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The effect of ionizing radiation on robotic trajectory movement and electronic components
Coloma Sofía,Espinosa Peralta Paul,Redondo Violeta,Moroño Alejandro,Vila Rafael,Ferre Manuel 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.11
Robotics applications are greatly needed in hazardous locations, e.g., fusion and fission reactors, where robots must perform delicate and complex tasks under ionizing radiation conditions. The drawback is that some robotic parts, such as active electronics, are susceptible to radiation. It can lead to unexpected failures and early termination of the robotic operation. This paper analyses the ionizing radiation effect from 0.09 to 1.5 Gy/s in robotic components (microcontrollers, servo motors and temperature sensors). The first experiment compares the performance of various microcontroller types and their actuators and sensors, where different mitigation strategies are applied, such as using Radiation-Hardened (Rad-Hard) microcontrollers or shielding. The second and third experiments analyze the performance of a 3-Degrees of Freedom (DoF) robotic arm, evaluating its components ʼ responses and trajectory. This study enhances our understanding and expands our knowledge regarding radiationʼs impact on robotic arms and components, which is useful for defining the best strategies for extending the robotsʼ operational lifespan, especially when performing maintenance or inspection tasks in radiation environments.
Alejandro La Greca,Claudia Solari,Veronica Furmento,Antonella Lombardi,Maria Celeste Biani,Cyntia Aban,Lucia Moro,Marcela García,Alejandra Sonia Guberman,Gustavo Emilio Sevlever,Santiago Gabriel Miriu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Mesenchymal stem/stromal cells (MSCs) obtained from pluripotent stem cells (PSCs) constitute an interesting alternative to classical MSCs in regenerative medicine. Among their many mechanisms of action, MSC extracellular vesicles (EVs) are a potential suitable substitute for MSCs in future cell-free-based therapeutic approaches. Unlike cells, EVs do not elicit acute immune rejection, and they can be produced in large quantities and stored until ready to use. Although the therapeutic potential of MSC EVs has already been proven, a thorough characterization of MSC EVs is lacking. In this work, we used a label-free liquid chromatography tandem mass spectrometry proteomic approach to identify the most abundant proteins in EVs that are secreted from MSCs derived from PSCs (PD-MSCs) and from their parental induced PSCs (iPSCs). Next, we compared both datasets and found that while iPSC EVs enclose proteins that modulate RNA and microRNA stability and protein sorting, PD-MSC EVs are rich in proteins that organize extracellular matrix, regulate locomotion, and influence cell–substrate adhesion. Moreover, compared to their respective cells, iPSCs and iPSC EVs share a greater proportion of proteins, while the PD-MSC proteome appears to be more specific. Correlation and principal component analysis consistently aggregate iPSCs and iPSC EVs but segregate PD-MSC and their EVs. Altogether, these findings suggest that during differentiation, compared with their parental iPSC EVs, PDMSC EVs acquire a more specific set of proteins; arguably, this difference might confer their therapeutic properties.
A New Allelic Variant in the PANK2 Gene in a Patient with Incomplete HARP Syndrome
Myriam Ley Martos,María Jesús Salado Reyes,Rosario Marín Iglesias,Carmen Gutiérrez Moro,Manuel Lubián Gutiérrez,Lorena Estepa Pedregosa 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disease characterized by iron deposition in the basal ganglia, primarily in the globus pallidus and substantia nigra. Common clinical manifestations include dystonia, parkinsonism, spasticity, neuropsychiatric disorders and retinal degeneration. PKAN is included in the spectrum of disorders related to neurodegeneration with brain iron accumulation (NBIA), which includes eleven diseases.
Vicente Pla-Martí,Jose Martín-Arévalo,Rosa Martí-Fernández,David Moro-Valdezate,Stephanie García-Botello,Alejandro Espí-Macías,Miguel Mínguez-Pérez,Maria Dolores Ruiz-Carmona,Jose Vicente Roig-Vila 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.1
Purpose: This study was performed to evaluate the long-term evolution of continence and patient’s quality of life after surgical treatment for obstetric fecal incontinence. Methods: A prospective longitudinal study was conducted including consecutive patients who underwent sphincteroplasty for severe obstetric fecal incontinence. The first phase analyzed changes in continence and impact on quality of life. The second phase studied the long-term evolution reevaluating the same group of patients 6 years later. Degree of fecal incontinence was calculated using the Cleveland Clinic Score (CCS). Quality of life assessment was carried out with the Fecal Incontinence Quality of Life scale. Results: Thirty-five patients with median age of 55 years (range, 28 to 73 years) completed the study. Phase 1 results: after a postoperative follow-up of 30 months (4 to 132 months), CCS had improved significantly from a preoperative of 15.7±3.1 to 6.1±5.0 (P<0.001). Phase 2 results: median follow-up in phase 2 was 110 months (76 to 204 months). The CCS lowered to 8.4±4.9 (P=0.04). There were no significant differences between phases 1 and 2 in terms of quality of life; lifestyle (3.47± 0.75 vs. 3.16±1.04), coping/behavior (3.13±0.83 vs. 2.80±1.09), depression/self-perception (3.65±0.80 vs. 3.32± 0.98), and embarrassment (3.32±0.90 vs. 3.12±1.00). Conclusion: Sphincteroplasty offers good short-medium term outcomes in continence and quality of life for obstetric fecal incontinence treatment. Functional clinical results deteriorate over time but did not impact on patients’ quality of life.
Cho, Y.,Cole, R.,Ikaga, T.,Larsson, N.,Moro, A.,Rovers, R.,Shin, S. Sustainable Building Research Center 2010 International journal of sustainable building tech Vol.1 No.1
The purpose of the discussion is to enhance the understanding of importance of sustainable development in the industry and to expand the international relation on the technology of sustainable architecture. The theme of SB10 SEOUL conference, "Sustainable Building Assessment Technology and Strategies for Higher Education" is selected to expand the knowledge of the current condition and the direction of future in sustainable building assessment technology.