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Spectrum of Lysosomal Storage Disease Targeted for Newborn Screening in Vietnam
Dung, Vu Chi,Ngoc, Can Thi Bich,Khanh, Nguyen Ngoc,Mai, Do Thi Thanh,Thao, Bui Phuong,Mai, Tran Thi Chi,Ha, Nguyen Thu,Huong, Nguyen Thi Mai,Nam, Nguyen Hoang,Hai, Le Thanh,Tomatsu, Shunji,Yoo, Han-Wo Association for Research of MPS and Rare Diseases 2017 Journal of mucopolysaccharidosis and rare disease Vol.3 No.1
Nguyen Thu Hang,Nguyen Mai Chi,Nguyen Hoang Trung,Thi Y Van Tran,Vu Ngoc Trung,Thu Hang Bui,Duc Trinh Chu,Bui Tung Thanh,Jen Chun-Ping,Quang Loc Do 한국농업기계학회 2024 바이오시스템공학 Vol.49 No.1
Purpose Circulating tumor cell separation and analysis have played a critical role in cancer diagnosis, prognosis, and treatment. In this work, we aim to design and investigate a novel biochip that integrates dielectrophoresis, microfl uidic technology to separate circulating tumor cells from blood cells. To create a dielectrophoresis-induced non-uniform electric fi eld, a facing-electrode design was proposed and utilized, in which a slanted electrode array and a simple rectangular ground electrode are placed parallel on the top and bottom parts of the microfl uidic channel, respectively. This design can reduce the particle position dependence in the microchannel and the complexity of the microfabrication process. Methods The separation process, effi ciency, and optimization of the proposed device were numerically investigated using the fi nite element method. Parametric research was conducted to comprehensively examine the impact of various operating and design factors on the cell movement and trajectories in the microfl uidic device. Results The results indicated the potential of the proposed biochip to ensure cancer cell separation from blood cells with high effi ciency, high purity in a label-free, non-invasive, easy integration, and low-cost manner. Under the optimal conditions, the separation effi ciency reached 92%, 88%, and 96% for human colon cancer cells (HT-29), red blood cells, and white blood cells, respectively. Conclusions In this study, a novel DEP-based microfl uidic chip was proposed to separate HT-29 tumor cells from blood cells and numerically investigated to verify the performance of the biochip design. Our fi ndings could provide a foundation for further theoretical and practical investigations. The proposed system can separate cancer cells from red blood cells and white blood cells as well as off ers numerous advantages, such as compact size, low voltage, high effi ciency, non-invasiveness, and label-free nature. The tumor cell enrichment platform has the potential for application in cancer detection, analysis, and assessment.
Xuan Hung NGUYEN(Xuan Hung NGUYEN ),Thuy Dương TRAN(Thuy Dương TRAN ),Phan Hoai Diem VU(Phan Hoai Diem VU ),Yen Chi DINH(Yen Chi DINH ),Thi Mai Huong DUONG(Thi Mai Huong DUONG ),Thi Ngoc Hien THAN(Thi 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.9
The goal of the study is to examine and assess how the factors of logistics service quality provided by logistics service providers influence customer loyalty and satisfaction in Vietnam. This study employs samples of the Kansei technique. The article’s data was gathered through an online survey of 388 distinct Vietnamese customers who used logistics services before and during the Covid-19 outbreak. After the data was obtained, it was evaluated using SmartPLS 3.0’s Cronbach’s Alpha test and structural equation model (SEM). Staff service quality, operational service quality, and technical service quality are the three factors that determine the quality of logistics services in the study. Out of the 10 proposed hypotheses, research findings show that five are acceptable. The Covid-19 Pandemic in Vietnam had a significant impact on all dimensions, but it had no effect on how satisfied customers were with the logistics service providers. Nevertheless, loyalty is considerably influenced by only one factor, which is customer satisfaction, and customer trust moderates the relationship between these two factors. As a consequence of that, several managerial implications have been proposed to help logistics service providers improve their services to attract and keep Vietnamese customers using their service in the long term.
NGO, Chi Thanh,NGUYEN, Thi Ngoc Mai,NGUYEN, Duy Dat,LE, Hoang Ba Huyen,LE, Van Cuong,LE, Thi Binh Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
The study aims to investigate factors affecting enterprise's satisfaction and loyalty toward the Social Security's online public services, looking at the case of Thanh Hoa province, Vietnam. This study employs samples with 216 enterprises that use online public system of Thanh Hoa province's Social Security. The research model is closely linked to the SERVQUAL model developed by Parasuraman, Zeithaml and Berry (1988). We propose 23 scales that constitute the quality of service, three scales that constitute Customer Satisfaction and three components that constitute Customer Loyalty. This study use the tool of Exploratory Factor Analysis (EFA), Cronbach's Alpha test, Confirm Factor Analysis (CFA) and Structural Equation Modeling (SEM) in order to address the question of satisfaction and loyalty. The result shows that the factor with the most impact is Reliability, next is Capacity of staffs, Tangibles, Attitude of staffs, and the least impacting factor is Empathy; moreover, the results also show that Satisfaction has a strong impact on Customer Loyalty. The findings of this study suggest that Thanh Hoa province's Social Security should: (i) strengthen the reliability of online service system; (ii) build capacity for staffs; (iii) develop the responsiveness of electronic transactions systems; and (iv) improve the empathy of staffs.
The Moderating Role of CSR Associations on the Link between Brand Awareness and Purchase Intention
HOANG, Xuan Lam,NGUYEN, Thi Kim Chi,LY, Hoang Mai,LUONG, Thu Thuy,NGUYEN, Thi Thanh Quy Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.6
This study uses the moderating model to explore the relationships between Corporate Social Responsibility (CSR) associations, brand awareness and consumer purchase intention. Besides investigating the direct effects of CSR associations on brand awareness and consumer purchase intention, this study also focuses on discovering the moderating role of CSR associations on the relationship between brand awareness and consumer purchase intention among Vietnamese students. Adapting scales from previous research, the authors distribute questionnaires to consumers across the country. Then, the validity and reliability are tested via Cronbach's alpha, Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA). Moreover, by employing a meta-analytical path analysis with a sample of 686 consumers, the authors show that CSR associations play an important role in shaping purchase intention among Vietnamese consumers regarding the consumption of organic milk products. Also, CSR associations have a strong effect on brand awareness. However, our study shows that purchase intention is not directly affected by brand awareness. In other words, brand awareness does not mediate the relationship between CSR associations and purchase intention. Interestingly, authors show that CSR associations moderate the link between brand awareness and consumer purchase intention. Based on the research, some recommendations are made to companies that produce organic milk products.
Dang, Quang Le,Kim, Won Ki,Nguyen, Cuong Mai,Choi, Yong Ho,Choi, Gyung Ja,Jang, Kyoung Soo,Park, Myung Soo,Lim, Chi Hwan,Luu, Ngoc Hoang,Kim, Jin-Cheol American Chemical Society 2011 Journal of agricultural and food chemistry Vol.59 No.20
<P>The methanol extract of <I>Annona squamosa</I> seeds was highly active against two phytoparasitic nematodes, <I>Bursaphelenchus xylophilus</I> and <I>Meloidogyne incognita</I>. It efficiently suppressed plant diseases, caused by <I>Phytophthora infestans</I> and <I>Puccinia recondita</I>. Ten annonaceous acetogenins (AAs) were isolated, and their chemical structures were identified by mass and nuclear magnetic resonance spectral data. Out of 10 substances, eight displayed strong in vitro nematicidal activity against <I>B. xylophilus</I> with LD<SUB>50</SUB> values ranging 0.006 to 0.048 μg/mL. Squamocin-G showed potent nematicidal activity against <I>M. incognita</I>. Squamocin, squamocin-G, and squamostatin-A also displayed potent in vitro and in vivo antifungal activities against <I>P. infestans</I> causing tomato late blight. In addition, squamostatin-A effectively controlled the development of wheat leaf rust caused by <I>P. recondita</I>. Our findings suggested that <I>A. squamosa</I> seeds and its bioactive AAs can be an alternative resource of a promising botanical nematicide and fungicide to control various plant diseases.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2011/jafcau.2011.59.issue-20/jf203017f/production/images/medium/jf-2011-03017f_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf203017f'>ACS Electronic Supporting Info</A></P>
( Christiane Liers ),( Rene Ullrich ),( Harald Kellner ),( Do Huu Chi ),( Dang Thu Quynh ),( Nguyen Dinh Luyen ),( Le Mai Huong ),( Martin Hofrichter ),( Do Huu Nghi ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.10
A bifunctional glycoside hydrolase GH78 from the ascomycete Xylaria polymorpha (XpoGH78) possesses catalytic versatility towards both glycosides and esters, which may be advantageous for the efficient degradation of the plant cell-wall complex that contains both diverse sugar residues and esterified structures. The contribution of XpoGH78 to the conversion of lignocellulosic materials without any chemical pretreatment to release the water-soluble aromatic fragments, carbohydrates, and methanol was studied. The disintegrating effect of enzymatic lignocellulose treatment can be significantly improved by using different kinds of hydrolases and phenoloxidases. The considerable changes in low (3 kDa), medium (30 kDa), and high (> 200 kDa) aromatic fragments were observed after the treatment with XpoGH78 alone or with this potent cocktail. Synergistic conversion of rape straw also resulted in a release of 17.3 mg of total carbohydrates (e.g., arabinose, galactose, glucose, mannose, xylose) per gram of substrate after incubating for 72 h. Moreover, the treatment of rape straw with XpoGH78 led to a marginal methanol release of approximately 17 μg/g and improved to 270 μg/g by cooperation with the above accessory enzymes. In the case of beech wood conversion, the combined catalysis by XpoGH78 and laccase caused an effect comparable with that of fungal strain X. polymorpha in woody cultures concerning the liberation of aromatic lignocellulose fragments.