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Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
ROBUST TRAFFIC LIGHT DETECTION AND CLASSIFICATION UNDER DAY AND NIGHT CONDITIONS
Phuc Manh Nguyen,Vu Cong Nguyen,Son Ngoc Nguyen,Linh My Thi Dang,Ha Xuan Nguyen,Vinh Dinh Nguyen 제어로봇시스템학회 2020 제어로봇시스템학회 국제학술대회 논문집 Vol.2020 No.10
Recently, traffic light detection and classification systems have been studied and developed to build an autonomous car by many research institutes, universities, and companies. However, the results of existing traffic light detection systems are still not stable under day and night conditions. It is difficult to detect the location of traffic light due to their small size. Moreover, traffic lights’ shapes are also similar to advertisement lights in a city road. Therefore, this paper proposed a new approach to improve the performance of existing traffic light detection systems by using the benefits of hand-crafted features and deep learning techniques. Experimental results show that the proposed system obtained the detection rate of 80% under night conditions, while the color-based density method only got the detection rate of 50.43% under night conditions.
A risk analysis of step-down equity-linked securities based on regime-switching copula
Nguyen, Manh Duc,Ko, Bangwon,Kwon, Hyuk-Sung The Korean Statistical Society 2020 Communications for statistical applications and me Vol.27 No.1
The globalization of financial markets has broadened investment opportunities. International investors' investment portfolios consist of financial instruments from various countries; consequently, the risks associated with economic dependence among countries should be carefully considered. Step-down equity-linked securities (ELS) are a structured financial product that have recently become popular among Korean investors. Payoffs are based on two or three stock indices from different regions; therefore, dependence between the indices should be reflected in the risk analysis. In this study, we consider a regime-switching copula model to describe the joint behavior of two stock indices- the Eurostoxx50 and the Hang Seng China Enterprises Index (HSCEI). These indices are commonly used as underlying assets of step-down ELS. Using historical data, we analyze the risk associated with step-down ELS through the probabilities of early redemption. A regime-switching copula model can accommodate complicated dependence. Thus, it should be considered in the risk analysis of step-down ELS.
An Optimal Market Clearing Algorithm for Peer-to-Peer Energy Trading in Smart Grid
Nguyen Manh Hung,Hyo-Sung Ahn 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
Energy trading problem in electricity market is one of the emerging concepts in smart grid. Peer-to-peer (P2P) trading is one of the promising approaches for designing decentralized mechanism. In P2P trading approach, each player in the network connects and exchanges power or energy directedly with a set of trading neighbours. In this work, we introduce a new optimal clearing problem for P2P energy market. Next, we present a decentralized algorithm using Alternating Direction Method of Multipliers (ADMM) to maximize the total welfare of the whole community and also reach the supply-demand balance. Lastly, a pricing mechanism will be provided to choose the appropriate prices for all trading pairs such that sellers and buyers are both satisfied.
Resource Allocation for Epidemic Network under Complications
Nguyen Manh Hung,Quoc Van Tran,Ji Liu,Hyo-Sung Ahn 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
In this work, we study the optimal resource allocation to control an epidemic outbreak in a network of population. In particular, we utilize a Susceptible-Infected-Complicated-Susceptible (SICS) model in which complication phenomena is considered. Due to the limitation of the resources, the epidemic is modelled with two levels of recovery rate: one associated with people under medical treatment and the other associated with people who can get rid of the disease by themselves. The resource allocation is considered in these two cases as well. The problem is formulated as a Geometric Program with budget constraint and rate constraint. We illustrate the performance of our approach through numerical simulations.
The Determinants of Citizens' Satisfaction of E-Government: An Empirical Study in Vietnam
NGUYEN, Thuy Thu,PHAN, Duc Manh,LE, Anh Ha,NGUYEN, Lan Thi Ngoc Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.8
This research aims to identify the determinants of e-government satisfaction in Hanoi, Vietnam, and assess their impact. To collect data, we conducted an online questionnaire with citizens living in Hanoi in a time span of five weeks. We received 1,107 responses, divided into three groups: unaware, known, but not used, and used e-government. After leveraging past studies on satisfaction in different contexts, we arrived at six external variables that are of particular relevance to e-government satisfaction (i.e., efficiency, trust, reliability, convenience, citizen support, and transparency) as well as four control variables (i.e., age, gender, education level, and Internet frequency). We then applied both SPSS 22 and STATA 2016 to process and analyze the collected data and found that, while almost all external variables are statistically significant, all four control variables are not. Apart from convenience and trust, four factors - efficiency, reliability, citizens support, transparency - are important measures of system quality, information quality, service quality and relative benefits of e-government, which in turn positively and significantly impact citizens' satisfaction with the online public services. Furthermore, the efficiency variable has the most influence on customer satisfaction, and the level of impact on the dependent variable decreases in the following order: citizen support, reliability and transparency.
Nguyen, Manh-Cuong,On, Nuri,Ji, Hyungmin,Nguyen, An Hoang-Thuy,Choi, Sujin,Cheon, Jonggyu,Yu, Kyoung-Moon,Cho, Seong-Yong,Kim, JinHyun,Kim, Sangwoo,Jeong, Jaekyeong,Choi, Rino Institute of Electrical and Electronics Engineers 2018 IEEE transactions on electron devices Vol.65 No.6
<P>The self-heating effect (SHE) in top-gate In–Ga–Zn–O (IGZO) thin-film transistors (TFTs) was examined systematically using short electrical pulse measurement methods. The temperature dependence of the pulse measurements of IGZO TFTs revealed a significant increase in temperature during the measurements, suggesting that conventional measurements can overestimate the device performance significantly. The effective temperature was introduced and extracted for IGZO TFTs at various heating powers and ambient temperatures. The short sampling time was determined to be a key in characterizing the intrinsic device properties that are not influenced by the SHE. The cooling behavior after self-heating was also examined using multipulse measurements. Because heating and cooling are significant even in a very short time, it is essential to consider the operation condition of the devices when characterizing TFTs to estimate the precise performance and reliability in a real operation.</P>
Nguyen, Manh Hung,Jeong, Haechang,Jhang, Sung-su,Kim, Bu-gi,Yang, Changjo The Korean Society of Marine Environment and safet 2016 海洋環境安全學會誌 Vol.22 No.3
In this paper, a numerical experiment on a tidal turbine was performed based on a water wheel design using the commercial CFD code ANSYS-CFX to contribute to the development of water wheels. The water wheel type tidal turbine was studied with different numbers of rotor blades (including ten, twelve and twenty blades types) and with different blade shapes (Straight, Curved and Zuppinger types) for comparison at several values of tip speed ratio (TSR) ranging from 0.7 to 1.2. The numerical results indicated that the 10-bladed type and the Straight-bladed type turbines absorb the highest power efficiency, up to 43 % at TSR 0.9. In addition, the 20-bladed and the Curved-bladed types showed the lowest performances in all cases of TSRs comparing with the others. Besides that, it was found that this turbine operates much effectively at low range of TSR, especially at TSRs 0.9 and 1 for all cases of blade shapes and all numbers of blades.
Nonlinearity response correction in phase-shifting deflectometry
Nguyen, Manh The,Kang, Pilseong,Ghim, Young-Sik,Rhee, Hyug-Gyo IOP Pub 2018 Measurement science & technology Vol.29 No.4
<P>Owing to the nonlinearity response of digital devices such as screens and cameras in phase-shifting deflectometry, non-sinusoidal phase-shifted fringe patterns are generated and additional measurement errors are introduced. In this paper, a new deflectometry technique is described for overcoming these problems using a pre-distorted pattern combined with an advanced iterative algorithm. The experiment results show that this method can reconstruct the 3D surface map of a sample without fringe print-through caused by the nonlinearity response of digital devices. The proposed technique is verified by measuring the surface height variations in a deformable mirror and comparing them with the measurement result obtained using a coordinate measuring machine. The difference between the two measurement results is estimated to be less than 13 <I>µ</I>m.</P>