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Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N American Physical Society 2017 Physical Review D Vol.96 No.3
<P>A measurement of the top quark mass (M-t) in the dileptonic t (t) over bar decay channel is performed using data from proton-proton collisions at a center-of-mass energy of 8 TeV. The data was recorded by the CMS experiment at the LHC and corresponds to an integrated luminosity of 19.7 +/- 0.5 fb(-1). Events are selected with two oppositely charged leptons (l = e, mu) and two jets identified as originating from b quarks. The analysis is based on three kinematic observables whose distributions are sensitive to the value of Mt. An invariant mass observable, M-bl, and a 'stransverse mass' observable, M-T2, are employed in a simultaneous fit to determine the value of M-t and an overall jet energy scale factor (JSF). A complementary approach is used to construct an invariant mass observable, M-blv, that is combined with M-T2 to measure M-t. The shapes of the observables, along with their evolutions in M-t and JSF, are modeled by a nonparametric Gaussian process regression technique. The sensitivity of the observables to the value of M-t is investigated using a Fisher information density method. The top quark mass is measured to be 172.22 +/- 0.18(stat)(-0.93)(+0.89) (syst) GeV.</P>
A mathematical model for the two-learners problem
Mü,ller, Jan Saputra,Vidaurre, Carmen,Schreuder, Martijn,Meinecke, Frank C,von Bü,nau, Paul,Mü,ller, Klaus-Robert IOP 2017 Journal of neural engineering Vol.14 No.3
<P> <I>Objective</I>. We present the first generic theoretical formulation of the co-adaptive learning problem and give a simple example of two interacting linear learning systems, a human and a machine. <I>Approach</I>. After the description of the training protocol of the two learning systems, we define a simple linear model where the two learning agents are coupled by a joint loss function. The simplicity of the model allows us to find learning rules for both human and machine that permit computing theoretical simulations. <I>Main results</I>. As seen in simulations, an astonishingly rich structure is found for this eco-system of learners. While the co-adaptive learners are shown to easily stall or get out of sync for some parameter settings, we can find a broad sweet spot of parameters where the learning system can converge quickly. It is defined by mid-range learning rates on the side of the learning machine, quite independent of the human in the loop. Despite its simplistic assumptions the theoretical study could be confirmed by a real-world experimental study where human and machine co-adapt to perform cursor control under distortion. Also in this practical setting the mid-range learning rates yield the best performance and behavioral ratings. <I>Significance</I>. The results presented in this mathematical study allow the computation of simple theoretical simulations and performance of real experimental paradigms. Additionally, they are nicely in line with previous results in the BCI literature.</P>
Mü,ller, Martin C.,Cortes, Jorge E.,Kim, Dong-Wook,Druker, Brian J.,Erben, Philipp,Pasquini, Ricardo,Branford, Susan,Hughes, Timothy P.,Radich, Jerald P.,Ploughman, Lynn,Mukhopadhyay, Jaydip,Hochh American Society of Hematology 2009 Blood Vol.114 No.24
<B>Abstract</B><P>Dasatinib is a BCR-ABL inhibitor with 325-fold higher potency than imatinib against unmutated BCR-ABL in vitro. Imatinib failure is commonly caused by BCR-ABL mutations. Here, dasatinib efficacy was analyzed in patients recruited to phase 2/3 trials with chronic-phase chronic myeloid leukemia with or without BCR-ABL mutations after prior imatinib. Among 1043 patients, 39% had a preexisting BCR-ABL mutation, including 48% of 805 patients with imatinib resistance or suboptimal response. Sixty-threedifferent BCR-ABL mutations affecting 49 amino acids were detected at baseline, with G250, M351, M244, and F359 most frequently affected. After 2 years of follow-up, dasatinib treatment of imatinib-resistant patients with or without a mutation resulted in notable response rates (complete cytogenetic response: 43% vs 47%) and durable progression-free survival (70% vs 80%). High response rates were achieved with different mutations except T315I, including highly imatinib-resistant mutations in the P-loop region. Impaired responses were observed with some mutations with a dasatinib median inhibitory concentration (IC50) greater than 3nM; among patients with mutations with lower or unknown IC50, efficacy was comparable with those with no mutation. Overall, dasatinib has durable efficacy in patients with or without BCR-ABL mutations. All trials were registered at http://www.clinicaltrials.gov as NCT00123474, NCT00101660, and NCT00103844.</P>
Measurement of the inelastic proton-proton cross section at s = 13 $$ \sqrt{s}=13 $$ TeV
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Escalante Del Valle, A.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Gh Springer-Verlag 2018 Journal of high energy physics Vol.2018 No.7
<P>A measurement of the inelastic proton-proton cross section with the CMS detector at a center-of-mass energy of root s = 13 TeV is presented. The analysis is based on events with energy deposits in the forward calorimeters, which cover pseudorapidities of -6.6 < eta < -3.0 and +3.0 < eta < +5.2. An inelastic cross section of 68.6 +/- 0.5(syst) +/- 1.6(lumi) mb is obtained for events with M-x > 4.1 GeV and/or M-Y > 13 GeV, where M-x and M-Y are the masses of the diffractive dissociation systems at negative and positive pseudorapidities, respectively. The results are compared with those from other experiments as well as to predictions from high-energy hadron-hadron interaction models.</P>
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Grossmann, J. Springer 2017 European Physical Journal C Vol.77 No.10
<P>A search for new phenomena is performed using events with jets and significant transverse momentum imbalance, as inferred through the M-T2 variable. The results are based on a sample of proton-proton collisions collected in 2016 at a center-of-mass energy of 13 TeV with the CMS detector and corresponding to an integrated luminosity of 35.9 fb(-1). No excess event yield is observed above the predicted standard model background, and the results are interpreted as exclusion limits at 95% confidence level on the masses of predicted particles in a variety of simplified models of R-parity conserving supersymmetry. Depending on the details of the model, 95% confidence level lower limits on the gluino (light-flavor squark) masses are placed up to 2025 (1550) GeV. Mass limits as high as 1070 (1175) GeV are set on the masses of top (bottom) squarks. Information is provided to enable re-interpretation of these results, including model-independent limits on the number of non-standard model events for a set of simplified, inclusive search regions.</P>
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Grossmann, J. Institute of Physics Pub 2017 The journal of high energy physics Vol.2017 No.8
<P>Searches are presented for heavy gauge bosons decaying into a top and a bottom quark in data collected by the CMS experiment at root s = 13TeV that correspond to an integrated luminosity of 2.2 and 2.6 fb 1 in the leptonic and hadronic analyses, respectively. Two final states are analyzed, one containing a single electron, or muon, and missing transverse momentum, and the other containing multiple jets and no electrons or muons. No evidence is found for a right-handed W' boson (W'(R)) and the combined analyses exclude at 95% confidence level W'(R) with masses below 2.4TeV if M-W'R >> M-vR (mass of the right-handed neutrino), and below 2.6TeV if M-W'R < M-vR. The results provide the most stringent limits for right-handed W' bosons in the top and bottom quark decay channel.</P>
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N Springer 2017 European Physical Journal C Vol.77 No.11
<P>A measurement is presented of the triple-differential dijet cross section at a centre-of-mass energy of 8 TeV using 19.7 fb(-1) of data collected with the CMS detector in proton-proton collisions at the LHC. The cross section is measured as a function of the average transverse momentum, half the rapidity separation, and the boost of the two leading jets in the event. The cross section is corrected for detector effects and compared to calculations in perturbative quantum chromodynamics at next-to-leading order accuracy, complemented with electroweak and nonperturbative corrections. New constraints on parton distribution functions are obtained and the inferred value of the strong coupling constant is alpha(S)(M-Z) = 0.1199 +/- 0.0015 (exp)(-0.0020)(+0.0031) (theo), where M-Z is the mass of the Z boson.</P>
Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,Kiesenhofer, Institute of Physics Pub 2015 The journal of high energy physics Vol.2015 No.5
<P>Searches for supersymmetry (SUSY) are performed using a sample of hadronic events produced in 8 TeV pp collisions at the CERN LHC. The searches are based on the M-T2 variable, which is a measure of the transverse momentum imbalance in an event. The data were collected with the CMS detector and correspond to an integrated luminosity of 19.5 fb(-1). Two related searches are performed. The first is an inclusive search based on signal regions defined by the value of the M-T2 variable, the hadronic energy in the event, the jet multiplicity, and the number of jets identified as originating from bottom quarks. The second is a search for a mass peak corresponding to a Higgs boson decaying to a bottom quark-antiquark pair, where the Higgs boson is produced as a decay product of a SUSY particle. For both searches, the principal backgrounds are evaluated with data control samples. No significant excess over the expected number of background events is observed, and exclusion limits on various SUSY models are derived.</P>