE expression in patients with GC and healthy volunteers (P=0.28). Conclusions: Patients with NSE overexpressing GC tissues showed better prognostic results, implying that NSE could be a candidate biomarker of GC.
( Sang Il Choi ),( Joong-won Park ),( Bo Hyun Kim ),( Ju Hee Lee ),( Seung Duk Lee ),( In Joon Lee ),( Tae Hyun Kim ),( Seong Hoon Kim ),( Young Hwan Koh ),( Hyun Beom Kim ),( Eun Kyung Hong ),( Chang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In South Korea, an endemic area of hepatitis B virus (HBV), the incidence and mortality of HCC is gradually decreasing by HBV vaccination, antiviral treatment, early tumor detection, improved treatment options, and evidence-based guidelines. This study investigated the changes over time in the baseline characteristics and clinical outcomes of HCC patients at a single center. Methods: Patients initially diagnosed with and treated for HCC at the National Cancer Center between 2000 and 2015 (n=4291) were followed-up until February 2017. Difference in patient characteristics and outcomes were compared in patients diagnosed in 2000-2004 (n=1157), 2005-2009 (n=1678), and 2010-2015 (n=1456). Results: The median age of the patient cohort was 57 years (range 13-98) years, and most were male (3502, 81.6%). HBV infection was the most common etiology (74.7%). The percentage of patients with Child class A (69.1%, 79.9%, and 87.1%, respectively) and BCLC stage 0 (4.1%, 5.2%, and 9.8%, respectively) increased significantly over time. Median overall survival also increased significantly over time, from 14.4 months (95% confidence interval [CI] 12.0-16.8 months) in 2000-2004, to 22.9 months (95% CI, 20.3-25.5 months) in 2005-2009, to 53.6 months (95% CI, 45.7- 61.5 months) in 2010-2015 (p<0.001). OS of patients with modified UICC stage IV (3.6 vs. 4.7 vs 6.1 months, p<0.001) and with HBV etiology (12.7 vs 20.4 vs 64.5 months, p<0.001) was observed in patients diagnosed in 2000-2004, 2005-2009 and 2010-2015, respectively. Conclusions: Survival of patients with HCC has improved significantly over time in a single center in South Korea. Analysis is ongoing to determine the causes of the improved outcomes.
One Sister and Brother with Mirror Image Myopic Anisometropia
Sung Joon Park,Joo Yeon Kim,Seung Hee Baek,Eung Suk Kim,Ung Soo S. Kim 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.1
We report a case of one sister and brother with mirror image myopic anisometropia. One sister and brother complained visual disturbance. The sister was 10 years 11 months old, and brother was 8 years 4 months old. Full ophthalmic examinations were performed, including slit lamp examination, intraocular pressure, keratometry, anterior chamber depth, axial length, fundus examination and the cycloplegic refraction. The cycloplegic refractive power was -15.50 dpt cyl.+4.50 dpt Ax 85° (right eye), -1.00 dpt cyl.+0.50 dpt Ax 90° (left eye) in the sister; -1.75 dpt cyl.+2.25 dpt Ax 90° (right eye), -9.50 dpt cyl.+4.00 dpt Ax 80° (left eye) in the brother. The co-occurrence of severe myopic anisometropia in a sister and brother is extremely rare. The present case suggests that severe myopic anisometropia may be related by genetic inheritance.