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      • KCI등재

        Anisotropic In-plane Resistivity and Magnetoresistance of the Detwinned BaFe2As2

        Lin Jiao,Zong Fa Weng,Xue Yan Tang,Lu Kai Guo,Tian Shang,Lin Yang,Hui Qiu Yuan,Yu Ying Wu,Zheng Cai Xia 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3

        We have measured the electrical resistivity and the magnetoresistance of detwinned BaFe2As2single crystals in fields up to 16 Tesla. The temperature dependence of the resistivity shows acounterintuitive anisotropic behavior in the ab-plane, likely arising from the effect of the nematicsusceptibility. Little magnetoresistance is observed at temperatures above the structural/magnetictransition, below which a huge in-plane magnetoresistance with an anisotropy is detected.

      • Expression of the Pokemon Proto-oncogene in Nasopharyngeal Carcinoma Cell Lines and Tissues

        Jiao, Wei,Liu, Fei,Tang, Feng-Zhu,Lan, Jiao,Xiao, Rui-Ping,Chen, Xing-Zhou,Ye, Hui-Lan,Cai, Yong-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        To study the differentiated expression of the proto-oncogene Pokemon in nasopharyngeal carcinoma (NPC) cell lines and tissues, mRNA and protein expression levels of CNE1, CNE2, CNE3 and C666-1 were detected separately by reverse transcription polymerase chain reaction (RT-PCR), real-time PCR and Western-blotting. The immortalized nasopharyngeal epithelial cell line NP69 was used as a control. The Pokemon protein expression level in biopsy specimens from chronic rhinitis patients and undifferentiated non keratinizing NPC patients was determined by Western-blotting and arranged from high to low: C666-1>CNE1>CNE2> CNE3>NP69. The Pokemon mRNA expression level was also arranged from high to low: CNE1>CNE2>NP69>C666-1>CNE3. Pokemon expression of NP69 and C666-1 obviously varied from mRNA to protein. The Pokemon protein level of NPC biopsy specimens was obviously higher than in chronic rhinitis. The data suggest that high Pokemon protein expression is closely associated with undifferentiated non-keratinizing NPC and may provide useful information for NPC molecular target therapy.

      • Fermi surface reconstruction and multiple quantum phase transitions in the antiferromagnet CeRhIn<sub>5</sub>

        Jiao, Lin,Chen, Ye,Kohama, Yoshimitsu,Graf, David,Bauer, E. D.,Singleton, John,Zhu, Jian-Xin,Weng, Zongfa,Pang, Guiming,Shang, Tian,Zhang, Jinglei,Lee, Han-Oh,Park, Tuson,Jaime, Marcelo,Thompson, J. D National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.3

        <P><B>Significance</B></P><P>Conventional, thermally driven continuous phase transitions are described by universal critical behavior that is independent of microscopic details of a specific material. An analogous description is lacking for phase transitions that are driven at absolute zero temperature by a nonthermal control parameter. Classification of quantum-driven phase transitions is a fundamental but open problem that arises in diverse contexts and multiple classes of materials. Here we report the first observation, to our knowledge, of a sharp Fermi surface reconstruction while applying a strong magnetic field to suppress an antiferromagnetic transition to zero temperature. These experiments demonstrate that direct measurements of the Fermi surface can distinguish theoretically proposed models of quantum criticality and point to a universal description of quantum phase transitions.</P><P>Conventional, thermally driven continuous phase transitions are described by universal critical behavior that is independent of the specific microscopic details of a material. However, many current studies focus on materials that exhibit quantum-driven continuous phase transitions (quantum critical points, or QCPs) at absolute zero temperature. The classification of such QCPs and the question of whether they show universal behavior remain open issues. Here we report measurements of heat capacity and de Haas–van Alphen (dHvA) oscillations at low temperatures across a field-induced antiferromagnetic QCP (<I>B</I><SUB>c0</SUB> ≈ 50 T) in the heavy-fermion metal CeRhIn<SUB>5</SUB>. A sharp, magnetic-field-induced change in Fermi surface is detected both in the dHvA effect and Hall resistivity at [Formula] ≈ 30 T, well inside the antiferromagnetic phase. Comparisons with band-structure calculations and properties of isostructural CeCoIn<SUB>5</SUB> suggest that the Fermi-surface change at [Formula] is associated with a localized-to-itinerant transition of the Ce-4<I>f</I> electrons in CeRhIn<SUB>5</SUB>. Taken in conjunction with pressure experiments, our results demonstrate that at least two distinct classes of QCP are observable in CeRhIn<SUB>5</SUB>, a significant step toward the derivation of a universal phase diagram for QCPs.</P>

      • KCI등재

        Enhancement of Haloacetate Dehalogenase Production by Strain Mutation and Condition Optimization

        Chun-jiao Lin,Li-rong Yang,Gang Xu,Jian-ping Wu 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.5

        Enhancement of the activity of an inducible chloroacetate dehalogenase was carried out by efficient and safe mutation with UV and microwave irradiation along with optimization of culture conditions. First, a stable mutant of Pseudomonas sp. CGMCC 3267-MW6 with chloroacetate dehalogenase activity of 2.77 U/mL (3-fold higher activity than the wild strain) was produced by mutation. The maximum activity of this inducible enzyme was measured as 29.41 U/mL when Pseudomonas sp. CGMCC 3267-MW6 was cultured with 4 g/L 3-hydroxybutyrate for 12 h followed by 40 mM 3-chlorobutyrate for an additional 20 h. Production of the enzyme was found to be associated with growth of the bacterium. According to these results, we determined that the optimum inducer of chloroacetate dehalogenase activity would be a hard degradable substrate. The optimum auxiliary carbon source would be the primary metabolite of the substrate or the precursor of the metabolite. The optimum time of inducer supplementation would be during the middle stage of exponential phase. The optimum concentration of substrate would be sufficient but would not induce inhibition. Finally, the optimum collection time would be at the later stage of exponential phase. This work provides further knowledge of chloroacetate dehalogenase and the optimization of inducible enzyme production.

      • SCIESCOPUSKCI등재

        GPR12 Selections of the Metabolites from an Endophytic Streptomyces sp. Asociated with Cistanches deserticola

        Lin, Zhen-Jian,Lu, Xiao-Ming,Zhu, Tian-Jiao,Fang, Yu-Chun,Gu, Qian-Qun,Zhu, Weiming 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

        An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.

      • SCISCIESCOPUS

        Sex determination from the mandibular ramus flexure of Koreans by discrimination function analysis using three-dimensional mandible models

        Lin, C.,Jiao, B.,Liu, S.,Guan, F.,Chung, N.E.,Han, S.H.,Lee, U.Y. Elsevier Sequoia 2014 Forensic science international Vol.236 No.-

        It has been known that mandible ramus flexure is an important morphologic trait for sex determination. However, it will be unavailable when mandible is incomplete or fragmented. Therefore, the anthropometric analysis on incomplete or fragmented mandible becomes more important. The aim of this study is to investigate the sex-discriminant potential of mandible ramus flexure on the Korean three-dimensional (3D) mandible models with anthropometric analysis. The sample consists of 240 three dimensional mandibular models obtained from Korean population (M:F; 120:120, mean age 46.2y), collected by The Catholic Institute for Applied Anatomy, The Catholic University of Korea. Anthropometric information about 11 metric was taken with Mimics, anthropometry libraries toolkit. These parameters were subjected to different discriminant function analyses using SPSS 17.0. Univariate analyses showed that the resubstitution accuracies for sex determination range from 50.4 to 77.1%. Mandibular flexure upper border (MFUB), maximum ramus vertical height (MRVH), and upper ramus vertical height (URVH) expressed the greatest dimorphism, 72.1 to 77.1%. Bivariate analyses indicated that the combination of MFUB and MRVH hold even higher resubstitution accuracy of 81.7%. Furthermore, the direct and stepwise discriminant analyses with the variables on the upper ramus above flexure could predict sex in 83.3 and 85.0%, respectively. When all variables of mandibular ramus flexure were input in stepwise discriminant analysis, the resubstitution accuracy arrived as high as 88.8%. Therefore, we concluded that the upper ramus above flexure hold the larger potentials than the mandibular ramus flexure itself to predict sexes, and that the equations in bivariate and multivariate analysis from our study will be helpful for sex determination on Korean population in forensic science and law.

      • Increases in solar conversion efficiencies of the ZrO <sub>2 </sub> nanofiber-doped TiO <sub>2 </sub> photoelectrode for dye-sensitized solar cells

        Wang, Jiao,Jin, En Mei,Park, Ju-Young,Wang, Wan Lin,Zhao, Xing Guan,Gu, Hal-Bon Springer 2012 NANOSCALE RESEARCH LETTERS Vol.7 No.1

        <P>In this paper, in order to improve the efficiency of dye-sensitized solar cells, we introduced zirconia [ZrO<SUB>2</SUB>] nanofibers into a mesoporous titania [TiO<SUB>2</SUB>] photoelectrode. The photoelectrode consists of a few weight percent of ZrO<SUB>2 </SUB>nanofibers and a mesoporous TiO<SUB>2 </SUB>powder. The mixed ZrO<SUB>2 </SUB>nanofibers and the mesoporous TiO<SUB>2 </SUB>powder possessed a larger surface area than the corresponding mesoporous TiO<SUB>2 </SUB>powder. The optimum ratio of the ZrO<SUB>2 </SUB>nanofiber was 5 wt.%. The 5 wt.% ZrO<SUB>2</SUB>-mixed device could get a short-circuit photocurrent density of 15.9 mA/cm<SUP>2</SUP>, an open-circuit photovoltage of 0.69 V, a fill factor of 0.60, and a light-to-electricity conversion efficiency of 6.5% under irradiation of AM 1.5 (100 mW/cm<SUP>2</SUP>).</P>

      • KCI등재

        Radix ranunculus temate saponins induces apoptosis via the death receptor and mitochondrial pathways in SGC-7901 cells

        Mao-lin Li,Han-min Gu,Hong-ya Hang,Yao-li Jiang,Jiao Jiang,Qian-na Gu,Wen-yan Wu,M.-L. Li 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4

        Radix ranunculus temate saponins (RRTS), one of the main constituents extracted from the popular traditional Chinese medicine Radix Ranunculi ternati, has been reported to have various biological activities including anti-cancer effect. The aim of this study is to investigate the effect of RRTS on the cell proliferation and apoptosis in human gastric adenocarcinoma SGC-7901 cells. The data showed that exposure to RRTS for 24 h produced cytotoxic effects on SGC- 7901 cells in a dose-dependent manner (with an IC50 value of 21.22±2.76 μg/mL), which was accompanied by apoptosis induction (from 2.18±0.89% (control) to 63.72±13.16% (100 μg/mL)). Both the extrinsic or death receptor pathway and the intrinsic or mitochondrial pathway were involved in RRTS-induced apoptosis in SGC-7901 cells. Furthermore, apoptotic signaling induced by RRTS was amplified by cross-link between the two pathways via the signal-integrating protein Bid. In conclusion, our findings contribute to better understanding the molecular mechanism of RRTS’ effect on gastric cancer cells and form the basis of the therapeutic development of RRTS in treating gastric cancer in the future.

      • SCISCIESCOPUS
      • A Simplified Synchronous Pulse-Width Modulation Method for Three-level Inverter of High-speed Train

        Fei Lin,Qiaona Lian,Jialiang Yuan,Zhongping Yang,Zhiqiang Zhang,Yue Xu,Jinghai Jiao 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.12

        The synchronous Pulse-Width Modulation (PWM) is quite complex for three-level neutral point-clamped (NPC) inverter. A simple central 60° synchronous modulation method is presented in this paper for three-level NPC inverter used in the multi-mode PWM strategy. For the fundamental voltage command, the switching angle could be real-time calculated based on this modulation method with different carrier frequency ratios. The switching strategy between these modes is discussed for multi-mode PWM. According to this method, a simulation model of the drive system with three-level inverter and induction motor is built. The simulation results at asynchronous modulation, central 60° synchronous modulation and square wave area, show that the output voltage values can meet the requirements with a good symmetry even in the case of low carrier frequency ratio. The smooth switching among different modes is also accomplished with low impulse current.

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