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Silver (I)- Schiff-base complex intercalated layered double hydroxide with antimicrobial activity
Barnabas, Mary Jenisha,Parambadath, Surendran,Nagappan, Saravanan,Chung, Ildoo,Ha, Chang-Sik Techno-Press 2021 Advances in nano research Vol.10 No.4
In this work, silver nitrate complexes of sulfanilamide-5-methyl-2-thiophene carboxaldehyde (SMTCA) ligand intercalated Zn/Al-layered double hydroxide [Ag-SMTCA-LDH] were synthesized for the potential application as an antimicrobial system. The SMTCA ligand was synthesized by reacting sulfanilamide and 5-methyl-2-thiophene carboxaldehyde in methanol and further complexation with silver nitrate metal ions [Ag-SMTCA]. The structural analyses of synthesized compounds confirmed an intercalation of Ag-SMTCA into Zn/Al-NO<sub>3</sub>-LDH by flake/restacking method. SMTCA, Ag-SMTCA and Ag-SMTCA-LDH were characterized by <sup>1</sup>H nuclear magnetic resonance (<sup>1</sup>H NMR) spectroscopy, Fourier-transform infrared (FTIR), ultraviolet-visible (UV-Vis) spectrophotometer, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). It was found that Ag-SMTCA-LDH exhibited good antimicrobial activity against both gram-positive (Bacillus subtilis, [B. subtilis], Staphylococcus aures, [S. aureus]) and gram-negative (Escherichia coli, [E. coli], Pseudomonas aeruginosa [P. aeroginosa]) bacteria as well as excellent antioxidant activity.
Mary Jenisha Barnabas,Surendran Parambadath,하창식 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-
layered double hydroxide-mesoporous silica core–shell nanostructure (LDH@mSiO2) with perpendicularly- oriented mesochannels was synthesised using a surfactant-directing method and modified with amine functionality for drug delivery applications. Mg/Al-layered double hydroxide (Mg/Al-LDH) materials with a disc-like morphology were synthesised and then coated with mesoporous silica (Mg/Al- LDH@mSiO2) via the functionalisation of (3-aminopropyl)triethoxysilane using a post-synthesis route (NH2-Mg/Al-LDH@mSiO2). The materials were characterised using a range of techniques. The Mg/Al- LDH@mSiO2 and NH2-Mg/Al-LDH@mSiO2 materials possessed a spherical morphology and good porosity. Ibuprofen (IBU) and ciprofloxacin (CIPRO) were loaded into the pore channels of the NH2-Mg/ Al-LDH@mSiO2 and the release properties were examined at pH 4.0 and 7.4. The delayed release property exhibited by NH2-Mg/Al-LDH@mSiO2 was attributed to the strong interactions of the drug molecules with the surface amino functionality and the charged LDH surface. The release profile from NH2-Mg/Al- LDH@mSiO2 was also compared with that of the Mg/Al-LDH@mSiO2 system under identical conditions. The porosity and functionalisation of the mesoporous silica shell and the surface charge density of the layered structure of Mg/Al-LDH are the major reasons for the controlled release of the cargo molecules. Moreover, the favourable delay in drug release from both materials at pH 4 was attributed to the higher level of ionisation and dissolution than at pH 7.4.