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( Sang Jin Lee ),( Na Rae Kim ),( In Sook Choi ) 경남대학교 신소재연구소 2012 신소재연구 Vol.24 No.-
In order to investigate the consolidating mechanism of the weathered ston monuments containing clay minerals, the consolidating effects were studied by applying 9 types of the ethylsilicates consolidants onto the shale containing clay minerals. XRD and SEM were used to find the influence of the clay minerals. The XRD results showed that the lattice spaces of the clay minerals was changed by infiltrating the consolidants. Through the investigation of the reaction mechanism between the stone samples containing clay minerals(smectites) and the consolidants, both the expansion and the shrinkage of the lattice space were found. On the contrary, in case the swelling inhibitor were applied to the stone samples containing the clay minerals, the changes of the lattice space were reduced.
( Sang Gyun Kim ),( Chan Mi Park ),( Na Rae Lee ),( Jiyoung Kim ),( Da Hyun Lyu ),( Seung-Hee Park ),( Il Ju Choi ),( Wan Sik Lee ),( Seun Ja Park ),( Jae Jun Kim ),( Ji Hyun Kim ),( Chul-Hyun Lim ),( 대한소화기학회 2018 Gut and Liver Vol.12 No.4
Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies. (Gut Liver 2018;12:402-410)
Lee, Sang Hae,Park, Jo Ryoung,Jeong, Mi-Yun,Kim, Hwan Myung,Li, Shaojun,Song, Jongwon,Ham, Sihyun,Jeon, Seung-Joon,Cho, Bong Rae WILEY-VCH Verlag 2006 CHEMPHYSCHEM -WEINHEIM- Vol.7 No.1
<P>A series of donor–acceptor substituted stilbene and diphenylacetylene derivatives and their octupolar analogues have been synthesized and the linear and nonlinear optical properties (β) studied by both experiments and theoretical calculation. The λ<SUB>max</SUB> of the dipoles increases with the conjugation length and is always larger when the C&n.dbond;C bond is used, instead of the C≡C bond, as the conjugation bridge. Although the λ<SUB>max</SUB> values of the octupoles show no clear trend, they are much larger than those of the dipoles. The β(0) values of the dipoles increase with conjugation length and as the conjugation bridge is changed from the C≡C to C&n.dbond;C bond. This increase is accompanied by an increase in either λ<SUB>max</SUB> or the oscillator strength. Similarly, the β(0) values of the octupoles increase with the conjugation length and with a change in the donor in the order: NEt<SUB>2</SUB><N(i-amyl)Ph<NPh<SUB>2</SUB>. Moreover, β<SUB>yyy</SUB>/β<SUB>zzz</SUB> ratios are in the range of 1.6–3.9 and decrease with the conjugation length. β values calculated by the finite-field and sum-over-states methods are in good agreement with the experimental data. Also, there is a parallel relationship between the calculated β values and bond length alternation (BLA). From these results, the origin of the larger β values for octupoles than for dipoles is assessed.</P> <B>Graphic Abstract</B> <P>Nonlinear optical chromophores: 1,3,5-Tricyano-2,4,6-tris(styryl)benzene derivatives and their triple-bond analogues (see figure) have been synthesized and shown to exhibit a large first hyperpolarizability, which is in the range: β(0)=252×10<SUP>−30</SUP> to 394×10<SUP>−30</SUP> esu. These β values are among the largest found in octupolar molecules and are significantly larger than those of the corresponding dipolar molecules. <img src='wiley_img/14394235-2006-7-1-CPHC200500274-content.gif' alt='wiley_img/14394235-2006-7-1-CPHC200500274-content'> </P>
( Sang Gyun Kim ),( Seon Mi Ji ),( Na Rae Lee ),( Seung-Hee Park ),( Ji Hye You ),( Il Ju Choi ),( Wan Sik Lee ),( Seun Ja Park ),( Jun Haeng Lee ),( Sang-Yong Seol ),( Ji Hyun Kim ),( Chul-Hyun Lim ) 대한소화기학회 2017 Gut and Liver Vol.11 No.1
Background/Aims: Endoscopic submucosal dissection (ESD) has been an established treatment for indicated early gastric cancer (EGC) without deterioration of quality of life (QOL) compared with surgical resection. The aim of this study was to evaluate long-term QOL in patients undergoing ESD for EGC. Methods: Patients scheduled to undergo curative ESD for EGC were prospectively enrolled from 12 institutions between May 2010 and December 2011. Assessments of QOL with Korean versions of the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire- core (QLQ-C30) and a gastric cancer-specific questionnaire (STO22) were performed at baseline and at 7 days, 3 months, and 6 months after ESD. Results: A total of 666 subjects were assessed for QLQ-C30 and QLQ-STO22. The mean QLQ-C30 score was 69.5 at baseline, 68.8 at 7 days, 73.1 at 3 months, and 73.2 at 6 months. The global health status on the EORTC QLQ-C30 was significantly improved after 3 and 6 months (p=0.0003 and p<0.0001, respectively). The QLQ-C30 and STO22 scores were not significantly different, or they only slightly deteriorated between before and immediately after ESD, but they were significantly improved after 3 and 6 months (p<0.05). Conclusions: QOL did not deteriorate immediately after ESD, and it improved more significantly at up to 6 months in patients who underwent curative ESD for EGC without significant complications. (Gut Liver 2017;11:87-92)
LEE, Sung-Rae,LEE, Ser-Hoon,HWANG, Sun-Young The Institute of Electronics, Information and Comm 2010 IEICE transactions on information and systems Vol.93 No.8
<P>This paper presents an efficient instruction scheduling algorithm which generates low-power codes for embedded system applications. Reordering and recoding are concurrently applied for low-power code generation in the proposed algorithm. By appropriate reordering of instruction sequences, the efficiency of instruction recoding is increased. The proposed algorithm constructs program codes on a basic-block basis by selecting a code sequence from among the schedules generated randomly and maintained by the system. By generating random schedules for each of the basic blocks constituting an application program, the proposed algorithm constructs a histogram graph for each of the instruction fields to estimate the figure-of-merits achievable by reordering instruction sequences. For further optimization, the system performs simulated annealing on the generated code. Experimental results for benchmark programs show that the codes generated by the proposed algorithm consume 37.2% less power on average when compared to the previous algorithm which performs list scheduling prior to instruction recoding.</P>
Lee, Choon-Taek,Park, Mi Young,Kim, Dal Rae,Choi, Eun Kyung,Yoo, Chul-Gyu,Kim, Young Whan,Han, Sung Koo,Shim, Young-Soo,Kim, Yeon-Soo D. A. Spandidos 2009 MOLECULAR MEDICINE REPORTS Vol.2 No.3
<P>Radiation is one of the main treatment modalities in lung cancer, but low sensitivity and acquired resistance of lung cancer cells to radiation frequently result in treatment failure. The activation of nuclear factor (NF)-κB is reportedly the main mechanism by which cancer cells exhibit resistance to external stresses, such as chemotherapy or radiation therapy. In this study, we blocked the activation of NF-κB by adenovirus-expressing IκBα-SR and investigated the effect this had on radiation sensitivity. Transduction with ad-IκBα effectively blocked the activation of NF-κB by radiation in all the cancer cell lines tested, except for NCI H460. Clonogenic assay after radiation demonstrated that ad-IκBα transduction enhanced the sensitivity to radiation of the lung cancer cell lines and HeLa cells, except for NCI H460. The radiosensitizing effect of IκBα was more potent in lung cancer cell lines with radioresistance (SKMESres) (sensitizer enhancement ratio 1:61). From these findings, NF-κB blockade by ad-IκBα enhanced the radiation sensitivity and also abolished the acquired radiation resistance of lung cancer cell lines. This study provides a therapeutic rationale for combining an NF-κB-blocking strategy with radiation to both increase sensitivity and overcome acquired resistance to radiation.</P>
Prediction of Cement Volume for Vertebroplasty Based on Imaging and Biomechanical Results
Lee, Sung-Jae,Tack, Gye-Rae,Lee, Seung-Yong,Jun, Bong-Jae,Lim, Do-Hyung,Shin, Jung-Woog,Kim, Jeong-Koo,Shin, Kyu-Chul The Korean Society of Mechanical Engineers 2001 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.15 No.7
Control of bone cement volume (PMMA) may be critical for preventing complications in vertebroplasty, the percutaneous injection of PMMA into vertebra. The purpose of this study was to predict the optimal volume of PMMA injection based on CT images. For this, correlation between PMMA volume and textural features of CT images was examined before and after surgery to evaluate the appropriate PMMA amount. The gray level run length analysis was used to determine the textural features of the trabecular bone. Extimation of PMMA volume was done using 3D visualization with semi-automatic segmentation on postoperative CT images. Then, finite element (FE) models were constructed based on the CT image data of patients and PMMA volume. Appropriate material properties for the trabecular bone were assigned by converting BMD to elastic modulus. Structural reinforcement due to the changes in PMMA volume and BMD was assessed in terms of axial displacement of the superior endplate. A strong correlation was found between the injected PMMA volume and the area of the intertrabecular space and that of trabecular bone calculated from the CT images (r=0.90 and -0.90, respectively). FE results suggested that vertebroplasty could effectively reinforce the osteoporotic vertebra regardless of BMD or PMMA volume. Effectiveness of additional PMMA injection tended to decrease. For patients with BMD well lower than 50mg/ml, injection of up to 30% volume of the vertebral body is recommended. However, less than 30% is recommended otherwise to avoid any complications from excessive PMMA because the strength has already reached the normal level.