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( Minseok Albert Kim ),( Jeong-hoon Lee ),( Sungwon Chung ),( Sun Woong Kim ),( Jun Sik Yoon ),( Young Chang ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The seroclearance of hepatitis B virus (HBV) surface antigen (HBsAg) is currently considered as a functional cure of chronic hepatitis B. However, there is still a lack of evidence whether the HBsAg-seroclearance is a reliable and durable indicator of HBV eradication. In this study, we aimed to evaluate the reliability and durability of NA-induced HBsAg-seroclearance. Methods: Among 1,100 patients with chronic hepatitis B, 33 patients who achieved HBsAg-seroclearance with NA treatment between January 2010 and December 2017 at a single referral center were analyzed retrospectively. HBsAg was examined using ELISA kit (ARCHITECT HBsAg Qualitative II; Abbott, Wiesbaden, Germany) and < 1.17 S/Co (~0.02 IU/mL) was defined as a negativity. Results: The median age at NA-induced HBsAg-seroclearance was 59.8 (range, 22.4-74.6) years and median NA treatment duration before seroclearance was 76.1 (range, 11.3-193.5) months. At the time of HBsAg-seroclearance, all patients had undetectable serum HBV DNA (< 20 IU/mL). Among them, 22 patients (66.7%) stopped NAs after HBsAg-seroclearance (the NA-off group) and the remaining 11 patients (33.3%) maintained NAs for median 23.5 (range, 5.0-49.8) months (the NA-maintenance group) after HBsAg-seroclearance. During follow-up period (median, 35.0 months; range, 4.7-89.9), two patients (one in the NA-off group and one in the NA-maintenance group) experienced HBsAg-seroreversion although their serum HBV DNA were not detectable. Of the two patents, a patient who are in the NA-maintenance group developed HBsAg-seroreversion at 19 months after HBsAg-seroclearance and again experienced HBsAg-re-seroclearance 17 months later. Interestingly, both patients experiencing HBsAg-seroreversion had hepatocellular carcinoma. Conclusions: A single time negative-conversion of HBsAg might not be a reliable and durable indicator of HBV eradication since there were a few cases of detectable HBV DNA and HBsAg-seroreversion. Thus, repeated evaluation of both HBsAg and HBV DNA might be necessary to confirm the functional cure of chronic hepatitis B undergoing antiviral treatment.
Kim, Minseok,Kim, Minkyu,Kim, Doogyum,Lee, Jongwoo The Korean Society for Railway 2012 International Journal of Railway Vol.5 No.2
Railroad signaling systems are to control intervals and routes of trains. There are ATS, ATP, ATO and ATC system. Trains are operated in the section which is met on the signaling system because various signaling systems are used in Korea. Hence, trains are not operated in the section which is used in the other signaling system. To solve this problem, recently combined on-board system has been developed. The combined on-board system designed by doubling the ATS, ATP and ATC system to ensure the safety of system. The inductance of antenna is change and in return the resonance frequency of antenna is varied by the electromagnetic induction. Therefore, the information signal is not received exactly in the combined on-board system and in return accidents between trains occur. In this paper, electric model of the combined on-board system for considering the ATS and ATP antenna is presented. Moreover, the mutual inductance including the distance between the ATS and ATP antenna is calculated. As a result of the frequency response of the antennas, the mutual inductance met on operation range of resonance frequency is defined.
Minseok Kim,Minkyu Kim,Doogyum Kim,Jongwoo Lee 한국철도학회 2012 International Journal of Railway Vol.5 No.2
Railroad signaling systems are to control intervals and routes of trains. There are ATS, ATP, ATO and ATC system. Trains are operated in the section which is met on the signaling system because various signaling systems are used in Korea. Hence, trains are not operated in the section which is used in the other signaling system. To solve this problem, recently combined on-board system has been developed. The combined on-board system designed by doubling the ATS, ATP and ATC system to ensure the safety of system. The inductance of antenna is change and in return the resonance frequency of antenna is varied by the electromagnetic induction. Therefore, the information signal is not received exactly in the combined on-board system and in return accidents between trains occur. In this paper, electric model of the combined on-board system for considering the ATS and ATP antenna is presented. Moreover, the mutual inductance including the distance between the ATS and ATP antenna is calculated. As a result of the frequency response of the antennas, the mutual inductance met on operation range of resonance frequency is defined.
A STUDY ON MEASUREMENT FOR LARGE SIZE OBJECTS WITH A NON-CONTACT TYPE CMM
Minseok Kim,Dongeun Lee,Sookhan Kim,Jeongnak Lee,Junchul Kim,Eungki Lee 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
Recently, efficient manufacturing of high precision is an important issue in modern industry as more variety of industrial products is being designed with compound surfaces. Rapid CAD data generation can be possible based on a non-contact type CMM of object through the use of reverse engineering. However, some registration to match the data measured from various directions into a common coordinate system is required. Also, the error can happen if it uses the conventional method to large product of thin thickness. So it is necessary to develop a new method, which was designed for the registration of large and thin products. Additionally, an algorithm to pick up coordinates for the newly designed method was proposed.
Cracking-assisted fabrication of nanoscale patterns for micro/nanotechnological applications
Kim, Minseok,Kim, Dong-Joo,Ha, Dogyeong,Kim, Taesung The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.18
<P>Cracks are frequently observed in daily life, but they are rarely welcome and are considered as a material failure mode. Interestingly, cracks cause critical problems in various micro/nanofabrication processes such as colloidal assembly, thin film deposition, and even standard photolithography because they are hard to avoid or control. However, increasing attention has been given recently to control and use cracks as a facile, low-cost strategy for producing highly ordered nanopatterns. Specifically, cracking is the breakage of molecular bonds and occurs simultaneously over a large area, enabling fabrication of nanoscale patterns at both high resolution and high throughput, which are difficult to obtain simultaneously using conventional nanofabrication techniques. In this review, we discuss various cracking-assisted nanofabrication techniques, referred to as crack lithography, and summarize the fabrication principles, procedures, and characteristics of the crack patterns such as their position, direction, and dimensions. First, we categorize crack lithography techniques into three technical development levels according to the directional freedom of the crack patterns: randomly oriented, unidirectional, or multidirectional. Then, we describe a wide range of novel practical devices fabricated by crack lithography, including bioassay platforms, nanofluidic devices, nanowire sensors, and even biomimetic mechanosensors.</P>
A case of cellulitis-like foreign body reaction after hyaluronic acid dermal filler injection
( Minseok Kim ),( Wonjoo Kwon ),( Eunbyul Cho ),( Eunjoo Park ),( Kwangho Kim ),( Kwangjoong Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
A 58-year-old female presented with 3 weeks history of painful skin lesion on the right cheek. The lesion was erythematous and edematous patch on the right cheek. Impression at first visit was cellulitis based on the clinical manifestation and mild elevated ESR and CRP levels in laboratory test. But her symptom and skin lesion were not improved with antibiotics so that biopsy was performed on her right cheek. Histologic examination showed diffuse inflammatory cells infiltration dominantly lymphocytes and some histiocytes. Multiple, clear vacuoles were remarkably observed forming “Swiss cheese” appearance, which is the histologic feature of foreign body reaction. Based on these findings, additional information of previous intradermal filler injection on both cheeks was obtained from the patient after biopsy. Since the treatment with oral antibiotics, systemic steroid, intralesional steroid and hyaluronidase injection, her cutaneous lesion and symptom have been improved. Previously reported foreign body reactions induced by hyaluronic acid dermal filler were typically manifested as nodular lesions at injection site, but cellulitis-like cutaneous manifestation as seen in this case has not been reported. Therefore, we report this interesting case of cellulitis-like foreign body reaction after hyaluronic acid dermal filler.