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- 검색키워드
- 저자 : Olkkonen, Vesa M. (검색결과 2 건)
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Ingegerd Forsskahl,Carla Olkkonen,Henrik Tylli 한국펄프·종이공학회 1999 한국펄프종이학회 기타 간행물 Vol.- No.-
Different papers such as toilet and towel tissue, newsprint and copy paper made from reclaimed fibres were characterized using UV-VIS reflectance and fluorescence spectroscopy. The emission properties of the extracts of the papers were also evaluated. Photochemical irradiation at ambient temperatures, and thermal aging of the copy papers at 105℃ and 150℃ were performed. Post-colour numbers (PC) were calculated from the reflectance values measured from the corresponding UV -VIS reflectance spectra. Light absorption coefficient spectra were calculated before and after irradiation, and the changes in absorption coefficient were related to the content of chromophores in the papers. Photochemical and thermal discolouration of the copy papers, similar to that of virgin fibres, was readily observed. The influence of changes in the concentrations of fluorescent brightening agents and dyes on the spectral properties was also assessed. Photostabilization studies of the copy papers were performed with the use of polymer additives polyethylene glycol (PEG) and polytetrahydrofuran (PTHF).
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Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307
Albulescu, Lucian,Bigay, Joë,lle,Biswas, Bishyajit,Weber-Boyvat, Marion,Dorobantu, Cristina M.,Delang, Leen,van der Schaar, Hilde M.,Jung, Young-Sik,Neyts, Johan,Olkkonen, Vesa M.,van Kuppeveld, F Elsevier 2017 ANTIVIRAL RESEARCH Vol.140 No.-
<P>The genus Enterovirus (e.g. poliovirus, coxsackievirus, rhinovirus) of the Picornaviridae family of positive strand RNA viruses includes many important pathogens linked to a range of acute and chronic diseases for which no approved antiviral therapy is available. Targeting a step in the life cycle that is highly conserved provides an attractive strategy for developing broad-range inhibitors of enterovirus infection. A step that is currently explored as a target for the development of antivirals is the formation of replication organelles, which support replication of the viral genome. To build replication organelles, enteroviruses rewire cellular machinery and hijack lipid homeostasis pathways. For example, enteroviruses exploit the PI4KIIII beta-PI4P-OSBP pathway to direct cholesterol to replication organelles. Here, we uncover that TTP-8307, a known enterovirus replication inhibitor, acts through the PI4KIIII-PI4P-OSBP pathway by directly inhibiting OSBP activity. However, despite a shared mechanism of 1TP-8307 with established OSBP inhibitors (itraconazole and OSW-1), we identify a number of notable differences between these compounds. The antiviral activity of TTP-8307 extends to other viruses that require OSBP, namely the picornavirus encephalomyocarditis virus and the flavivirus hepatitis C virus. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license</P>
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