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Diary! ether: Synthesis and biological evaluation as antimitotic agents
AHN soon Kil,LEE Mi-sung,IN Jin-Kyung,YANG Jun geun,KWAK Jae-Hwan,LEE Heesoon,JUNG Jae-Kyung,BOOVANAHALLI Shanthaveerappa K .,LEE Kyeong,CHOI Nam Song,LEE sungsook,MOON Seung Kee,KIM Soo Jin 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2
Lee, Young-Keun,Chang, Hwa-Hyoung,Lee, Ho-Jin,Park, Heesoon,Lee, Kyung Hee,Joe, Min-Ho Published by Elsevier/North Holland on behalf of t 2006 FEMS microbiology letters Vol.257 No.2
<P>We isolated nickel-resistant bacterium from soil in order to identify a novel nickel resistance determinant. Using 16S rRNA gene sequencing, an isolate was identified as Enterobacter sp. Ni15. This species showed a medium-level (resistant to up to 10 mM) nickel resistance in nutrient-rich media. Enterobacter sp. Ni15 has a novel plasmid, pNi15, and an increased nickel resistance to Escherichia coli DH5alphain trans. To isolate the nickel resistance gene from pNi15, the plasmid was digested with XbaI and its fragments were cloned into pBluescriptIISK(+). The clones were transferred into E. coli DH5alpha. The nickel resistance of the clones was then assayed. From these results, a pNi15100 isolate containing a 5,328 bp XbaI fragment of pNi15 was identified and sequenced. The E. coli DH5alpha harboring the pNi15100 showed a resistance to up to 7 mM nickel. Using a subcloning analysis, we were able to identify the novel nickel resistance determinant: the nrp gene encoding the putative proteins NrpA and NrpB.</P>
Synthesis and In Vitro Cytotoxicity of 3-or 4-Dialkylaminomethyl-1-azaanthraquinones
Lee, Heesoon,Choi, Jae-Young,Lee, Seung-lI,Hong, Seoung-Soo,Cho, Jungsook,Kim, Young-Ho 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.
Synthesis and In vitro Evaluation of 4-Substituted-1-azaanthraquinones
Lee, HeeSoon,Hong, Seoung-=Soo,Choi, Jae-Young,Cho, JungSook,Kim, Young-Ho 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
Doxorubicin and daunomycin are the best known members of the anthracycline antibiotics and the most commonly used intercalaing agents in the treatment of cancer(Wakelin and Waring, 1990). Doxorubicin has a broad spectrum of activity, being particularly efficacious against solid tumors. However its clinical usefulness is limited by cardiotoxicity that develop after extended therapy, and the appearance of an acquired resistance (Priebe, 1995; Surato et al 1990). Synthetic analogues, mitoxantrone and ametantrone, resulted from efforts to produce anthracycline analogues that lack cardiac toxicity. Mitoxantrone in particular currently plays an important role in the clinical management of hematological malignancies such as chronic myelogenous leukemia, acute nonlymphoblastic leukemia, and non-Hodgkin's lymphoma, as well as in combination therapy of refractory overian and breast cancers (Wakelin and Waring, 1990). Although mitoxantrone is endowed with an improved tolerability profile compared with doxorubicin and other anthracylines, this drug is not devoid of significant toxic side effects especially those associated with myelosupporession(Gandolf et al., 1995). A number of studies have identified mitoxantrone as an intercalating agent, all indications being that its biological activity is attributable to its DNA-binging properties. DNA intercalation and interference with the DNA-topoisomerase Ⅱ activity resulting in protein associated DNA strand breaks have been proposed as critical events that lead to mitoxantrone-induced cell death(Wakelin and Waring, 1990). The search for new analogues side effects of the anthracycline analogues is of extreme interest and numerous analogues have been reported(Priebe, 1995).
SYNTHESIS AND IN VITRO EVALUATION OF 3-SUBSTITUTED-1-AZAANTHRAQUINONES
Lee, Heesoon,Hong, Seoung-Soo,Kim, Young-Ho 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-
In the course of developing novel antitumor agents, we synthesized 3-substituted-1-azaanthraquinones, incorporating the alkylating or latent alkylating substituents as potential antitum or agents. The most active comound 4 exhibited cytotoxic activity comparable to that of doxorubicin. The compounds 38 retained much of their activity against the doxorubicin-resistant cell line(MCF7/R). Copyright ⓒ 1996 Elsevier Science Ltd
Design and Synthesis of Isoindoloquinoline Derivatives as Potential Antitumor Agents
Lee, Heesoon,Jeong, Ilyeong,Yang, Sung-Il The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.4
A series of isoindoloquinoline derivatives was synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HCT15, SK-OV-3, MDA-MB-468 and T-47D).
박희순(Heesoon Park),이채영(Chae-Young Lee),이동근(Dong-geun Lee),강효중(Hyo-jung Kang),신현만(Hyunman Shin) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11
농경지에 유기질 비료를 시비하면 토양의 양분 함량을 높이고 미생물 생장을 촉진하여 농업 생산성을 높일 수 있다. 본 연구에서는 대추 시설 재배에서 2017년부터 2020년까지 유기질 비료 중 유박을 기비 처리하여 대추의 과실 성분에 미치는 영향을 화학비료 처리와 비교하여 평가하였다. 충북 보은군의 비가림하우스에 식재된 6년생 복조(Zizyphus jujuba var. inermis (Bunge) Rehder) 품종을 대상으로 매년 3월 토양검정 후 질소성분량 기준으로 유박과 화학비료를 1회 처리하였다. 비료 처리 2년 후인 2018년부터 연도별 대추 수량을 조사한 결과 유박을 처리하였을 때 주당 총 수량과, 상품수량, 횡경 28 mm 이상의 대과 수량이 많은 것으로 조사되었고 비상품과 중 열과 발생은 화학비료 처리에서 많았으며 위조과는 유박 처리에서 많은 것으로 나타났다. 비료 처리에 따른 과일 특성을 살펴본 결과, 대추 과일의 상품성에 큰 영향을 미치는 과일의 횡경과 과중, 당도가 유박 처리구에서 화학비료 처리구보다 더 우수한 것으로 나타났다. 또한 DPPH와 ABTS 라디컬 소거 활성과 비타민 C, 총플라보노이드의 함량이 유박이 처리된 토양에서 자란 대추 과실에서 더 높게 나타났다. 대추의 과일 수량에 토양 미생물 군집이 영향을 주었는지를 알아보기 위해 주 좌표 분석을 실시한 결과, 유박을 처리하였을 때 형성된 토양 세균 군집은 대추의 주당 총 수량과 상품수량, 대과(횡경 28 mm 이상) 수량, 상품수량지수 그리고 비상품과 중위조과 수량에 영향을 주는 것으로 나타났으며 화학비료 처리 토양의 세균 군집은 열과 수량에 영향을 주는 것으로 분석되었다. 이러한 결과로부터 대추과원의 지속적인 토양 양분 관리를 위해 유박의 활용이 가능할 것으로 판단되었다.