The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

CASE REPORT : Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy

( Kwang Taek Kim ),( Hyun Joo Jang ),( Jae Eun Lee ),( Mi Kang Kim ),( Jun Jae Yoo ),( Gye Yeon Lee ),( Sea Hyub Kae ),( Jin Lee ) 대한장연구학회 2015 Intestinal Research Vol.13 No.3

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among populations surrounding the Mediterranean Sea. FMF is the most prevalent autoinflammatory disease; is characterized by recurrent, self-limited episodes of fever with serositis; and is caused by Mediterranean fever gene (MEFV) mutations on chromosome 16. We describe a case of adult-onset FMF with complete symptomatic remission during pregnancy, without the use of colchicine. A 25-year-old woman had presented with periodic fever, abdominal pain, and vomiting since she was 21. Her abdominal computed tomography scan showed intestinal nonrotation. She underwent exploratory laparotomy and appendectomy for her symptoms 1 year prior. She had a symptom-free pregnancy period, but abdominal pain and fever recurred after delivery. Mutation analysis of the MEFV gene revealed two point mutations (p.Leu110Pro and p.Glu148Gln). We report an adult female patient with FMF in Korea with complete symptomatic remission during pregnancy. (Intest Res 2015;13:287-290)

레미콘 회수수의 안정적 재활용을 위한 교반수조의 설비유형 효과

이문환,이세현,박영신,박재명 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.2

Using the sludge water in producing ready mixed concrete, which is generated as washing surplus concrete after completing manufacturing and transportation of concrete is the best method in meeting the issue of cost of production and environment. However, in reality, using sludge water decreases Quality, and solid ingredients adhere to the transportation line of sludge water and the basin of sludge water, agitated to prevent precipitation of sludge, which incurs tremendous amount of repair expenses. In order to resolve the problems above, we have studied stable methods of supplying sludge water and experimentally reviewed the types of facilities. The result showed that a facility that added stabilizing agents which retarded hydration of unhydrated cement in sludge water for certain periods (2-3 days) and simultaneously agitated and moved by air diffusion and vertical flat blade impeller was most effective in stabilizing concentration of solid and preventing precipitation of solid in the bottom of basin. In addition, the performance of agitation and prevention of adherence of reaction basin of sludge water depended on selective efficiency of sand grain, and it has been studied that buffering inconsistent band of circulation of sludge water by operating the ring blower for air diffusion to the maximum was advantageous to preventing managing concentration and prevention of adherence.

주의력 결핍 과잉행동장애 아동의 평가를 위한 정지신호 과제의 적용

시현석,이종범,박형배,사공정규,송창진,배진우 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적 및 방법 : ADHD환아에 있어 뇌의 전두엽의 기능인 실행기능 중 특히 억제기능을 가장 잘 측정하는 것으로 알려진 정지신호과제를 사용하여 실제로 정지신호를 ADHD환아에게 적용하였을 때 정상 아동과 비교하였을 때 ADHD의 전두엽의 실행기능 중 억제 기능의 이상을 실질적으로 반영하는 검사인지, 증상의 정도와 수행결과는 어떤 연관성을 보이는지, 현재 가장 널리 사용되고 있는 연속수행 검사와는 어떤 차이를 보이는지, 과잉행동의 유무와 수행의 연관성은 어떠한지 그리고 부가적으로 정지신호과제의 ADHD진단에 있어서의 판별력은 어느 정도인지를 알아보기 위해 본 연구를 시행하였다. 전두엽의 기능을 반영하는지와 임상에서의 유용성을 알아보기 위해 ADHD군 40명과 대조군 18명을 대상으로 연구하여 다음과 같은 결과를 얻었다. 결 과 : 대조군과 ADHD군의 비교에서는 정지신호과제의 수행 성적은 상대적 종결속도의 Z점수(ZRFT)와 블록당 평균 지연시간(mean delay×block), 그리고 일차 반응시간(primary-RT)에 있어서 유의한 차이가 있는 것으로 나타났다(p<0.05), ADHD군과 대조군의 연속수행검사(CPT)의 수행에 있어 유의한 차이가 나는 변인은 없었다. 또한 두 검사간의 상관성에 있어서는 정지신호반응시간(SSRT)와 CPT의 정반응시간이 그리고 primary-RT와 일차반응시간의 표준 편차(primary-SD)가 CPT의 민감도와 정반응시간과 상관성이 있는 것으로 나타났다(p<0.05). 정지신호과제 수행과 한국형 주의력결핍 장애 평가 척도 - 가정판(ADDES-HV)과의 상관도에서는 유의한 상관성을 나타낸 것은 없었다. 나이와 지능에 따른 정지신호과제의 경향분석에서 유의하게 경향성을 나타낸 것은 지에 따른 차이에서는 primary-SD였으며 나이에 따른 차이에서는 SSRT였다(p<0.05). 여기에서 지능과 primary-SD와의 관계는 지능이 증가함에 따라 감소하다 어느 정도에서 더 이상 감소하지 않았으며, 나이와 정지신호반응시간과의 관계는 나이가 증가함에 따라 반응시간이 짧아지다가 어느 정도에서 더 이상 감소하지 않는 추세를 보였다. 정지신호과제의 판별력 검증에서 mean delay×block과 primary-RT가 가장 높은 판별력(각각 75%)을 나타냈으며 그 외 억제율(P-inhibit)은 63.89%, SSRT는 58%, ZRFT는 67%, primary-SD는 58%의 판별력을 보였다. ADDH 환아를 대상으로 과잉행동이 있는 군과 없는 군으로 나누어 수행의 정도를 비교하였다. 여기에서는 두 군 사이에 유의한 차이가 있는 변인은 없었다. 결 론 : 이러한 결과로 볼 때 정지신호과제가 국내에서 사용된다면 향후 임상에서의 ADHD의 선별검사로서 뿐만 아니라 연구에 있어서도 기여하는 바가 크다고 생각된다. Objectives and Methods : The purpose of this study was to examine availabilities of stop-signal task as a screening test for ADHD and as a research tool. Stop-signal task was applied to 40 ADHD patients and 18 normal children. Followings are the results of this study. Results : There were significant differences between ADHD group and control group in ZRFT, mean delay×block and primary-RT of stop-signal task performance(p<0.05). There was no significant difference in results of continuous performance test. SSRT of stop-signal task had significant correlation with hit reaction time of continuous performance test, and primary-RT and primary-SD with attentiveness and hit reaction time of continuous performance test. There was no significant correlation between scores of ADDES-HV and stop-signal task performance. In change of primary-SD according to intelligence, primary-SD decreased as intelligence increased but made plateau after IQ 110, and in change of SSRT according to age, SSRT decreased as intelligence increased but made plateau after 10 year-old. In discriminant ability, mean delay×block and primary-RT showed highest discriminant ability(each 75%). In addition P-inhibit showed 63.89%, SSRT showed 58%, ZRFT showed 67%, and primary-SD showed 58% in discriminant ability. There was no significant difference in stop-signal task performance between ADHD with hyperactivity and ADHD without hyperactivity. Conclusions : In this point of view, stop-signal task was proved to be useful research tool for attention deficit hyperactivity disorder as well as useful screening test tool.

出産進度에 영향을 주는 要因分析 : Longitudinal Approach

韓聖鉉,李時伯 家族計劃硏究院 1977 家族 計劃 論集 Vol.4 No.-

우리나라 사망구조의 지역별 차이에 관한 연구

한소현,이시백 서울大學校 保健大學院 2001 보건학논집 Vol.38 No.1

It is recognized that decreased mortality increasing the length of human life has been the major factor in acceleration of population increase. Therefore, death remains a subject of deep concern not only to the person but also government at all levels. The purpose of this present study is to measure the differences in death rates of region which persist the general reduction in mortality. The data for the present study of trend in differential mortality by region were derived from the official mortality statistic of Korea from 1980 to 1999. Mortality differentials were calculated for male and female by geographic region using age-adjusted death rates. It is apparent that there were considerable differences in age-adjusted death rates by region. Mortality was higher in Jeonam and Kyungbuk provinces for each sex than kyung-gi province and city area.

재생골재 생산방식의 차이에 따른 재생 굵은골재의 품질 특성에 관한 비교 연구

심종우,이문환,이세현,전현규 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The purpose of this study is intended for effective recycling of waste concrete. It analyzes the quality 0 the recycled coarse aggregate with production types. The conclusions of the study are as follows. 1. The recycled coarse aggregate which is produced through 5th Crushing Process (A-Type) shows the improvement in grading and particle shape, reduction in an absorption rate until 1.14% due to removal of attached the mortar and paste. Therefore, it satisfies the standards of KS F 2573(recycled aggregate for concrete) as the first grade. 2. The recycled coarse aggregate which is produced through 3rd Crushing Process(B-Type) is suited to the quality prOVlSlOns of the standards of KS F 2573, shows a 3.12% absorption rate that is second grade as recycled coarse aggregate. Based on the above results, it is possible to product first and second grade recycled coarse aggregates with production types. It is concluded that recycled coarse aggregate with production types can be used as aggregate within required conditions. And more researches are also needed to make recycled coarse aggregate better to use for concrete.

국내 생산 재생골재의 품질수준 평가

전명훈,이세현,이성복,이도헌 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

Recycling waste concrete is very important for environmental pollution prevention, overcome aggregates shortage and effective use of resource. The examples of using recycled aggregates such as ground backfill, road construction, concrete production. But, aggregate for structural concrete requires high degree of quality. We investigated the quality of domestic recycled aggregates in order to activate the use of recycled aggregates to seek the technologically, politically supplement factors to contribute to the effective use of recycled aggregates which has ever been a national problem, and which would solve the aggregates shortage.

싸이클론의 건식 공정으로 생산된 재생 잔골재를 사용한 콘크리트의 중성화 저항성 및 건조수축에 관한 실험적 연구

김병윤,이세현,서치호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The purpose of this study was to provide durability data of concrete using recycled fined aggregate which was produced through a dry production with cyclone for making it sure whether it can be put to practical use for concrete. In the experiment. recycled fine aggregate was substitute for natural fine aggregate the rate of 0, 25, 50, 75 and 100% each. The results of the study were as follows; 1. The depth of neutralization was become deeper according to the increase of substitutive ratio of recycled fine aggregate. 2. The performance of length alternation was fallen gradually according to the increase of substitutive ratio of recycled fine aggregate. But, it showed the similar durability with concrete using natural fine aggregate fewer than 25% substitution ratio. Based on the above results, it is concluded that the recycled fine aggregate through the wet production process can be used as fine aggregate on condition that the substitution ration is under 25%.

플라이애쉬와 제지애쉬를 혼합 사용한 모르타르의 특성에 관한 실험적 연구

송태협,이세현,서치호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The fly ash has been widely used in the latest to complement the physical performance and economical efficiency of the concrete which uses only a normal porland cement. The paper ash gained through the incineration of paper sludge is possible to be used as the material of concrete because it contains the properties similar to the previous fly ash in ingredients and physical characteristics. Therefore, this research has tested the physical characteristics by replacing 20 % of fly ash used with the paper ash to solve the problem which lowers the early strength caused when the fly ash was used. As a result, it showed that the fluidity becomes lower and the compression strength becomes increased by using paper ash. In addition, after mixing the paper ash with the fly ash, it showed that the time and heating amount of the 2nd peak of the minor heat of hydration affecting the revelation of strength was equivalent to the combination for normal portland cement, and also indicated that the compression strength for 3 days is superior to the combination of the fly ash. Therefore, if the paper ash having a regular fineness is used, it was effective in improving the early strength of concrete used the fly ash.