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RISS 인기검색어
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- 저자 : Naoyuki Ochiai (검색결과 2 건)
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Jang, In-Hwan,Chosa, Naoyuki,Kim, Sung-Hee,Nam, Hyuck-Jin,Lemaitre, Bruno,Ochiai, Masanori,Kambris, Zakaria,Brun, Sylvain,Hashimoto, Carl,Ashida, Masaaki,Brey, Paul T.,Lee, Won-Jae Elsevier 2006 Developmental cell Vol.10 No.1
<P><B>Summary</B></P><P>The Toll receptor was originally identified as an indispensable molecule for <I>Drosophila</I> embryonic development and subsequently as an essential component of innate immunity from insects to humans. Although in <I>Drosophila</I> the Easter protease processes the pro-Spätzle protein to generate the Toll ligand during development, the identification of the protease responsible for pro-Spätzle processing during the immune response has remained elusive for a decade. Here, we report a protease, called Spätzle-processing enzyme (SPE), required for Toll-dependent antimicrobial response. Flies with reduced SPE expression show no noticeable pro-Spätzle processing and become highly susceptible to microbial infection. Furthermore, activated SPE can rescue ventral and lateral development in embryos lacking Easter, showing the functional homology between SPE and Easter. These results imply that a single ligand/receptor-mediated signaling event can be utilized for different biological processes, such as immunity and development, by recruiting similar ligand-processing proteases with distinct activation modes.</P>
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Arata Watanabe,Masataka Sakane,Toru Funayama,Masashi Iwasashi,Akihiro Kanamori,Naoyuki Ochiai 한국생체재료학회 2010 생체재료학회지 Vol.14 No.1
A microstructure of unidirectional porous hydroxyapatite (UDPHAp) has a diameter of 100-300 μm, which pene-trates through the material. In addition, it has a porosity of 75% and initial compression strength of approximately 14 MPa. The objective of the present study was to investigate the feasibility of UDPHAp for the tibial wedge osteot-omy in canines. We performed the operation on the right tibia of the dogs, and a wedge-shaped UDPHAp was implanted in the gap after the osteotomy. At 6 and 12 weeks after the operation, the specimens were solid and bony union could be macroscopically observed. Radiological examination revealed that complete consolidation between the osteotomy site and the UDPHAp was established at 12 weeks. Histological evaluation revealed fibrous tissues between the host bone and the UDPHAp at 6 weeks, although new bone formation was observed at the edges of the material. At 12 weeks, direct bonding and bone ingrowth was observed. This study indicates that UDPHAp has great potential for use as a bone substitute for open-wedge high tibail osteotomy in clinical condition.
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