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MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease
( Kyo-sang Yoo ),( Ho Soon Choi ),( Dae Won Jun ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Kyeong Geun Lee ),( Seung Sam Paik ),( Yong Seok Kim ),( Jin Lee ) 대한간학회 2016 Gut and Liver Vol.10 No.5
Background/Aims: Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several mucin genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression in cholesterolassociated gallbladder disease and evaluated the relationship between mucin and bacterial infection. Methods: The present study involved 20 patients with cholesterol stones with cholecystitis, five with cholesterol stones with cholesterolosis, six with cholesterol polyps, two with gallbladder cancer, and six controls. Canine GBECs treated with lipopolysaccharide were also studied. MUC3, MUC5AC, MUC5B, and MUC6 antibodies were used for dot/slot immunoblotting and immunohistochemical studies of the gallbladder epithelial tissues, canine GBECs, and bile. Reverse-transcription polymerase chain reaction was performed to evaluate MUC3 and MUC5B expression. Results: MUC3, MUC5AC, MUC5B, and MUC6 were expressed in the normal gallbladder epithelium, and of those, MUC3 and MUC5B exhibited the highest expression levels. Greatly increased levels of MUC3 and MUC5B expression were observed in the cholesterol stone group, and slightly increased levels were observed in the cholesterol polyp group; MUC3 and MUC5B mRNA was also upregulated in those groups. Canine GBECs treated with lipopolysaccharide also showed upregulation of MUC3 and MUC5B. Conclusions: The mucin genes with the highest expression levels in gallbladder tissue in cholesterol-associated diseases were MUC3 and MUC5B. Cholesterol stones and gallbladder infections were associated with increased MUC3 and MUC5B expression. (Gut Liver 2016;10:851-858)
Amygdalin Contents in Peaches at Different Fruit Development Stages
Lee, Suk-Hee,Oh, Angela,Shin, Seo-Hee,Kim, Ha-Na,Kang, Woo-Won,Chung, Shin-Kyo The Korean Society of Food Science and Nutrition 2017 Preventive Nutrition and Food Science Vol.22 No.3
Amygdalin contents of the seeds, endocarps, and mesocarps from three peach cultivars (i.e., Stone Peach, Hikawa Hakuho, and Bakhyang) were measured at three stages of fruit development (stone-hardening, fruit enlargement, and ripening). The peach samples were dried and defatted with a Soxhlet apparatus, reflux extracted with methanol, and analyzed using reverse phase high-performance liquid chromatography. During all fruit development stages, the amygdalin contents in the seeds were higher than those in the endocarps and mesocarps. The amygdalin contents of the Stone Peach were comparatively higher than the Hikawa Hakuho and Bakhyang (P<0.05). Further, the amygdalin contents during ripening were very low or not detected. Overall, the amygdalin contents of the three peach cultivar samples (seed, endocarp, and mesocarp) increased until the fruit enlargement stage and either remained constant or decreased during ripening.
Meteorological Determinants of Forest Fire Occurrence in the Fall, South Korea
Won, Myoung-Soo,Miah, Danesh,Koo, Kyo-Sang,Lee, Myung-Bo,Shin, Man-Yong Korean Society of Forest Science 2010 한국산림과학회지 Vol.99 No.2
Forest fires have potentials to change the structure and function of forest ecosystems and significantly influence on atmosphere and biogeochemical cycles. Forest fire also affects the quality of public benefits such as carbon sequestration, soil fertility, grazing value, biodiversity, or tourism. The prediction of fire occurrence and its spread is critical to the forest managers for allocating resources and developing the forest fire danger rating system. Most of fires were human-caused fires in Korea, but meteorological factors are also big contributors to fire behaviors and its spread. Thus, meteorological factors as well as social factors were considered in the fire danger rating systems. A total of 298 forest fires occurred during the fall season from 2002 to 2006 in South Korea were considered for developing a logistic model of forest fire occurrence. The results of statistical analysis show that only effective humidity and temperature significantly affected the logistic models (p<0.05). The results of ROC curve analysis showed that the probability of randomly selected fires ranges from 0.739 to 0.876, which represent a relatively high accuracy of the developed model. These findings would be necessary for the policy makers in South Korea for the prevention of forest fires.
Detection of Minimal Lesion and Identification of Clonality in Malignant Lymphoma
Lee, Kyo Young,Kim, Won Il,Kim, Yong Goo,Kang, Chang Suk,Kim, Young Shin,Han, Kyungja,Shim, Sang In THE CATHOLIC UNIVERSITY OF KOREA 1997 Bulletin of The Catholic Research Institutes of Me Vol.25 No.-
The bone marrow biopsy is an integral of the staging process in patients with malignant lymphomas. Marrow involvement indicates stage Ⅳ disease, but there are always some cases in which clear distinction is not possible based on morphology alone. Additional difficulties are caused by morphologic discordance between the bone marrow and the primary lymphoma. Immunohistochemical stain, mRNA in situ hybridization and polymerase chain reaction were performed to find out the minimal lesion and the clonality in formalin fixed paraffin embedded tissues of 39 primary lymphomas and corresponding bone marrow biopsy specimens. As a result, nine morphologically negative bone marrows of 18 lymphomas were positive by PCR (Group Ⅰ). Among the 6 lymphomas with morphologically suspicious bone marrow involvement (Group Ⅱ), one was confirmed to be positive for marrow involvement by both mRNA ISH and PCR and other four cases by PCR alone. The positive bone marrows of Group Ⅰ and Ⅱ revealed gene rearrangement at the same time as the primary lesion, suggesting the same clonality. Thirteen of 15 lymphomas with morphologically positive bone marrow(Group Ⅲ) had the same clonality in the primary lymphomas and the bone marrow lesion. Three cases among the Group Ⅲ with morphologic discordance also revealed the same clonality by PCR. This study shows that combination of mRNA ISH and PCR in addition to immunohistochemical stain improve the diagnostic sensitivity in the detection of bone marrow involvement and identification of clonality, and among the three methods used, PCR is the most sensitive in detecting minimal lesion.
Kawasaki Disease and Coxiella Burnetii
Lee, Won Young,Kim, Min Hee,Kim, Kyo Sun,Lee, Young Hyuk 건국대학교 의과학연구소 1992 건국의과학학술지 Vol.2 No.-
Kawasaki disease is an acute vasculitis characterized by mucosal inflammation, rash, cervical adenopathy, indurative edema of the hands and feet, and late desquamation of the fingertips. The cause of this systemic vasculitis is unknown. Thus the diagnosis is based solely on clinical criteria. We experienced two cases of Kawasaki disease. One patient had a typical case of Kawasaki disease combined with coronary aneurysm and hydrops of gallbladder. The other patient had an atypical case of Kawasaki disease, which was complicated by subdural hemorrhage. Both were associated with Coxiella burnetii infection.
Technique for Orthotopic Liver Transplantation in Cynomolgus Monkeys (Macaca Fascicularis)
( Kyo Won Lee ),( Jongwook Oh ),( Chan Woo Cho ),( Seunghwan Lee ),( Hyojun Park ),( Gyu-seong Choi ),( Jae Berm Park ),( Sung Joo Kim ),( Ji Soo Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Recent studies investigating new strategies to modulate the immune system have utilized animal models of liver transplantation (LT). However, the anhepatic phase (AHP) remains a crucial problem in LT. The aim of the present study is to introduce a technique for successful orthotopic liver transplantation in cynomolgus monkeys using an early-reperfusion strategy. Methods: Orthotopic allo-LT was performed with seven donor/recipient pairs of cynomolgus monkeys. Results: In two recipients, liver allografts were perfused after supra- hepatic inferior vena cava (SHIVC), portal vein (PV), and infra- hepatic inferior vena cava (IHIVC) anastomosis. To reduce the time of AHP in five recipients, liver allografts ware perfused after SHIVC and PV anastomosis while the IHIVC was not anastomosed.(Figure 1, 2) In the latter strategy, the AHP was reduced from 46 minutes to 31 minutes and a 24-hr survival rate of 80% was achieved. Conclusions: Our results indicate that an early-reperfusion strategy can be successfully used to establish a LT model in cynomolgus monkeys with a consistently high rate of animal survival.
WON-SANG KIM,KYO-BEUM LEE,BYOUNG-CHANG JEONG,SEUNG-HO SONG 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
The original direct power control (DPC) is known to give a fast response under transient conditions. However, active power, reactive power and current pulsations occur in steady-state operation. A family of variable structure controllers for the doubly fed induction generator (DFIG)-based wind turbine system is presented, using the principles of an active and reactive power controller known as modified DPC, and where variable structure control (VSC) and space-vector modulation (SVM) are combined to ensure high-performance operation. VSC scheme is designed following the modified DPC philosophy, which provides robust, fast, accurate active and reactive power controls without the problem of high chattering. Simulation results demonstrate that the proposed method preserves the effectiveness and robustness during variations of active and reactive power, rotor speed and converter DC-link voltage.
Microstructure of rapidly quenched YAG-based glass–ceramics prepared by aerodynamic levitation
Lee, Chi-Hoon,Jung, Sang-Kyo,Yoda, Shinichi,Cho, Won-Seung Elsevier 2015 CERAMICS INTERNATIONAL Vol.41 No.10
<P><B>Abstract</B></P> <P>Almost-spherical yttrium aluminum garnet (Y<SUB>3</SUB>Al<SUB>5</SUB>O<SUB>12</SUB>, YAG) was synthesized using an aerodynamic levitator. The formation of crystalline or glass–ceramic depended on the initial mass of the molten droplet. The YAG was devitrified due to partial crystallization, even after rapid quenching, indicating a high tendency for crystallization. The darker spheroid phase nucleated from the Y<SUB>2</SUB>O<SUB>3</SUB>–Al<SUB>2</SUB>O<SUB>3</SUB> melt because of a polyamorphic liquid–liquid phase transition. The optical transparency of YAG increased with increasing Eu<SUP>3+</SUP> content because of the reduced number of micro-sized crystals, which act as a scattering center to visible light. The photoluminescence intensity of the YAG:Eu glass–ceramic was attributed mainly to an electric dipole <SUP>5</SUP>D<SUB>0</SUB>→<SUP>7</SUP>F<SUB>2</SUB> transition because the Eu<SUP>3+</SUP> in the YAG glass–ceramic is located at sites with low symmetry.</P>